Daily Archives: April 1, 2021
Therapeutics and COVID-19 | WHO guideline update advises Ivermectin should only be used to treat COVID-19 within clinical trials
1 Apr, 2021 | 04:02h | UTCSummary and Infographic: Drug treatments for covid-19: living systematic review and network meta-analysis – The BMJ
Original guideline: Therapeutics and COVID-19: living guideline – World Health Organization
News release: WHO advises that ivermectin only be used to treat COVID-19 within clinical trials – World Health Organization
Commentary: WHO joins Europe, Merck in recommending against ivermectin for COVID-19 – Reuters
Commentary on Twitter
https://twitter.com/ThomasAgoritsas/status/1377372928451301384
ERAS Guidelines for Perioperative Care for Emergency Laparotomy: Part 1—Preoperative: Diagnosis, Rapid Assessment and Optimization
1 Apr, 2021 | 03:35h | UTC
Consensus Document: Management of superficial and deep surgical site infection
1 Apr, 2021 | 03:33h | UTCRelated Guidelines: Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery AND Global guidelines on the prevention of surgical site infection – World Health Organization AND Surgical site infections: prevention and treatment – National Institute for Health and Care Excellence AND APSIC guidelines for the prevention of surgical site infections – Antimicrobial Resistance & Infection Control
M-A: Vitamin D supplementation to prevent acute respiratory infections
1 Apr, 2021 | 03:30h | UTCCommentaries: Vitamin D to prevent acute respiratory infections – The Lancet Diabetes & Endocrinology AND
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
1 Apr, 2021 | 03:32h | UTC
Commentaries on Twitter
https://twitter.com/Dr_WuJ/status/1376715405553590275
Salt substitution (70% sodium chloride/30% potassium chloride blend) is an effective, low-cost intervention for BP controlhttps://t.co/EemPEY9T2k pic.twitter.com/xVITnGLEip
— K Pavithran (@drkpavithran) March 31, 2021
Podcast: Diagnosis and management of diabetic ketoacidosis in children
1 Apr, 2021 | 03:24h | UTC#22: DKA: Mind the Gap! – The Cribsiders Pediatric Medicine
Commentary on Twitter
🚨EPISODE 22: DKA, Mind the Gap!🚨
We welcome back pediatric endocrinologist Dr Hussein Abdullatif (@hussein45169069) to discuss all things Diabetic Ketoacidosis!#MedTwitter #tweetiatrician https://t.co/UQxhOsFGFc
— The Cribsiders – Pediatric Podcast (@TheCribsiders) March 31, 2021
RCT: Second-line FOLFOX chemotherapy vs. active symptom control for advanced biliary tract cancer
1 Apr, 2021 | 03:21h | UTCCommentary: Treating patients with advanced biliary tract cancers: Changing tactics – Cancer Research UK
Systematic review: Circumcision devices vs. standard surgical techniques in adolescent and adult male circumcisions
1 Apr, 2021 | 03:23h | UTC
Cohort study: Association of spontaneous abortion with all cause and cause specific premature mortality
1 Apr, 2021 | 03:27h | UTCCommentaries: Miscarriage linked to increased risk of early death – The BMJ AND Miscarriage Linked to Higher Risk for Premature Mortality – HealthDay
Commentary on Twitter
Study suggests spontaneous abortion is associated with a greater risk of premature death, particularly from cardiovascular disease. Spontaneous abortion could be an early marker of future health risk in women, including premature death, say the authorshttps://t.co/mA7IrF0J00
— The BMJ (@bmj_latest) March 28, 2021
RCT: Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer
1 Apr, 2021 | 03:19h | UTCAdjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: The effect of external ventricular drain tunneling length on CSF infection rate in pediatric patients
1 Apr, 2021 | 03:16h | UTC
Commentary on Twitter
In this randomized, double-blind, controlled trial in @TheJNS:
External ventricular drain tunnel lengths of 5 cm and longer did not show a difference in the CSF infection rate in pediatric patients. https://t.co/RohLQpttCZ
— Saleh Almenawer, MD (@SalehAlmenawer) March 25, 2021
Editorial | Vaccine certificates: does the end justify the means?
