Daily Archives: February 11, 2021
RCT: Once-weekly, high-dose semaglutide is effective for improving overweight or obesity among non-diabetic adults
11 Feb, 2021 | 02:09h | UTCOnce-Weekly Semaglutide in Adults with Overweight or Obesity – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Semaglutide Plus Lifestyle Change Shown Effective for Obesity – NEJM Journal Watch
Commentary on Twitter
This double-blind study randomly assigned adults with obesity without diabetes to 68 weeks of once-weekly subcutaneous semaglutide or placebo, plus lifestyle intervention. Semaglutide therapy was associated with sustained, clinically relevant weight reduction.
— NEJM (@NEJM) February 10, 2021
Randomized, cross-over trial: Compared to Mediterranean diet, a Low-fat vegan diet is better at improving body weight, lipid concentrations, and insulin sensitivity
11 Feb, 2021 | 01:56h | UTC
Commentary on Twitter
36-week randomized cross-over trial:
?Low-fat plant-based diet reduced body weight, fat mass, and visceral fat, increased insulin sensitivity, and improved blood lipids, compared with a Mediterranean diet.https://t.co/ROJX9WYcix
— Danielle Belardo, MD (@DBelardoMD) February 6, 2021
ERS guidelines for the management of children and adolescents with bronchiectasis
11 Feb, 2021 | 02:05h | UTC
Near-equivalence in oncology: Generating evidence to support alternative cost-effective treatments
11 Feb, 2021 | 02:02h | UTC
Commentary on Twitter
Thoughtful piece with real implications for decreasing costs and improving access to cancer care – with particular relevance in low- and middle-resource settings although applicable in all settings. https://t.co/MkQx6Gzte4
— Julie Gralow (@jrgralow) February 10, 2021
RCT: The effect of daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, and function in healthy older adults
11 Feb, 2021 | 01:58h | UTCThe effect of daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, and function in healthy older adults: A randomized controlled trial – The American Journal of Clinical Nutrition (link to abstract – $ for full-text)
Commentary on Twitter
Daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, and function in healthy older adults: A randomized controlled trial https://t.co/sT81S8JfNs
No effect of protein supplementation in older persons, but lifting is good!
— Stuart Phillips (@mackinprof) February 10, 2021
Meta-analysis: Chlorthalidone vs. hydrochlorothiazide
11 Feb, 2021 | 02:00h | UTCChlorthalidone versus hydrochlorothiazide: major cardiovascular events, blood pressure, left ventricular mass, and adverse effects – Journal of Hypertension (link to abstract – $ for full-text)
Commentary: Chlorthalidone Compared With HCTZ for MACE Reduction – Renal & Urology News
Red Yeast Rice for Hypercholesterolemia: JACC Focus Seminar
11 Feb, 2021 | 01:54h | UTC
Guidelines for extracorporeal cardiopulmonary resuscitation in children and adults
11 Feb, 2021 | 01:48h | UTCSee also: Pediatric Extracorporeal Cardiopulmonary Resuscitation ELSO Guidelines – ASAIO Journal
Commentary on Twitter
#ECPR in adults @ELSOOrg guidelines
?pt selection, timing & location
?rationale for VA #ECPR
?cannula/cannulation
?#ACLS modifications
?establishing #ECMO & specific post CA care
?coronary angiography/PCI & imaging
?weaning@asaiojournal #FOAMecmo https://t.co/uDrPuSTTpg pic.twitter.com/A1ri9mn56s— M Velia Antonini (@FOAMecmo) February 1, 2021
Combination of vancomycin plus piperacillin and risk of acute kidney injury: a worldwide pharmacovigilance database analysis
11 Feb, 2021 | 01:50h | UTCRelated: Risk of acute kidney injury and Clostridioides difficile infection with piperacillin/tazobactam, cefepime and meropenem with or without vancomycin – Clinical Infectious Diseases AND Vancomycin Plus Piperacillin-Tazobactam and Acute Kidney Injury in Adults: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text) AND Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin/Tazobactam Treatment Among Hospitalized Children – JAMA Pediatrics (link to abstract – $ for full-text) AND Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients – Critical Care
