Daily Archives: January 26, 2021
Randomized trial: Remote, online support for blood pressure management at home is effective and low-cost
26 Jan, 2021 | 00:46h | UTC
Commentary on Twitter
NEW #BMJresearch has found that a digital intervention for the management of hypertension by using self-monitored blood pressure led to better control of systolic blood pressure after one year than usual care, with low incremental costs @RichardJMcManus https://t.co/XiNCzE0t6C
— The BMJ (@bmj_latest) January 23, 2021
10-year follow up of a randomized trial shows metabolic surgery is more effective than conventional medical therapy for the control of type 2 diabetes
26 Jan, 2021 | 00:44h | UTCMetabolic surgery versus conventional medical therapy in patients with type 2 diabetes: 10-year follow-up of an open-label, single-centre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Podcast: Smoking Cessation Unfiltered
26 Jan, 2021 | 00:41h | UTC
Nurse Home Visiting and Maternal Mental Health: 3-Year Follow-Up of a Randomized Trial
26 Jan, 2021 | 00:42h | UTCNurse Home Visiting and Maternal Mental Health: 3-Year Follow-Up of a Randomized Trial – Pediatrics (link to abstract – $ for full-text)
Cohort study: Association of maternal autoimmune disease with Attention-Deficit/Hyperactivity Disorder in children
26 Jan, 2021 | 00:40h | UTCAssociation of Maternal Autoimmune Disease With Attention-Deficit/Hyperactivity Disorder in Children – JAMA Pediatrics (free for a limited period)
Editorial: More Evidence Linking Autoimmune Diseases to Attention-Deficit/Hyperactivity Disorder (free for a limited period)
Commentary: Risk of ADHD may increase if expectant mother has autoimmune disorder, study says – CNN AND Study Suggests Maternal Autoimmune Disease Linked to ADHD in Children – Physician’s Weekly AND Maternal Autoimmune Diseases Linked to ADHD in Children – NEJM Journal Watch
Commentary on Twitter
Maternal autoimmune disease has been associated with increased risk of neurodevelopmental disorders such as autism in offspring. A new study at #jamapeds reports a similar association for offspring development of ADHD. https://t.co/Kcm1hhXkHh pic.twitter.com/DBNvhATtX2
— JAMA Pediatrics (@JAMAPediatrics) January 20, 2021
Randomized trial: Clozapine vs. Olanzapine vs. Haloperidol in the treatment of violence in schizophrenia
26 Jan, 2021 | 00:33h | UTCThe Importance of Conduct Disorder in the Treatment of Violence in Schizophrenia: Efficacy of Clozapine Compared With Olanzapine and Haloperidol – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentary on Twitter (thread – Click for more)
RCT: In physically assaultive schizophrenia patients clozapine was superior to haloperidol and olanzapine in reducing assaults; olanzapine was superior to haloperidol https://t.co/RrX6VPubgL
— PfOL (@psychopharmacol) January 25, 2021
Cohort study: Association of potent and very potent topical corticosteroids and the risk of osteoporosis and major osteoporotic fractures
26 Jan, 2021 | 00:38h | UTCEditorial: Topical Corticosteroids and Glucocorticoid-Induced Osteoporosis—Cumulative Dose and Duration Matter
Commentaries: Prolonged Use of Topical Steroids Associated with Increased Risk of Osteoporosis – Physician’s Weekly AND Potent Topical Corticosteroids Tied to Increased Fracture Risk – NEJM Journal Watch
Author Interview: Association of Topical Corticosteroids and Risk of Osteoporosis and Major Osteoporotic Fractures – JAMA
Commentary on Twitter
In a cohort study of 723 251 users of potent or very potent topical #corticosteroids, use of these drugs was associated with increased risk of #osteoporosis and major osteoporotic fracture with a dose-response association for cumulative use https://t.co/m5Rp4n0NvK
— JAMA Dermatology (@JAMADerm) January 20, 2021
Preliminary study shows sitagliptin may prevent acute Graft-versus-Host Disease
26 Jan, 2021 | 00:35h | UTCDipeptidyl Peptidase 4 Inhibition for Prophylaxis of Acute Graft-versus-Host Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Sitagliptin promising addition for preventing acute GVHD – HealthDay
Cohort study: Aspirin linked to reduced risk of colon cancer if you start it before age 70
26 Jan, 2021 | 00:37h | UTCAspirin Use and Risk of Colorectal Cancer Among Older Adults – JAMA Oncology (free for a limited period)
Commentaries: Does aspirin lower colorectal cancer risk in older adults? It depends on when they start – Massachusetts General Hospital AND Aspirin Use Cuts CRC Risk in Those Initiating Use Before Age 70 – Physician’s Weekly
Randomized trial: In patients with colorectal peritoneal metastases, adding hyperthermic intraperitoneal chemotherapy to cytoreductive surgery does not improve survival and causes more frequent late complications
26 Jan, 2021 | 00:34h | UTCCytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary on Twitter
New online: PRODIGE 7 – #Cytoreductive #surgery plus hyperthermic intraperitoneal chemotherapy #HIPEC versus cytoreductive surgery alone for colorectal peritoneal metastases https://t.co/NuGwVmAnbt pic.twitter.com/NLk1DwwIXM