1 Apr, 2021 | 03:41h | UTCVaccine certificates: does the end justify the means? – The Lancet Microbe
Related: Covid-19 vaccine passports will harm sustainable development – The BMJ Opinion AND Covid-19 vaccine passports and vaccine hesitancy: freedom or control? – The BMJ Opinion AND “Vaccine Passport” Certification — Policy and Ethical Considerations – New England Journal of Medicine AND Interim position paper: considerations regarding proof of COVID-19 vaccination for international travellers – World Health Organization
WHO: Sinopharm, Sinovac COVID-19 vaccine data show efficacy
1 Apr, 2021 | 03:58h | UTCSinopharm, Sinovac COVID-19 vaccine data show efficacy: WHO – Reuters
Commentary on Twitter
https://twitter.com/hildabast/status/1377377034180038659
AstraZeneca COVID vaccine 70% effective vs. B117 variant
1 Apr, 2021 | 03:55h | UTCAstraZeneca COVID vaccine 70% effective vs B117 variant – CIDRAP
Commentary on Twitter (thread – Click for more)
ASYMPTOMATIC & SYMPTOMATIC Efficacy of Oxford-AstraZeneca #COVID19 vaccine versus #B117 & non-B117 variants via 200k swabs in ~8500:🧵
Symptomatic #B117➡️ 70%
Asymptomatic #B117➡️ 29%
Other variants symptomatic➡️ 81.5%
Other variants asymptomatic➡️ 70%https://t.co/qSWYlHKP0g pic.twitter.com/gS7P9MCpyz
— Eric Feigl-Ding (@DrEricDing) March 31, 2021
[Press release – not published yet] Pfizer-BioNTech vaccine 100% effective against Covid-19 in adolescents
1 Apr, 2021 | 03:52h | UTCPress release: Pfizer-BioNTech Announce Positive Topline Results Of Pivotal Covid-19 Vaccine Study In Adolescents
Commentaries: The Pfizer-BioNTech Vaccine Is Said to Be Powerfully Protective in Adolescents – The New York Times AND Covid: Children ‘well protected by Pfizer vaccine’ – BBC AND Pfizer Says COVID-19 Vaccine Shows ‘100% Efficacy’ In Adolescents – NPR AND Pfizer says its COVID-19 vaccine protects younger teens – Associated Press AND Pfizer and BioNTech say vaccine prevents Covid-19 in adolescents – STAT
Commentaries on Twitter
https://twitter.com/hildabast/status/1377376427239075840
This is really terrific
In trial of 2260 adolescents 12-15 year of age, Pfizer vaccine highly effective at preventing infections
18 infections in placebo group
0 infections in vaccine group
Robust antibody response
No serious side-effects
Looking forward to @US_FDA review https://t.co/VymGXOVb5E
— Ashish K. Jha, MD, MPH (@ashishkjha) March 31, 2021
Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study
1 Apr, 2021 | 03:43h | UTC
Commentary on Twitter
Follow-up of nearly 48,000 hospitalized patients with covid-19 shows a high rate of readmission, death, and multi-organ disease (heart, diabetes, kidney, lung) compared with matched controls https://t.co/dzxVYdugz2 @bmj_latest pic.twitter.com/hWBn5w2XQf
— Eric Topol (@EricTopol) April 1, 2021
Bill Gates: 5 things you should know about variants
1 Apr, 2021 | 03:49h | UTC5 things you should know about variants – GatesNotes
Commentary on Twitter
Here are five things you should know if you want to understand how variants are (and aren’t) complicating the pandemic. https://t.co/rANiDcZynJ
— Bill Gates (@BillGates) March 31, 2021
Despite Chile’s Speedy Covid-19 Vaccination Drive, Cases Soar
1 Apr, 2021 | 03:46h | UTCDespite Chile’s Speedy Covid-19 Vaccination Drive, Cases Soar – The New York Times (free registration may be required)
Commentary on Twitter (thread – click for more)
Hospital ICUs overwhelmed despite fast vaccinations—Chile 🇨🇱 made a critical mistake—its government eased restrictions on travel, business and schools much too early, creating a false sense of confidence that pandemic was over. This always been my fear. 🧵https://t.co/6McpZjekxT pic.twitter.com/NbmKPiOpLI
— Eric Feigl-Ding (@DrEricDing) March 30, 2021
Opinion | “Vaccine Passport” Certification — Policy and Ethical Considerations
1 Apr, 2021 | 03:40h | UTCRelated: Covid-19 vaccine passports will harm sustainable development – The BMJ Opinion AND Covid-19 vaccine passports and vaccine hesitancy: freedom or control? – The BMJ Opinion AND Vaccine certificates: does the end justify the means? – The Lancet Microbe AND Interim position paper: considerations regarding proof of COVID-19 vaccination for international travellers – World Health Organization
Opinion | COVID-19: underpowered randomized trials, or no randomized trials?
1 Apr, 2021 | 03:42h | UTCCOVID-19: underpowered randomised trials, or no randomised trials? – Trials
Commentary on Twitter
One important reason why we don’t see any randomised trials of non-pharmaceutical interventions is that they need to have thousands of participants to be sufficiently “powered”, statistically. I think underpowered trials are better than no trials. https://t.co/UsYfPO12kX
— Atle Fretheim (@AtleFretheim) March 31, 2021