Daily Archives: February 28, 2021
CDC Report: Reduction in severe COVID-19 following the implementation of a national vaccination program in Israel
28 Feb, 2021 | 21:54h | UTCCommentary: Israeli data suggest mass vaccinations led to drop in severe Covid cases, CDC study finds – CNBC
Commentary on Twitter
A new @CDCMMWR from Israel shows preliminary evidence of the effectiveness of vaccination in preventing severe cases of #COVID19. Vaccination among people who are eligible to receive a COVID-19 vaccine can potentially reduce severe disease from COVID-19. https://t.co/CaUAXRVaS4 pic.twitter.com/GyaulMONpZ
— CDC (@CDCgov) February 26, 2021
M-A: Treatment with convalescent plasma is not associated with better outcomes in patients with Covid-19
28 Feb, 2021 | 21:51h | UTCEditorial: Emerging Lessons From COVID-19 for the US Clinical Research Enterprise
Commentary on Twitter
Just out: Our meta-analysis in @JAMA_current
"Among patients with COVID-19, treatment with convalescent plasma compared with control was not associated with improved survival or other positive clinical outcomes"https://t.co/tRqpd9v67m
— Lars G. Hemkens (@LGHemkens) February 26, 2021
CDC Study: Suspected SARS-CoV-2 reinfections in a skilled nursing facility
28 Feb, 2021 | 21:55h | UTCCommentaries: Possible SARS-CoV-2 Reinfection Described at Skilled Nursing Facility – HealthDay AND Reinfections could be more likely among those with a mild first case of COVID-19: case study – CTV News
Commentary on Twitter (thread – Click for more)
📌CDC report: Asymptomatic or mildly symptomatic infections don't always produce sufficient immune response to prevent reinfection. Report of nursing facility found 5 people reinfected ~3 months after initial infection. All 5 had more severe symptoms 2nd time around, one death🧵 pic.twitter.com/m9ix9XJolA
— Dr. Ali Nouri (@AliNouriPhD) February 28, 2021
Short Review: SARS-CoV-2 Vaccines
28 Feb, 2021 | 21:52h | UTCAuthor interview: Coronavirus Vaccines—An Overview
Check out the Table ins this #SARSCoV2 Vaccine Overview – everything you wanted to know about upcoming vaccines – Oxford/AZ, Sputnik, Sinovac, more! https://t.co/TWbgfSKBIP
— JAMA (@JAMA_current) February 26, 2021
Studies: Single dose of vaccine acts as ‘booster’ in those with prior COVID-19 infection
28 Feb, 2021 | 21:49h | UTCStudy 1: Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals – The Lancet
Commentary on Twitter (thread – click for more)
New on 1-dose @Pfizer vaccine after prior covid
"We show that individuals with previous #SARSCoV2 infection generate strong humoral and cellular responses to one dose of BNT162b2 vaccine, with evidence of high titres of in-vitro live virus neutralisation"https://t.co/2G7TRu57OI pic.twitter.com/sIdB0VarqB— Eric Topol (@EricTopol) February 25, 2021
Identification of 3 clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19
28 Feb, 2021 | 21:45h | UTCInvited Commentary: Anticipating outcomes for patients with COVID-19 and identifying prognosis patterns
Commentary on Twitter
Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19 https://t.co/kLtzmF5ZWI 📣 These results might help to better classify patients for clinical management #COVID@SPAIN #COVID@HULP pic.twitter.com/ZVaMuUDfnL
— Alberto M. Borobia (@borobia_am) February 24, 2021
Spain to give just one vaccine dose to under 55-year olds who had COVID-19
28 Feb, 2021 | 21:47h | UTCSpain to give just one vaccine dose to under 55-year olds who had COVID-19 – Reuters
Related: Is One Vaccine Dose Enough After COVID-19 Infection? – NIH Director’s Blog AND France’s health authority recommends single vaccine shot for people who have had COVID-19
Long Read | 5 Pandemic Mistakes We Keep Repeating
28 Feb, 2021 | 21:43h | UTC5 Pandemic Mistakes We Keep Repeating – The Atlantic (a few articles per month are free)
Editorial | Twenty Lessons from 2020: With a Focus on the ICU Perspective
28 Feb, 2021 | 21:44h | UTCTwenty Lessons from 2020: With a Focus on the ICU Perspective – ICU Management & Practice
New report reviews methods for reducing waste, improving efficiency with expensive injectable medications
28 Feb, 2021 | 21:29h | UTCOriginal report: Medications in Single Dose Vials: Implications of Discarded Drugs (2021) – National Academies of Sciences, Engineering, and Medicine
Commentary on Twitter
"significant amounts of expensive injectable or infused drugs, distributed in single-dose vials, are discarded" but hard to quantify.
