Daily Archives: April 29, 2021
Study in England showed one dose of COVID-19 vaccine can cut household transmission by up to half – This protection is on top of the reduced risk of a vaccinated person developing symptomatic infection, which is around 60 to 65% after the first dose
29 Apr, 2021 | 08:44h | UTCNews release: One dose of COVID-19 vaccine can cut household transmission by up to half – Public Health England
Original study (preprint): Impact of vaccination on household transmission of SARS-COV-2 in England – Public Health England
Commentaries: Covid-19: One dose of vaccine cuts risk of passing on infection by as much as 50%, research shows – The BMJ AND Covid: One dose of vaccine halves transmission – study – BBC
Review: COVID-19-associated coagulopathy and antithrombotic agents – In non-critically ill hospitalized patients, therapeutic dose anticoagulation may improve clinical outcomes. In critically ill patients, this same treatment does not improve outcomes, and prophylactic dose anticoagulation is recommended
29 Apr, 2021 | 08:46h | UTCRelated: Full-dose Heparin best for moderate COVID-19 regardless of D-dimer — Data released from ACTIV-4a, ATTACC, and REMAP-CAP trials AND RCT: Intermediate-dose enoxaparin (1 mg/kg/d) not better than standard-dose prophylactic anticoagulation in patients with Covid-19 admitted to the intensive care unit
Commentary on Twitter
???State of the Art Review Article @TheLancetHaem by @MiddeldorpS
COVID-19-associated coagulopathy
Excellent explanation for the pathophysiology and great summary for the major RCTs and clinical guidelines https://t.co/NxP06KP2Hm pic.twitter.com/qHzyDsUZpt— Antibiotic Steward??Bassam Ghanem (@ABsteward) April 28, 2021
India’s surge leads to further global COVID rise as role of variants probed
29 Apr, 2021 | 08:41h | UTCIndia’s surge leads to further global COVID rise as role of variants probed – CIDRAP
See also: India Blames a Virus Variant as Its Covid-19 Crisis Deepens – The New York Times (free registration required) AND Why the COVID-19 Variants Spreading in India Are a Global Concern – TIME
Commentary on Twitter (thread – click for more)
Variant? “The current ?? wave of #COVID19 has a different clinical behavior. It’s affecting young adults. It’s affecting families. It’s a new thing altogether. Two-month-old babies are getting infected.” Also many reports of reinfections/breakthroughs.?https://t.co/qve23lduGb pic.twitter.com/FFIBaFsh0J
— Eric Feigl-Ding (@DrEricDing) April 28, 2021
Brazilian regulatory authorities decide not to approve the Gamaleya vaccine
29 Apr, 2021 | 08:38h | UTCBrazil Rejects the Gamaleya Vaccine – Science Translational Medicine
See also: Russia’s Sputnik V developers reject Brazil’s criticisms – Reuters
CDC Study: Pfizer-BioNTech and Moderna vaccines reduce Covid-19 hospitalization risk by 64% after the first dose and 94% after the second dose among adults aged ≥65 years
29 Apr, 2021 | 08:42h | UTCCommentaries: Pfizer/Moderna Vaccine Protection: 64% at First Dose, 94% at Second – HealthDay AND Pfizer and Moderna vaccines reduce Covid-19 hospitalization risk by 94% among older adults, CDC study says – CNN
Commentary on Twitter
New @CDCMMWR has good news: mRNA COVID-19 vaccines (Pfizer-BioNTech, Moderna) reduced the risk of #COVID19-related hospitalization by 94% among fully vaccinated people 65+. CDC recommends getting a COVID-19 vaccine to prevent severe COVID-19 illness: https://t.co/W4SFuV6wQp. pic.twitter.com/Jf4ph2rl4s
— CDC (@CDCgov) April 28, 2021
Ethics Commission Position Statement: Admission criteria and management of critical care patients in a pandemic context – “Age cannot be used as the sole criterion for admission nor denial of access to ICU settings”
29 Apr, 2021 | 08:36h | UTC
ACP Guideline: Appropriate Use of High-Flow Nasal Oxygen in Hospitalized Patients – “use high-flow nasal oxygen rather than noninvasive ventilation in hospitalized adults for the management of acute hypoxemic respiratory failure”
29 Apr, 2021 | 08:34h | UTC
China May Become World’s Biggest Vaccine Supplier As India Defaults On Global Deliveries
29 Apr, 2021 | 08:39h | UTC
British Society of Gastroenterology guidelines on the management of irritable bowel syndrome
29 Apr, 2021 | 08:31h | UTCBritish Society of Gastroenterology guidelines on the management of irritable bowel syndrome – Gut
Commentary on Twitter (thread – click for more)
Here are the new @BritSocGastro guidelines for #IBS in @Gut_BMJ! I'll summarize in ? ⬇️⬇️⬇️!