Commentary on Twitter
? New paper from our team @HopitalCochin ⤵️
New data supporting a drug-drug interaction between vancomycin and piperacillin ⚠️ increased risk of acute kidney injury | Great collab with @AdrienContejean@KerneisSolen
Read more in @BSACandJAC ⤵️https://t.co/eQW5s52fOY@ABsteward— Laurent Chouchana (@LChouchana) February 1, 2021
RCT: Among patients undergoing transurethral resection of the prostate, it is safe to withhold antimicrobial prophylaxis for those without pre-operative pyuria or a pre-operative, indwelling catheter
11 Feb, 2021 | 01:52h | UTC
CDC Analysis: Effectiveness of mask wearing to control community spread of SARS-CoV-2
11 Feb, 2021 | 02:22h | UTCEffectiveness of Mask Wearing to Control Community Spread of SARS-CoV-2 – JAMA
Author interview: Mask Wearing for COVID-19 Prevention—Summary of CDC Data
With emergence of more transmissible #SARSCoV2 variants it is even more important to adopt widespread mask wearing and to redouble use of other nonpharmaceutical prevention measures until effective levels of vaccination are achieved nationally https://t.co/TSuh8Vjc29 @CDCgov
— JAMA (@JAMA_current) February 10, 2021
CDC Guidance: Improve the fit and filtration of your mask to reduce the spread of COVID-19
11 Feb, 2021 | 02:21h | UTC
CDC study on practical ways for maximizing fit for masks to reduce SARS-CoV-2 transmission and exposure
11 Feb, 2021 | 02:25h | UTCCommentaries: CDC Says Double-Masking Offers More Protection Against The Coronavirus – NPR AND CDC report: Double-masking can block more than 90 percent of viral particles – NBC News
Case report: Severe reinfection with South African SARS-CoV-2 variant
11 Feb, 2021 | 02:17h | UTC
Commentary on Twitter
?NEW Case report ?#CID @IDSAInfo
Severe reinfection with South African SARS-CoV-2 501Y.V2 lineage B.1.351 variant four months after a first mild infection. @InfectiousDz https://t.co/zjjJED4r0D— Antibiotic Steward? Bassam Ghanem (@ABsteward) February 10, 2021
Small RCT: Inhaled budesonide reduces the need for hospitalization in COVID-19 patients
11 Feb, 2021 | 02:18h | UTCCommentaries: Common asthma treatment reduces need for hospitalisation in COVID-19 patients, study suggests – University of Oxford AND Expert reaction to preprint on an RCT of inhaled budesonide in the treatment of early COVID-19 – Science Media Centre
WHO experts recommend AstraZeneca COVID vaccine across all ages and countries
11 Feb, 2021 | 02:20h | UTCCommentaries: WHO Experts Recommend AstraZeneca COVID Vaccine Across All Ages & Countries – Signal For Start Of Global COVAX Vaccine Rollout – Health Policy Watch AND WHO backs use of Oxford/AstraZeneca Covid vaccine for adults of all ages – The Guardian AND Covid: WHO backs Oxford vaccine ‘even if variants present’ – BBC AND Expert reaction to WHO recommending use of the Oxford/AstraZeneca COVID-19 vaccine, including in over 65s – Science Media Centre AND Up Against Mutants, WHO Says AstraZeneca Vaccine Is Still A Good Bet – NPR
ACP: Update on Remdesivir use for hospitalized COVID-19 patients
11 Feb, 2021 | 02:15h | UTC
Perspective: Leave your antibodies alone
11 Feb, 2021 | 02:12h | UTCLeave Your Antibodies Alone – The Atlantic
Researchers investigate What COVID-19 does to the heart
11 Feb, 2021 | 02:14h | UTCResearchers Investigate What COVID-19 Does to the Heart – JAMA
Definitely not the flu: risk of death from COVID-19 3.5 times higher than from flu
11 Feb, 2021 | 02:11h | UTCNews release: Definitely not the flu: risk of death from COVID-19 3.5 times higher than from flu
Original study: Characteristics and outcomes of hospital admissions for COVID-19 and influenza in the Toronto area – Canadian Medical Association Journal