Medications in Single-Dose Vials and Implications of Discarded Injectable Drugs: A National Academies Report https://t.co/z3ebKGIcEg
— Suresh Nirody – snirody.eth (@snirody) February 26, 2021
2 Case Series and Guidance| Lymphadenopathy in COVID-19 Vaccine Recipients
28 Feb, 2021 | 21:42h | UTCCase series: Lymphadenopathy in COVID-19 Vaccine Recipients: Diagnostic Dilemma in Oncology Patients – Radiology
Related case series in women without cancer: Coronavirus Disease (COVID-19) Vaccination Associated Axillary Adenopathy: Imaging Findings and Follow-Up Recommendations in 23 Women – American Journal of Roentgenology
Related guidance 1: Multidisciplinary Recommendations Regarding Post-Vaccine Adenopathy and Radiologic Imaging: Radiology Scientific Expert Panel – Radiology
Related guidance 2: Mitigating the Impact of Coronavirus Disease (COVID-19) Vaccinations on Patients Undergoing Breast Imaging Examinations: A Pragmatic Approach – American Journal of Roentgenology AND Commentary: What to do when a mammogram shows swollen lymph nodes in women just vaccinated for COVID – Massachusetts General Hospital
Commentary: COVID-19 vaccine affects imaging results, researchers warn – AuntMinnie (free registration required)
Improving lung health in low-income and middle-income countries: from challenges to solutions
28 Feb, 2021 | 21:23h | UTCImproving lung health in low-income and middle-income countries: from challenges to solutions – The Lancet (free registration required)
Commentary on Twitter
LMICs bear a high burden of global morbidity & mortality from chronic respiratory diseases (CRDs). Read this review on improving lung health in LMICs—challenges in prevention, diagnosis, management, & pathways to universal health coverage: https://t.co/u8ToWFzwUl pic.twitter.com/gJQbO8B0Zk
— The Lancet (@TheLancet) February 24, 2021
Targeted spraying to prevent malaria in low-transmission setting halves cost of current practice
28 Feb, 2021 | 21:25h | UTCNews release: Targeted spraying to prevent malaria in low-transmission setting halves cost of current practice – Wits University
Commentary on Twitter
New paper from @davidjbath @CatKPitt and colleagues
@LSHTM_CHIL @LSHTM_malariaTargeting spraying for malaria control is safe, less costly, and cost-effective compared with standard spraying
With low incidence, these funds could be spent elsewhere🦟https://t.co/OCb9qhqBCX https://t.co/a0sD4uhymo
— Global Health Economics Centre (@LSHTM_GHECO) February 26, 2021
Turning houses into ‘lethal mosquito lures’ nearly halves incidence of malaria in children
28 Feb, 2021 | 21:26h | UTC
Commentary on Twitter (thread – click for more)
https://twitter.com/EDSternberg/status/1365083598538362882
RCT: Baclofen reduces agitation in patients with unhealthy alcohol use receiving mechanical ventilation, but results in a longer time receiving mechanical ventilation and more extended ICU stay
28 Feb, 2021 | 21:09h | UTCEditorial: Baclofen to Prevent Agitation Caused by Alcohol Withdrawal in the ICU
Video presentation: Effect of Baclofen on Agitation-Related Events Among Mechanically Ventilated Patients With Alcohol Use Disorder
Commentary on Twitter
In this phase 3 RCT, high-dose baclofen reduced agitation-related events vs placebo in patients with unhealthy alcohol use receiving mechanical ventilation; considering the modest effect & secondary endpoints & adverse events, further research is needed https://t.co/gHWEqZKfFv
— JAMA (@JAMA_current) February 23, 2021
RCT: Balanced opioid-free anesthesia with Dexmedetomidine resulted in a greater incidence of serious adverse events, especially hypoxemia and bradycardia
