Daily Archives: January 21, 2021
Contradicting earlier trials, Tocilizumab did not improve outcomes, with signs of harm, in patients with severe Covid-19
21 Jan, 2021 | 01:46h | UTCCommentaries: Conflicting COVID-19 results for Roche arthritis drug show more trials needed – Reuters AND Covid-19: Arthritis drug trial for severe illness is stopped early after increase in deaths – The BMJ
Related research (study and commentaries): [Preprint] Randomized trial: Arthritis drugs improve survival in critically ill patients with Covid-19
‘A bloody mess’: Confusion reigns over naming of new COVID variants
21 Jan, 2021 | 01:27h | UTC‘A bloody mess’: Confusion reigns over naming of new COVID variants – Nature
[Preprint] South African COVID-19 variant escapes neutralization by antibodies in COVID-19 convalescent plasma
21 Jan, 2021 | 01:28h | UTCSARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma – bioRxiv
Commentaries: Expert reaction to preprint reporting that the South African SARS-CoV-2 variant 501Y.V2 escapes neutralisation by COVID-19 donor plasma – Science Media Centre AND S.Africa virus strain poses ‘re-infection risk’: study – MedicalXpress
5 reasons to wear a mask even after you’re vaccinated
21 Jan, 2021 | 01:24h | UTC5 Reasons to Wear a Mask Even After You’re Vaccinated – Kaiser Health News
COVID’s toll on smell and taste: what scientists do and don’t know
21 Jan, 2021 | 01:26h | UTCCOVID’s toll on smell and taste: what scientists do and don’t know – Nature
Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus
21 Jan, 2021 | 01:19h | UTC
Vaccinology in the post−COVID-19 era
21 Jan, 2021 | 01:24h | UTCVaccinology in the post−COVID-19 era – Proceedings of the National Academy of Sciences
Cohort study: Recipients of hematopoietic stem-cell transplantation who develop COVID-19 have poor overall survival
21 Jan, 2021 | 01:18h | UTC
Randomized trial: Similar outcomes with lower vs. higher oxygenation targets for acute hypoxemic respiratory failure
21 Jan, 2021 | 01:16h | UTCLower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Even though supplemental oxygen is used for the treatment of patients with hypoxemic respiratory failure, the most effective oxygenation targets are not known. In this randomized trial, a lower oxygenation target did not result in lower mortality than a higher target.
— NEJM (@NEJM) January 21, 2021
Allocating scarce intensive care resources during the COVID-19 pandemic: practical challenges to theoretical frameworks
21 Jan, 2021 | 01:22h | UTC
COVID-19 testing: One size does not fit all
21 Jan, 2021 | 01:21h | UTCCOVID-19 testing: One size does not fit all – Science
Commentary on Twitter
COVID-19 testing: One size does not fit all https://t.co/zduxAcrMAA An excellent article by @michaelmina_lab and Kristian Andersen discussing the differences between diagnostic testing, surveillance testing and screening testing.
— Carlos del Rio (@CarlosdelRio7) January 8, 2021
State of the art review: Management of non-alcoholic fatty liver disease
21 Jan, 2021 | 01:13h | UTCManagement of non-alcoholic fatty liver disease – The BMJ
Thrombolytic strategies versus standard anticoagulation for acute deep vein thrombosis of the lower limb
21 Jan, 2021 | 01:10h | UTCSummary: Thrombolysis for treatment of acute deep vein thrombosis – Cochrane Library
Randomized trial: Oral Rimegepant for preventive treatment of migraine
21 Jan, 2021 | 01:04h | UTCOral rimegepant for preventive treatment of migraine: a phase 2/3, randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary: Rimegepant bests placebo for preventing migraine – MedicalXpress
Against placebo? It would be interesting to know how this new drug works against other established treatments.
Randomized trial: In pediatric acute CNS infections, 3% Hypertonic saline is superior to 20% Mannitol for reducing intracranial pressure
21 Jan, 2021 | 01:08h | UTCRandomized Clinical Trial of 20% Mannitol Versus 3% Hypertonic Saline in Children With Raised Intracranial Pressure Due to Acute CNS Infections – Pediatric Critical Care Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Feature w/#VisualAbstract
RCT of 20% mannitol vs. 3% hypertonic saline in children w/raised ICP due to acute CNS infections: Which is superior?
