Daily Archives: March 26, 2021
Evolution of the randomized clinical trial in the era of precision oncology
26 Mar, 2021 | 08:35h | UTCEvolution of the Randomized Clinical Trial in the Era of Precision Oncology – JAMA Oncology
Commentary on Twitter
Food for thoughts: randomized clinical trials in the era of precision oncology
➡️PFS, not OS predominant endpoint
➡️Modest median survival gains
➡️Almost all industry funded
➡️Substantial increase in use of professional medical writers#radonchttps://t.co/k92MEs1eWR— Matthias Guckenberger (@Mat_Guc) March 25, 2021
ERC and ESICM Guidelines: Post-resuscitation Care
26 Mar, 2021 | 08:41h | UTC
Commentary on Twitter
Post #resuscitation @ERC_resus @ESICM guidelines #resus21
🫀diagnosis & reperfusion
🫀post CA syndrome
🫀hemodynamics
🫁oxygenation/ventilation
🧠general #ICU approach
🧠seizures control
🌡️TTM
🧠prognosis & outcome
💪#ICUrehab
🫁organ donation
🏥CA centershttps://t.co/BrPJtKw8vo pic.twitter.com/xS0FKFSK6F— Intensive Care Medicine (@yourICM) March 25, 2021
FDA approval standards for anticancer agents — lessons from two recent approvals in breast cancer
26 Mar, 2021 | 08:30h | UTC
Commentary on Twitter
Our paper published today in @NatRevClinOncol discussing the dropping of bar for approval of cancer drugs. These two examples highlight why we all should seriously be concerned about this low bar. https://t.co/T27QI00dj2 pic.twitter.com/26Df3fJsoD
— Bishal Gyawali, MD, PhD, FASCO (@oncology_bg) March 25, 2021
RCT: Abrocitinib vs. Placebo or Dupilumab for Atopic Dermatitis
26 Mar, 2021 | 08:27h | UTCAbrocitinib versus Placebo or Dupilumab for Atopic Dermatitis – New England Journal of Medicine
RCT: Metoclopramide + diphenhydramine more efficacious than placebo for acute post-traumatic headache in the ED
26 Mar, 2021 | 08:24h | UTCRandomized Study of Metoclopramide Plus Diphenhydramine for Acute Posttraumatic Headache – Neurology (link to abstract – $ for full-text)
Commentary: Drug Combo Superior to Placebo for Posttraumatic Headache – HealthDay
M-A: Fracture risk is lower in patients anticoagulated with NOACs compared to patients treated with warfarin
26 Mar, 2021 | 08:26h | UTCCommentary: NOACs associated with a 16% lower risk of bone fractures than warfarin – Cardiovascular Business
Systematic review: Lens extraction for chronic angle‐closure glaucoma
26 Mar, 2021 | 08:22h | UTCLens extraction for chronic angle‐closure glaucoma – Cochrane Library
RCT: Fixed (40 mg twice daily) or variable (0.5 mg/kg twice daily) dosing of prophylactic enoxaparin after surgical procedures
26 Mar, 2021 | 08:23h | UTCOptimal Dosing of Prophylactic Enoxaparin after Surgical Procedures: Results of the Double-Blind, Randomized, Controlled FIxed or Variable Enoxaparin (FIVE) Trial – Plastic and Reconstructive Surgery (link to abstract – $ for full-text)
Pushing back against U.S. health officials, AstraZeneca says new analysis confirms efficacy of its Covid-19 vaccine
26 Mar, 2021 | 09:01h | UTCNews release: AZD1222 US Phase III primary analysis confirms safety and efficacy – AstraZeneca
See also: Latest results put Oxford–AstraZeneca COVID vaccine back on track – Nature AND AstraZeneca’s absurd and unprecedented dispute with regulators, explained – Vox AND Expert reaction to press release from AstraZeneca announcing primary data on safety and efficacy from the US trial of the Oxford-AstraZeneca COVID-19 vaccine – Science Media Centre AND AstraZeneca says COVID-19 vaccine 76% effective in new analysis, to seek U.S. approval – Reuters AND AstraZeneca’s new data showing Covid vaccine slightly less effective than suggested doesn’t worry experts – The Guardian AND Latest AstraZeneca Report Supports Effectiveness Of COVID Vaccine – NPR
Practice Pointer: Remote management of Covid-19 using home pulse oximetry and virtual ward support
26 Mar, 2021 | 09:05h | UTCRemote management of covid-19 using home pulse oximetry and virtual ward support – The BMJ
Related: Virtual clinics are reassuring but sometimes daunting – The BMJ
Commentary on Twitter
https://twitter.com/trishgreenhalgh/status/1375110854094520322
Experts: 3-foot rule in schools problematic in light of COVID variants
26 Mar, 2021 | 08:56h | UTCExperts: 3-foot rule in schools problematic in light of COVID variants – CIDRAP
Related: CDC Guidance for schools says students can now stay 3 feet apart, rather than 6
RCT: Similar number of days free of respiratory support with helmet noninvasive ventilation vs. high-flow nasal oxygen in patients with COVID-19 and moderate to severe hypoxemic respiratory failure
26 Mar, 2021 | 09:02h | UTCEffect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Respiratory Support During the COVID-19 Pandemic: Is It Time to Consider Using a Helmet?
