Daily Archives: December 15, 2020
Consensus Guideline: Defining and managing COVID-19-associated pulmonary aspergillosis
15 Dec, 2020 | 01:42h | UTC
Perspective: How Science Beat the Virus – And what it lost in the process
15 Dec, 2020 | 01:40h | UTCHow Science Beat the Virus – The Atlantic
Commentary from the author on Twitter (thread – click for more)
?I wrote the Atlantic’s next cover story on the COVIDization of science. No other disease has been scrutinized so intensely, by so much combined intellect, in so brief a time. This piece is about both the victories achieved & the weaknesses exposed. 1/ https://t.co/RbL9mVHhEv
— Ed Yong (@edyong209) December 14, 2020
The coronavirus at 1: A year into the pandemic, what scientists know about how it spreads, infects, and sickens
15 Dec, 2020 | 01:42h | UTC
News Release: The Sputnik V vaccine’s efficacy is confirmed at 91.4% based on data analysis of the final control point of clinical trials
15 Dec, 2020 | 01:36h | UTC
[Preprint] RECOVERY trial: Azithromycin does not improve outcomes in hospitalized patients with COVID-19
15 Dec, 2020 | 01:44h | UTCNews release: RECOVERY trial finds no benefit from azithromycin in patients hospitalised with COVID-19
Commentary on Twitter
New RECOVERY result. In patients hospitalised with COVID-19, azithromycin did not provide any clinical benefit. 28 day mortality (19% vs 19%) (rate ratio 1·00; 95% confidence interval [CI] 0·90-1·12; p=0·99). No effect on secondary outcomes either.https://t.co/PTklz40WKr pic.twitter.com/NCzvRIND0S
— Peter Horby (@PeterHorby) December 14, 2020
Arab nations first to approve Chinese COVID vaccine — despite lack of public data
15 Dec, 2020 | 01:38h | UTCArab nations first to approve Chinese COVID vaccine — despite lack of public data – Nature
A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters
15 Dec, 2020 | 01:34h | UTCCommentary: Kids likely not driving household COVID-19 outbreaks – CIDRAP
Study: Children and adults equally susceptible to in-home COVID-19 spread, but children generally had less frequent and severe symptoms
15 Dec, 2020 | 01:36h | UTCCommentaries: Study: Kids, adults equally susceptible to in-home COVID-19 spread – CIDRAP AND COVID-19 in Children: Looking Forward, Not Back
WHO, UNICEF Report: Almost 2 billion people depend on health care facilities without basic water services
15 Dec, 2020 | 01:33h | UTC
Brazilian Cardio-oncology Guideline – 2020
15 Dec, 2020 | 01:31h | UTCBrazilian Cardio-oncology Guideline – 2020 – Arquivos Brasileiros de Cardiologia
Randomized trial: Among patients with advanced rectal cancer, short-course radiotherapy followed by chemotherapy before total mesorectal excision reduces disease-related treatment failure compared to standard treatment
15 Dec, 2020 | 01:29h | UTC
Commentary on Twitter
New online: phase 3 RAPIDO trial: Short-course #radiotherapy followed by #chemotherapy before total mesorectal excision (TME) vs standard of care in locally advanced #rectalcancer https://t.co/bTgUC6Lo39 #crcsm pic.twitter.com/Iu3HbQ1xjG
— The Lancet Oncology (@TheLancetOncol) December 8, 2020
AHA Scientific Statement: Menopause transition and cardiovascular disease risk
15 Dec, 2020 | 01:32h | UTCNews release: Heart disease risk in women increases leading up to menopause; early intervention is key – American Heart Association
Top Things to Know: Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention
Commentaries: Menopause Transition and Cardiovascular Health: Time Matters – American Heart Association AND Report on latest menopause science looks at heart risks – American Heart Association AND Menopause Transition and CVD Risk: AHA Scientific Statement – American College of Cardiology
Critical review: “I’m upset about the RELAX trial” (study showing a lower PEEP strategy is noninferior to a higher PEEP strategy in ICU patients without ARDS)
15 Dec, 2020 | 01:27h | UTCI’m upset about the RELAX trial – PulmCrit
Original study and commentaries: Randomized trial: Among patients in the ICU receiving invasive ventilation, a strategy with lower PEEP was noninferior to a strategy using higher PEEP
Commentary from the author on Twitter
RELAX trial
?♂️PEEP 8 cm vs. lowest possible PEEP (as low as zero!) among patients without ARDS
?♂️no difference in primary endpoints
?♂️low-PEEP caused lower PO2/FiO2 ratios, higher driving pressures, more need for rescue therapy ?https://t.co/fGFiQyn3jY pic.twitter.com/yi2hN3yBZi— ???? ?????? ? (@PulmCrit) December 14, 2020
Randomized trial: In acutely ill children, the risk of electrolyte disorders is markedly increased with plasmalike isotonic fluid therapy compared with moderately hypotonic fluid therapy containing 20 mmol/L of potassium
15 Dec, 2020 | 01:25h | UTCRisk of Electrolyte Disorders in Acutely Ill Children Receiving Commercially Available Plasmalike Isotonic Fluids: A Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)
Commentary: Isotonic Fluids Without Potassium Could Be Harmful for Some Acutely Ill Kids – Medscape (free registration required)
Commentary on Twitter
A randomized pragmatic clinical trial shows a high risk of #hypokalemia and a small risk of #hypernatremia in acutely ill children receiving plasma-like fluid therapy https://t.co/FOoJeaSSes @TerhiTapiainen
— JAMA Pediatrics (@JAMAPediatrics) October 27, 2020
Randomized trial: Among women with urinary incontinence, biofeedback-mediated intensive pelvic floor training does not provide additional benefit to basic pelvic floor muscle training
15 Dec, 2020 | 01:23h | UTC
Meta-analysis: Induction of labor at 41 weeks improves perinatal outcomes compared with expectant management until 42 weeks, without increasing the cesarean delivery rate
15 Dec, 2020 | 01:21h | UTC
Podcast: Management of Cellulitis
15 Dec, 2020 | 01:20h | UTC