28 Feb, 2021 | 21:03h | UTC
RCT: similar outcomes in patients with heart failure with preserved ejection fraction randomized to high-intensity interval training vs. moderate continuous training vs. guideline-based physical activity advice
28 Feb, 2021 | 21:06h | UTCEffect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity Advice on Peak Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: Hold Off on HIIT for Patients with Heart Failure with Preserved EF – Physician’s Weekly
Commentary on Twitter
In this RCT, high-intensity interval training was no better at improving peak V̇O₂ at 3 months vs moderate continuous or guideline control training, in patients with #HFpEF https://t.co/CZzAcQESLg @TUMSportMedizin @jamacardiology @jamainternalmed #VisualAbstract
— JAMA Cardiology (@JAMACardio) February 22, 2021
RCT: An intensive blood pressure lowering strategy after successful endovascular therapy in acute ischemic stroke did not reduce radiographic intraparenchymal hemorrhage rates
28 Feb, 2021 | 20:59h | UTCSafety and efficacy of intensive blood pressure lowering after successful endovascular therapy in acute ischaemic stroke (BP-TARGET): a multicentre, open-label, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
Clinical Update: Enteric Fever
28 Feb, 2021 | 21:02h | UTCEnteric fever – The BMJ (free for a limited period)
Commentary on Twitter
Diagnosis of enteric fever is complicated as symptoms overlap with other causes of fever and early investigations are inconclusive. Here's what you need to know about its presentation, diagnosis, and treatment #BMJEducationhttps://t.co/1mvbNb7peS pic.twitter.com/Z7YxngHanl
— The BMJ (@bmj_latest) February 28, 2021
M-A: Risk predictors of progression to severe disease during the febrile phase of dengue
28 Feb, 2021 | 20:57h | UTC
Cognitive behavioral therapy for a variety of conditions: an overview of systematic reviews and panoramic meta-analysis
28 Feb, 2021 | 20:50h | UTC
Observational study suggests women have a lower range of ‘normal’ blood pressure than men
28 Feb, 2021 | 20:52h | UTCNews release: Women Have a Lower Range of ‘Normal’ Blood Pressure Than Men – Cedars-Sinai
Original study: Sex Differences in Blood Pressure Associations With Cardiovascular Outcomes – Circulation
Commentary: Women’s Risk for CVD Seen at Lower BP Thresholds Than Men – TCTMD
Commentary on Twitter
Sex differences in associations of systolic blood pressure with incident CVD: are sex-specific blood pressure goals needed? https://t.co/JibgGRh9uP #GoRedforWomen #AHAJournals @BP_Teemu pic.twitter.com/SWEWBjA2Nx
— Circulation (@CircAHA) February 17, 2021
RCT: Endoscopic surgery improves survival compared with intensity-modulated radiotherapy in resectable locally recurrent nasopharyngeal carcinoma
28 Feb, 2021 | 20:45h | UTC
Bioethics | Should clinical guidelines incorporate cost pathways for persons with financial hardship?
28 Feb, 2021 | 20:54h | UTC
Joint Statement: Hydroxychloroquine use with respect to retinal toxicity
28 Feb, 2021 | 20:41h | UTCCommentary: Societies Agree on Eye Safety for HCQ – MedPage Today (free registration required) AND ACR, medical societies reach consensus on hydroxychloroquine retinopathy – Healio (free registration required)
Commentary on Twitter
🆕 Joint statement on #Hydroxychloroquine use with respect to retinal toxicity 👀 by several #rheumatology and #opthtalmology societies. #ocular #toxicity relates to #HCQ dosage and duration of use and is seen in 4.3% to 13.8% of patients 🔎#Lupus #SLEhttps://t.co/ocFSCmgVsN
— Laurent ARNAUD (@Lupusreference) February 18, 2021