Video: Helmet Noninvasive Ventilation of COVID-19 Patients
Variant-proof vaccines — invest now for the next pandemic
26 Mar, 2021 | 08:48h | UTCVariant-proof vaccines — invest now for the next pandemic – Nature
Another study shows increased transmissibility of SARS-CoV-2 lineage B.1.1.7 with a 50% to 100% higher reproduction number
26 Mar, 2021 | 08:57h | UTCAssessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England – Nature
Related: Study confirms higher transmissibility of SARS-CoV-2 lineage B.1.1.7 (study and commentary)
Commentary on Twitter
Just published @nature: Transmissibility of the B.1.1.7 (UK) variant https://t.co/dsMge8bB83 "A substantial transmission advantage with a 50 to 100% higher reproduction number"
Secondary attack rates were 30-40% higher than ancestral strain (non-VOC); no age gradient by modeling pic.twitter.com/870A3PojyF— Eric Topol (@EricTopol) March 25, 2021
The first and second waves of the COVID-19 pandemic in Africa: a cross-sectional study
26 Mar, 2021 | 08:44h | UTCThe first and second waves of the COVID-19 pandemic in Africa: a cross-sectional study – The Lancet
Commentary: Africa needs local solutions to face the COVID-19 pandemic – The Lancet
Commentary on Twitter (thread – click for more)
NEW—Continent-wide analysis suggests 30% increase in daily #COVID19 infections during rise of Africa's second wave compared with peak of the first. Authors urge improved data reporting, testing capacity, and renewed adherence to public health measures. https://t.co/bQq2F1Zrg0 pic.twitter.com/5TTSW7mkzF
— The Lancet (@TheLancet) March 25, 2021
Covid: The London bus trip that saved maybe a million lives (about the creation of the RECOVERY Trial)
26 Mar, 2021 | 08:53h | UTCCovid: The London bus trip that saved maybe a million lives – BBC
Related: Covid-19: The Inside Story of the RECOVERY Trial
Commentary on Twitter
Very cool story by @JamesTGallagher about a convo on a London bus that led to the creation of the RECOVERY trial, which has been a shining (& too rare) example of how to do critical research in a pandemic. Bravo @PeterHorby & @MartinLandray h/t @hildabast https://t.co/BRSJLSFXdc
— Helen Branswell 🇨🇦 (@HelenBranswell) March 25, 2021
Perspective | The emerging plasticity of SARS-CoV-2
26 Mar, 2021 | 08:47h | UTCThe emerging plasticity of SARS-CoV-2 – Science
Modeling study suggest patients should receive COVID-19 vaccine before surgery to reduce the risk of death
26 Mar, 2021 | 08:43h | UTCSee also: Infographic and Video
Commentary on Twitter
New from @CovidSurg–@GlobalSurg
🔸Vaccination significantly reduces death after elective surgery
🔸Fewer surgical patients need to be vaccinated than people in general population to save one life
▶️Prioritise elective surgery patients for vaccination
🆓https://t.co/iOUSixD6Cr pic.twitter.com/PTbOMoVPFl
— Dmitri Nepogodiev (@dnepo) March 25, 2021