Daily Archives: October 29, 2020
Randomized phase 2 trial: SARS-CoV-2 neutralizing antibody LY-CoV555 in outpatients with Covid-19
29 Oct, 2020 | 09:16h | UTCAudio Interview: A New Monoclonal Antibody for Covid-19 – New England Journal of Medicine
Commentaries on Twitter
BLAZE-1? – outpatient trial of LY-Cov555, mAb recently dropped from ACTIV-3 inpatient trial
Only 1 of the 3 mAb dosages (middle one ?♂️) ⬇️ VL by d11
mAb assoc with modest ⬇️ in healthcare visits (1.6% vs 6.3% for placebo)
? Far from a game changerhttps://t.co/zZMGlodaaF pic.twitter.com/ofs1UgN1ZA
— Ilan Schwartz MD PhD (@GermHunterMD) October 28, 2020
Phase 2 Lilly #SARSCoV2 monoclonal antibody outpatient trial just published @NEJM
The lack of a dose response for viral load reduction +modest effects on symptoms do not make this look like a potent intervention https://t.co/oyRG8fUNHf pic.twitter.com/uobuCIznmD— Eric Topol (@EricTopol) October 28, 2020
Humoral immune response to SARS-CoV-2 in Iceland
29 Oct, 2020 | 09:18h | UTCHumoral Immune Response to SARS-CoV-2 in Iceland – New England Journal of Medicine
Editorial: The Power of Antibody-Based Surveillance – New England Journal of Medicine
Video: Coronavirus update with Anthony Fauci – October 28, 2020
29 Oct, 2020 | 09:11h | UTCCoronavirus Update With Anthony Fauci – October 28, 2020 – JAMA
Clinical practice: Mild or moderate Covid-19
29 Oct, 2020 | 09:12h | UTCMild or Moderate Covid-19 – New England Journal of Medicine
What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2
29 Oct, 2020 | 09:09h | UTC
Commentary on Twitter
NEW—What defines an efficacious #COVID19 vaccine? Experts @JennerInstitute@OxfordVacGroup @OxPrimaryCare & @OxfordBRC outline key challenges for assessing clinical efficacy of vaccines against SARS-CoV-2 @TheLancetInfDis https://t.co/QsLnLdUiYE pic.twitter.com/skpb0rfSdF
— The Lancet (@TheLancet) October 28, 2020
Clinical Decisions: Elective surgery during the Covid-19 pandemic
29 Oct, 2020 | 09:14h | UTCElective Surgery during the Covid-19 Pandemic – New England Journal of Medicine
Randomized trial: Validation of an enhanced recovery after surgery protocol in gynecologic surgery
29 Oct, 2020 | 09:07h | UTCRelated Systematic Review: Multicomponent hospital-led interventions to reduce hospital stay for older adults following elective surgery: a systematic review – Health Services and Delivery Research AND Summary: People leave hospital after surgery sooner if hospitals follow ‘enhanced recovery protocols’ – NIHR
See also: Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines (free articles)
Commentary on Twitter
Validation of an enhanced recovery after surgery protocol in gynecologic surgery: an Italian randomized study- https://t.co/VRZ1LKzEvJ pic.twitter.com/2G1InEcIEZ
— AJOG (@AJOG_thegray) October 27, 2020
Report: Robust neutralizing antibodies to SARS-CoV-2 infection persist for months
29 Oct, 2020 | 09:08h | UTCRobust neutralizing antibodies to SARS-CoV-2 infection persist for months – Science
Commentary on Twitter
Just published @ScienceMagazine. >30,000 people w/mild to moderate #COVID19 have excellent IgG antibody titers for several months. No disappearing act. Important??https://t.co/4kCZY8qcmo @MountSinaiNYC @FatimaAmanat @DrDavidReich @florian_krammer @IcahnMountSinai et al
, pic.twitter.com/B3LJ6JaBDa— Eric Topol (@EricTopol) October 28, 2020
Randomized trial: Osimertinib in resected EGFR-Mutated non–small-cell lung cancer
29 Oct, 2020 | 09:04h | UTCOsimertinib in Resected EGFR-Mutated Non–Small-Cell Lung Cancer – New England Journal of Medicine
A systematic review of rehabilitation and exercise recommendations in oncology guidelines
29 Oct, 2020 | 09:02h | UTC
Commentary on Twitter
Improving the integration of rehabilitation into cancer care: A review of #oncology guidelines and their recommendations for #rehabilitation and #exercise https://t.co/QRerXhhGON #cancerehab #exerciseoncology @NicoleStoutPT @JulieSilverMD @KarenPhysio @DR_SantaMina @WVUCancer pic.twitter.com/kObsSMRN9A
— CA: A Cancer Journal for Clinicians (@CAonline) October 27, 2020
Systematic review: PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease
29 Oct, 2020 | 08:57h | UTCSummary: PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library
The ‘Ten Commandments’ in the new ESC Adult Congenital Heart Disease Guidelines
29 Oct, 2020 | 08:59h | UTCOriginal guideline and commentaries: 2020 ESC Guidelines for the management of adult congenital heart disease
Podcast – Sinusitis: It’s Not That Tricky
29 Oct, 2020 | 08:55h | UTC#239 Sinusitis: It’s Not That Tricky – The Curbsiders Internal Medicine Podcast
Ten tips to optimize weaning and extubation success in the critically ill
29 Oct, 2020 | 08:50h | UTCTen tips to optimize weaning and extubation success in the critically ill – Intensive Care Medicine
Commentary on Twitter
Wean/extubate critically ills
1⃣optimize (⬇️) sedation
2⃣diaphragm-protective MV
3⃣daily screen for SBT
4⃣best SBT?
5⃣weaning strategy
6⃣what if SBT fails
7⃣muscle load/efficiency ratio
8⃣weaning/extubation failure
9⃣post-extubation support
? tracheostomyhttps://t.co/TaYdzMvisK pic.twitter.com/q9qQOVKioZ— Intens Care Med (@yourICM) October 27, 2020