???????#GITwitter #GI #gut #braingut #motility #DGBI #FGID #microbiome #probiotics #MedTwitter #MedEd https://t.co/zbXoPbKgHO
— John Damianos, M.D. (@john_damianosMD) April 26, 2021
AHA Scientific Statement: Close monitoring for heart risk needed if breast, prostate cancer treatment includes hormonal therapies
29 Apr, 2021 | 08:33h | UTCNews release: Close monitoring for heart risk needed if breast, prostate cancer treatment includes hormones – American Heart Association
Top Things to Know: Impact of Hormonal Therapies for Treatment of Hormone-Dependent Cancers (Breast and Prostate) on the Cardiovascular System – American Heart Association
Commentaries: Hormonal Therapy for Breast and Prostate Cancer: Lessons and Opportunities – American Heart Association AND Hormonal Based Therapies in the Treatment of Breast and Prostate Cancer – balancing the risks! – American Heart Association AND Hormone Cancer Therapies Increase CV Risk: AHA Scientific Statement – TCTMD AND Closely Monitor Heart Health in Cancer Patients Who Get Hormonal Therapies: AHA – HealthDay
M-A: Extended thromboprophylaxis after hospital discharge for medically ill patients with cancer – Extended thromboprophylaxis is not associated with a reduced rate of venous thromboembolic events and is associated with increased risk of hemorrhage
29 Apr, 2021 | 08:28h | UTC
Review: Non-alcoholic fatty liver disease
29 Apr, 2021 | 08:30h | UTCNon-alcoholic fatty liver disease – The Lancet (free for a limited period)
M-A: Administration of vasopressor medications through a peripheral intravenous catheter is associated with low risk of adverse events
29 Apr, 2021 | 08:19h | UTCRelated Meta-Analysis: Complication of vasopressor infusion through peripheral venous catheter (study and commentary on Twitter)
Pre-post study: A hospital quality improvement intervention significantly reduced the rates of cesarean delivery for nulliparous, term, singleton, vertex births
29 Apr, 2021 | 08:21h | UTCHospital Quality Improvement Interventions, Statewide Policy Initiatives, and Rates of Cesarean Delivery for Nulliparous, Term, Singleton, Vertex Births in California – JAMA (free for a limited period)
Editorial: Initiatives to Reduce Cesarean Delivery Rates for Low-risk First Births – JAMA
Commentary on Twitter (thread – click for more)
"Rates of cesarean delivery for NTSV births in California decreased [from 26% to 22.8%] in the setting of a coordinated hospital-level collaborative and statewide initiatives designed to support vaginal birth.
"The rest of the US had no change."https://t.co/jwKkQZ4nix @cmqcc
— Ben Harder #BlackLivesMatter (@benharder) April 27, 2021
Podcast: Congenital Heart Disease for the General Pediatrician
29 Apr, 2021 | 08:18h | UTC#24: Congenital Heart Disease for the General Pediatrician – The Cribsiders