— The Lancet Oncology (@TheLancetOncol) January 19, 2021
Covid-19 vaccine tracker: The global race to vaccinate
26 Jan, 2021 | 00:59h | UTCCovid-19 vaccine tracker: the global race to vaccinate – Financial Times
See also: Coronavirus (COVID-19) Vaccinations – Our World in Data
Commentary on Twitter
Israel appears to be the only country that was ready for the vaccines. https://t.co/MPCqNdzi97 pic.twitter.com/bTT8zDpDDF
— Julia Belluz (@juliaoftoronto) January 25, 2021
Report: UK variant of Coronavirus possibly more deadly
26 Jan, 2021 | 00:58h | UTCNERVTAG paper on COVID-19 variant of concern B.1.1.7
Commentaries: Coronavirus: UK variant ‘may be more deadly’ – BBC AND CDC reviewing new data that suggests coronavirus variant identified in UK could be more deadly – CNN
Why scientists are more worried about the Covid-19 variant discovered in South Africa
26 Jan, 2021 | 00:56h | UTCWhy scientists are more worried about the Covid-19 variant discovered in South Africa – Vox
Original study (preprint and commentaries): South African COVID-19 variant escapes neutralization by antibodies in COVID-19 convalescent plasma
See also: Fast-spreading COVID variant can elude immune responses – Nature
Commentary on Twitter
Hot off the preprint press: Another new study, from the excellent @rjlessells @Tuliodna, used live virus to show that South Africa #coronavirus 501Y.V2 can in vitro escape antibody response from prior infectionhttps://t.co/mrryWtnXUu
Context here: https://t.co/V6WVSbUQGk
— Julia Belluz (@juliaoftoronto) January 22, 2021
[Press release – not published yet] Azithromycin and doxycycline are not generally effective against COVID-19 in patients treated at home, shows PRINCIPLE trial
26 Jan, 2021 | 01:03h | UTC
NCCN shares new guidance principles for vaccinating people with cancer against COVID-19
26 Jan, 2021 | 00:47h | UTCOriginal guideline: Preliminary Recommendations of the NCCN COVID-19 Vaccination Advisory Committee
Commentary: NCCN Shares New Recommendations for Vaccinating Patients With Cancer Against COVID-19 – The ASCO Post
Moderna COVID-19 vaccine may be less effective against variant found in South Africa
26 Jan, 2021 | 00:54h | UTCModerna Finds COVID-19 Vaccine Less Effective Against Variant Found In South Africa – NPR
Moderna Press release: Moderna COVID-19 Vaccine Retains Neutralizing Activity Against Emerging Variants First Identified in the U.K. and the Republic of South Africa
See also: Expert reaction to preprint from Moderna about neutralising activity of their vaccine against new variants and announcement of plans to trial a variant booster jab targeting the South African (B.1.351) variant – Science Media Centre AND Moderna Launches Trial For Covid-19 Vaccine Booster To Tackle South African Strain – Forbes
Commentary on Twitter
?Moderna preprint PUBLISHED?
A six-fold reduction in neutralizing titers was observed with B.1.351 variant relative to prior variants Despite this reduction, neutralizing titer levels with B.1.351 remain above levels that are expected to be protective https://t.co/pDfgRn6Ost pic.twitter.com/VLu3iOqAda— Antibiotic Steward? Bassam Ghanem (@ABsteward) January 25, 2021
New analysis does not support a major role of school reopening in the second COVID-19 wave in Israel
26 Jan, 2021 | 00:52h | UTC
Commentary on Twitter
Very interesting paper
Despite previous certainty about schools being the driving factor in the second wave in Israel, now looks unlikely
Easing restrictions of large gatherings in adults the predominant factor
Young adults, not children, as elsewherehttps://t.co/oWHbZynRpL
— Alasdair Munro (@apsmunro) January 25, 2021
UNICEF Executive Director Statement: “Children cannot afford another year of school disruption”
26 Jan, 2021 | 00:53h | UTCChildren cannot afford another year of school disruption – UNICEF
Commentary on Twitter
"Children cannot afford another year of school disruption."
Statement by UNICEF Executive Director @unicefchief Henrietta H. Fore
Find out more ?https://t.co/DwuaHGub3B pic.twitter.com/jQbdLK2EE5
— UNICEF Rwanda (@unicefrw) January 13, 2021
German study provides evidence that opening schools may be safe
26 Jan, 2021 | 00:51h | UTCGerman Study Provides Evidence that Opening Schools May Be Safe – Physician’s Weekly
Original Study: Prevalence of SARS-CoV-2 Infection in Children and Their Parents in Southwest Germany – JAMA Pediatrics
Editorial: To Spread or Not to Spread SARS-CoV-2—Is That the Question?
Related: Three studies highlight low COVID risk of in-person school
WHO COVAX Announces new agreement, plans for first deliveries
26 Jan, 2021 | 00:49h | UTCCOVAX Announces new agreement, plans for first deliveries – World Health Organization
Commentary on Twitter
#COVAX has signed an agreement with Pfizer/BioNTech for up to 40M doses of its #COVID19 vaccine.
We also expect to distribute almost 150M doses of the AstraZeneca/Oxford vaccine in the 1/4 of 2021, once the vaccine is listed for emergency use by @WHO. https://t.co/yx3FFl9bv8— Tedros Adhanom Ghebreyesus (@DrTedros) January 23, 2021