Rameshkumar, @drarunbansal, Jayashree ??: https://t.co/ZGWaPMhPvr
Editorial by Argent ??: https://t.co/BsbZKsEG03#PedsICU @WFPICCS pic.twitter.com/5asM9HNQaN
— Pediatric Critical Care Medicine (@PedCritCareMed) December 21, 2020
Randomized trial: Repeated Ketamine administration for chronic posttraumatic stress disorder
21 Jan, 2021 | 01:03h | UTCA Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder – The American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Repeated Ketamine Infusions Reduce Symptom Severity in Individuals With Chronic Post-Traumatic Stress Disorder – Mount Sinai AND Repeated Ketamine Infusions May Rapidly Reduce Chronic PTSD Symptoms – Psychiatry News Alert
Commentary on Twitter
Patients with chronic PTSD given repeated infusions of ketamine over 2 weeks showed significantly greater symptom improvement than those given a psychoactive placebo control infusion, the first evidence of efficacy.
Learn More: https://t.co/qqcIsNfCHC pic.twitter.com/r7Bggz4cIj— Journals of The American Psychiatric Association (@APAPubJournals) January 5, 2021
Meta-analysis: Perioperative systemic dexamethasone reduces length of stay in total joint arthroplasty
21 Jan, 2021 | 01:52h | UTCPerioperative Systemic Dexamethasone Reduces Length of Stay in Total Joint Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – The Journal of Arthroplasty (link to abstract – $ for full-text)
Acute flaccid myelitis: Cause, diagnosis, and management
21 Jan, 2021 | 00:58h | UTCAcute flaccid myelitis: cause, diagnosis, and management – The Lancet (free registration required)
Randomized non-inferiority study: Long-acting cabotegravir and rilpivirine dosed every 2 months in adults with HIV-1 infection
21 Jan, 2021 | 01:01h | UTCLong-acting cabotegravir and rilpivirine dosed every 2 months in adults with HIV-1 infection (ATLAS-2M), 48-week results: a randomised, multicentre, open-label, phase 3b, non-inferiority study – The Lancet (link to abstract – $ for full-text)
Commentary (thread – click for more)
Long-acting cabotegravir and rilpivirine dosed every 2 months in adults with #HIV-1 infection (ATLAS-2M), 48-week results: a randomised, multicentre, open-label, phase 3b, non-inferiority study: https://t.co/4SdfnRRCje
— The Lancet (@TheLancet) December 21, 2020
Podcast: MGUS, Myeloma, and Immunology
21 Jan, 2021 | 00:53h | UTCMGUS, Myeloma, and Immunology – The Curbsiders Internal Medicine Podcast
Antenatal interventions for preventing stillbirth, fetal loss and perinatal death: an overview of Cochrane systematic reviews
21 Jan, 2021 | 00:59h | UTCCommentary: What are the most effective interventions during pregnancy for preventing stillbirth? – Cochrane Library
Commentary on Twitter
@CochranePCG overview of Cochrane systematic reviews included 43 Cochrane reviews that assessed 61 different ways of preventing stillbirth during pregnancy, or infant deaths around the time of birth. Read the feature https://t.co/ijf9Id8jjO & full review https://t.co/tMZsCVhs3m
— Cochrane Neonatal (@CochraneNeonate) January 7, 2021
Managing code status conversations for seriously ill older adults in respiratory failure
21 Jan, 2021 | 00:55h | UTC
Meta-Analysis: Low-intensity warfarin may be an option for patients under 65 years of age with non-valvular atrial fibrillation
21 Jan, 2021 | 00:57h | UTCMeta-Analysis Evaluating the Efficacy and Safety of Low-Intensity Warfarin for Patients >65 Years of Age With Non-Valvular Atrial Fibrillation – The American Journal of Cardiology (link to abstract – $ for full-text)
Case series: Portable Magnetic Resonance Imaging for ICU Patients
21 Jan, 2021 | 00:54h | UTCPortable Magnetic Resonance Imaging for ICU Patients – Critical Explorations
[Abstract Only] Meta-analysis: Ablation of aldosterone producing adenoma is associated with a reduced operative duration, decreased intraoperative blood loss, and faster postoperative recovery compared to laparoscopic adrenalectomy
21 Jan, 2021 | 00:50h | UTCAblation versus laparoscopic adrenalectomy for the treatment of aldosterone‑producing adenoma: a meta-analysis – Abdominal Radiology (link to abstract – $ for full-text)