Daily Archives: March 14, 2021
M-A: Effects of influenza vaccine on mortality and cardiovascular outcomes in patients with cardiovascular disease
14 Mar, 2021 | 20:25h | UTC
Revisiting the Ten Commandments of Emergency Medicine: A Resident’s Perspective
14 Mar, 2021 | 20:26h | UTCRevisiting the Ten Commandments of Emergency Medicine: A Resident’s Perspective – Annals of Emergency Medicine (free for a limited period)
Commentary: Ten Commandments of Emergency Medicine Revisited – Journal Feed
Phase 2 RCT: Donanemab in early Alzheimer’s Disease
14 Mar, 2021 | 20:21h | UTCDonanemab in Early Alzheimer’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Experimental Alzheimer’s drug could slow cognitive decline in patients, early results suggest – CNN AND Alzheimer’s study shows mixed results for Lilly’s donanemab on secondary outcomes – First World Pharma
Commentary on Twitter
In a phase 2 trial, patients with early Alzheimer’s disease who received donanemab, an antibody that targets amyloid deposits, showed a better composite score for cognition & ability to perform activities of daily living at 76 weeks than those who received placebo. #ADPD2021
— NEJM (@NEJM) March 13, 2021
Perspective | New lung cancer screening guideline comes with many caveats
14 Mar, 2021 | 20:23h | UTCNew lung cancer screening guideline comes with many caveats – Lown Institute
Original Guideline: USPSTF Statement: begin screening for lung cancer at age 50 years instead of 55 years for patients at risk (article and commentaries)
Clinical trial shows alcohol use disorder recovery can start without sobriety
14 Mar, 2021 | 20:17h | UTC
Commentary on Twitter (thread – click for more)
1/A new trial found a harm reduction treatment effective in reducing drinking in persons experiencing homelessness – from @TheLancetPsych — I was happy to write the editorial—. Press summary here: https://t.co/WoLVWqinm6
— Stefan Kertesz, MD (@StefanKertesz) March 12, 2021
Resurgence of Ebola Virus disease in Guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days
14 Mar, 2021 | 20:15h | UTCCommentaries: Bombshell analysis traces new Ebola outbreak to survivor of West Africa crisis – STAT AND New Ebola outbreak likely sparked by a person infected 5 years ago – Science AND Ebola survivors can pass on the virus: we’re trying to understand what role sex plays – The Conversation AND The latest Ebola outbreak may have started with someone infected years ago – Science News
Review: Transcatheter Aortic Valve Replacement in Bicuspid Aortic Valve Stenosis
14 Mar, 2021 | 20:11h | UTCTranscatheter Aortic Valve Replacement in Bicuspid Aortic Valve Stenosis – Circulation (free for a limited period)
Commentary on Twitter
Just published in Circulation, a review article in which we discuss the current role and future of TAVR in patients with a bicuspid aortic valvehttps://t.co/nIGlZNBe0D pic.twitter.com/DuavpFoU0p
— Philippe Pibarot (@PPibarot) March 8, 2021
RCT: Efficacy of a combination of conservative therapies vs. an education comparator on clinical outcomes in thumb base osteoarthritis
14 Mar, 2021 | 20:13h | UTCEfficacy of a Combination of Conservative Therapies vs an Education Comparator on Clinical Outcomes in Thumb Base Osteoarthritis: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Commentary: Mix of treatments could be way to restore hand function in thumb-base osteoarthritis – University of Sydney
Commentary on Twitter
In people with thumb base #osteoarthritis, a combination of conservative treatments provided small beneficial effects on hand function at 6 weeks, but not pain, compared to an education control. Effects on hand function and pain were greater at 12 weeks https://t.co/lxaIubgTKT
— JAMA Internal Medicine (@JAMAInternalMed) March 9, 2021
New COVID-19 risk calculator can predict severe disease or death among hospitalized patients with COVID-19
14 Mar, 2021 | 20:54h | UTCSee calculator: Severe COVID-19 Adaptive Risk Predictor (SCARP)
WHO adds Janssen vaccine to list of safe and effective emergency tools against COVID-19
14 Mar, 2021 | 20:57h | UTC
Commentary on Twitter (thread – click for more)
WHO has greenlighted the J&J vaccine, so it can be rolled out through COVAX & UN agencies! ? COVAX has an agreement for half a billion doses of the single-shot vaccine …1/2 https://t.co/3zaGoOC30i
— Hilda Bastian, PhD (@hildabast) March 13, 2021
[Preprint] RCT: Full-dose/therapeutic anticoagulation provides no benefit in critically ill patients with Covid-19
14 Mar, 2021 | 20:59h | UTCTherapeutic Anticoagulation in Critically Ill Patients with Covid-19-Preliminary Report – medRxiv
Related (results on moderately ill patients): [Not published yet] Full-dose Heparin best for moderate COVID-19 regardless of D-dimer — Data released from ACTIV-4a, ATTACC, and REMAP-CAP trials
