Daily Archives: November 10, 2020
News Release [Not Published Yet]: Vaccine candidate 90% effective against Covid-19 according to manufacturer
10 Nov, 2020 | 09:41h | UTCNews Release: Pfizer and Biontech announce vaccine candidate against Covid-19 achieved success in first interim analysis from phase 3 study
Commentaries: What Pfizer’s landmark COVID vaccine results mean for the pandemic – Nature AND Covid-19: Vaccine candidate may be more than 90% effective, interim results indicate – The BMJ AND Covid vaccine: First ‘milestone’ vaccine offers 90% protection – BBC AND Hopes rise for end of pandemic as Pfizer says vaccine is 90% effective – The Guardian AND Four reasons for encouragement based on Pfizer’s Covid-19 vaccine results – STAT AND Expert reaction to Pfizer and BioNTech reporting interim results from phase 3 COVID-19 vaccine trial – Science Media Centre
Another study shows hydroxychloroquine does not benefit adults hospitalized with COVID-19
10 Nov, 2020 | 09:39h | UTCEditorial: Misguided Use of Hydroxychloroquine for COVID-19: The Infusion of Politics Into Science
Commentary: Hydroxychloroquine does not benefit adults hospitalized with COVID-19 – NIH News Releases
Patients with Covid-19 and myocardial injury have increased in-hospital mortality, particularly if echocardiographic abnormalities are present
10 Nov, 2020 | 09:37h | UTC
Report: Large cluster of cases during a long flight shows seating proximity was strongly associated with infection risk
10 Nov, 2020 | 09:38h | UTCTransmission of SARS-CoV 2 During Long-Haul Flight – Emerging Infectious Diseases
Related studies: In-Flight Transmission of SARS-CoV-2 – Emerging Infectious Diseases AND A large national outbreak of COVID-19 linked to air travel, Ireland, summer 2020 – Eurosurveillance
Commentaries: Coronavirus can spread on airline flights, two studies show – CNN AND Do Masks On Plane Flights Really Cut Your Risk Of Catching COVID-19? – NPR AND Is it worth the risk? A guide to navigating holiday travel during the pandemic University of Texas Health Science Center at Houston
Case reports: Multidrug-resistant Candida auris infections in critically ill Covid-19 patients
10 Nov, 2020 | 09:33h | UTCCommentaries: Candida auris Infection in COVID-19 Patients – NEJM Journal Watch AND Drug-resistant superbug thriving in hospitals hit hard by COVID-19 – National Geographic
In patients hospitalized with COVID-19, right ventricular dilation or dysfunction was independently associated with a >2-fold increase in risk for mortality
10 Nov, 2020 | 09:36h | UTCCommentaries: Utility of RV Remodeling Over Risk Stratification in COVID-19 – American College of Cardiology AND Damage to heart’s right ventricle predicts a greater chance of death from COVID-19 – Weill Cornell Medical College
Aspirin to be investigated as a possible treatment for COVID-19 in the RECOVERY trial
10 Nov, 2020 | 09:35h | UTCCommentary: Aspirin to be tested as potential COVID-19 drug in UK study – Reuters
[Abstract Only] Randomized trial: In patients with persistent atrial fibrillation, treatment with catheter ablation + vein of Marshall ethanol infusion increased the likelihood of remaining free of AF, compared with catheter ablation alone
10 Nov, 2020 | 09:32h | UTCEffect of Catheter Ablation With Vein of Marshall Ethanol Infusion vs Catheter Ablation Alone on Persistent Atrial Fibrillation: The VENUS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary on Twitter
VENUS: randomized trial of vein of Marshall ethanol added to catheter ablation of persistent AF. 13 years in the making… I hope to be faster next time! https://t.co/EfW8d4FOtu
— Miguel Valderrábano (@MiguelVldrbno) October 27, 2020
Systematic review: Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome. “At present, there are no convincing data supporting any specific inotropic or vasodilating therapy to reduce mortality in hemodynamically unstable patients with CS or LCOS.”
10 Nov, 2020 | 09:30h | UTC
Cohort study: Nighttime high blood pressure phenotype linked to worse cardiovascular prognosis
10 Nov, 2020 | 09:29h | UTCCommentaries: People who experience high blood pressure while sleeping have increased risk of heart attacks, strokes – News Medical / American Heart Association AND Sleeptime BP Spikes Tied to Heart Troubles – Physician’s Weekly
[Abstract Only]: Randomized trial: Drug-coated balloons non-inferior to drug-eluting stents for small coronary artery disease
10 Nov, 2020 | 09:27h | UTCLong-term efficacy and safety of drug-coated balloons versus drug-eluting stents for small coronary artery disease (BASKET-SMALL 2): 3-year follow-up of a randomised, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
NEW Research—Long-term efficacy and safety of drug-coated balloons vs drug-eluting stents for small coronary artery disease (BASKET-SMALL 2): 3-year follow-up of a randomised, non-inferiority trial https://t.co/Fmi4sZTSdU pic.twitter.com/UfznQp6gkh
— The Lancet (@TheLancet) October 20, 2020
Current and evolving standards of care for patients with acute respiratory distress syndrome (ARDS). Definition, ventilatory support, fluid management, use of corticosteroids, indications of prone positioning and ECMO, and more.
10 Nov, 2020 | 09:26h | UTCCurrent and evolving standards of care for patients with ARDS – Annals of Intensive Care
Commentary on Twitter
#ARDS current & evolving standards of care
➡️ definition 10y after Berlin
➡️ MV: P/volume limits; PEEP & recruitment; spontaneous breathing
➡️ adjuncts: proning; NMBAs; iNO; #ECMO
➡️ pharmacotherapy: steroids; fluids; specific agents
➡️ #COVID19#FOAMcc https://t.co/rXGsAs2M4D pic.twitter.com/6FRWXtBiME— Intens Care Med (@yourICM) November 7, 2020
Review: Use of multiple period, cluster randomized, crossover trial designs for comparative effectiveness research
10 Nov, 2020 | 09:22h | UTC
This article outlines the key methodological and ethical requirements needed for the robust design of multiple period, cluster randomised, crossover trialshttps://t.co/CMky7icWhY
— The BMJ (@bmj_latest) November 6, 2020
Perioperative evaluation and management of patients with diabetes, thyroid disease, and adrenal insufficiency. Use of insulin and noninsulin diabetic medications, management of hyper and hypothyroidism, and use of stress-dose corticosteroids are some of the subjects reviewed
10 Nov, 2020 | 09:24h | UTCPerioperative Evaluation and Management of Endocrine Disorders – Mayo Clinic Proceedings