Perspective | School reopening without robust COVID-19 mitigation risks accelerating the pandemic
14 Mar, 2021 | 20:51h | UTCSchool reopening without robust COVID-19 mitigation risks accelerating the pandemic – The Lancet
Covid vaccinations: No reason to stop using AstraZeneca jab, says WHO
14 Mar, 2021 | 20:46h | UTCCovid vaccinations: No reason to stop using AstraZeneca jab, says WHO
See also: Benefits Of AstraZeneca Vaccine Outweigh Risks, Say EMA and WHO Officials – Urging Jabs To Continue While Safety Data Around Blood Clots Is Reviewed – Health Policy Watch AND COVID-19 Vaccine AstraZeneca: PRAC investigating cases of thromboembolic events – vaccine’s benefits currently still outweigh risks – Update – European Medicines Agency AND Canada says AstraZeneca vaccine is safe after Norway and Denmark suspend use – Reuters
Urgent lessons from COVID 19: why the world needs a standing, coordinated system and sustainable financing for global research and development
14 Mar, 2021 | 20:47h | UTC
Commentary on Twitter
#COVID19 vaccines—developed, trialled, manufactured & authorised in several countries within a year. @VictorDzau et al. on lessons from the pandemic to inform an end-to-end global research & development preparedness & response ecosystem. Read https://t.co/G9PA5JBuaJ pic.twitter.com/EtFORBxvTl
— The Lancet (@TheLancet) March 12, 2021
Cohort study: Effectiveness of three vs. six feet of physical distancing for controlling spread of COVID-19 among primary and secondary students and staff
14 Mar, 2021 | 20:48h | UTC
Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes
14 Mar, 2021 | 20:43h | UTCEpidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes – Science
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity
14 Mar, 2021 | 20:44h | UTCMultiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity – Cell
Commentary: Vaccine-induced antibodies may be less effective against several new SARS-CoV-2 variants
Commentary on Twitter (thread – click for more)
Our paper describing the potential for mRNA vaccines to induce antibodies capable of neutralizing many of the circulating variants is now available online at Cell!https://t.co/c8B87Tg55S pic.twitter.com/eRM8ABJrQY
— Balazs Lab (@BalazsLab) March 12, 2021
Cohort study: Association of ablative radiation therapy with survival among patients with inoperable pancreatic cancer
14 Mar, 2021 | 20:09h | UTCAssociation of Ablative Radiation Therapy With Survival Among Patients With Inoperable Pancreatic Cancer – JAMA Oncology (free for a limited period)
Commentary on Twitter
Ablative RT to 98Gy biologically effective dose following multiagent induction therapy for locally advanced pancreatic cancer (LAPC) was safe & resulted in durable locoregional tumor control & favorable survival https://t.co/pLf52Tt6j0 #GICSM
— JAMA Oncology (@JAMAOnc) March 12, 2021
Guide to enhanced recovery for cancer patients undergoing breast surgery and reconstruction
14 Mar, 2021 | 20:01h | UTC
Study: Healthcare settings did not increase the risk for Covid-19 infection among health care workers in the US. Exposure outside the workplace was the strongest risk factor for SARSCoV2 seropositivity
14 Mar, 2021 | 20:41h | UTCCommentaries: Healthcare settings do not increase risk for Covid-19 infection spread – University of Maryland School of Medicine AND Did Healthcare Workers Catch Covid In Or Outside The Hospital? – MedicalResearch.com AND Community Covid-19 Risk Higher Than Workplace Risk for Health Care Personnel – Physician’s Weekly
Commentary on Twitter
Cross-sectional study finds #COVID19 exposure outside the workplace was the strongest risk factor for #SARSCoV2 seropositivity. No workplace factors were associated with seropositivity. @EmoryMedicine @UMMC @HopkinsMedicine @CDCgov https://t.co/DbdSxTEb8n
— JAMA Network Open (@JAMANetworkOpen) March 10, 2021
70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the phase 3 randomised MINDACT trial with an exploratory analysis by age
14 Mar, 2021 | 20:07h | UTC70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the phase 3 randomised MINDACT trial with an exploratory analysis by age – The Lancet Oncology (link to abstract – $ for full-text)
Meta-analysis of observational studies suggests better long-term oncologic outcomes with propofol-based total intravenous anesthesia compared to any volatile anesthesia
14 Mar, 2021 | 19:59h | UTC
Commentary on Twitter
? Patients who receive propofol-based TIVA for cancer surgery are associated with better overall survival than volatile anesthesia though there is no statistically significant difference in cancer-free survival between propofol-based TIVA https://t.co/lJHxmcqjtB pic.twitter.com/7gYmZYZRij
— Anesthesia&Analgesia (@IARS_Journals) March 3, 2021