Daily Archives: October 1, 2020
Randomized trial: Hydroxychloroquine vs. placebo for pre-exposure SARS-CoV-2 prophylaxis among health care workers
1 Oct, 2020 | 09:17h | UTCCommentary: Hydroxychloroquine didn’t prevent COVID-19 among health care workers in new study – CNN
Commentary on Twitter
#Hydroxychloroquine taken daily by hospital-based health care providers over 8 weeks did not prevent #SARSCoV2 infection, in a double-blind randomized placebo-controlled trial performed at 2 University of Pennsylvania hospitals https://t.co/7XHn6uBh4Z
— JAMA Internal Medicine (@JAMAInternalMed) September 30, 2020
This overlooked variable is the key to the pandemic. It’s k, the dispersion factor, not R.
1 Oct, 2020 | 09:12h | UTCThis Overlooked Variable Is the Key to the Pandemic. It’s not R. – The Atlantic
Commentary on Twitter
It's k, the dispersion factor, not R. @zeynep's ★ synthesis of the opportunity to get ahead of the virus by taking advantage of the 80/20 rule for how it spreads, the avoidance of superspreading (not overlooked by me; a compelling case here)https://t.co/dZSHHdkOTA @TheAtlantic
— Eric Topol (@EricTopol) September 30, 2020
COVID has killed more than one million people. How many more will die?
1 Oct, 2020 | 09:13h | UTCCOVID has killed more than one million people. How many more will die? – Nature
Commentary on Twitter
Researchers warn that official figures underestimate the pandemic’s real death toll, which could more than triple if the virus is allowed to spread unchecked. https://t.co/H9hbI38ZEa
— Nature News & Comment (@NatureNews) September 30, 2020
Recommendations for antibacterial therapy in adults with COVID-19 – An evidence based guideline
1 Oct, 2020 | 09:15h | UTC
Commentary on Twitter
?Just published?@CMIJournal
Recommendations for antibacterial therapy in adults with COVID-19 – An evidence based guideline by the Dutch Working Party on Antibiotic Policy. #IDTwitter #COVID19 https://t.co/7cfZtS6Duv pic.twitter.com/Kz7CPMNLmh— Antibiotic Steward? Bassam Ghanem (@ABsteward) September 30, 2020
The evolving picture of SARS-CoV-2 and COVID-19 in children: critical knowledge gaps
1 Oct, 2020 | 09:09h | UTC
Commentary on Twitter
The evolving picture of SARS-CoV-2 and COVID-19 in children: critical knowledge gapshttps://t.co/vPWuNytBPP pic.twitter.com/pbLY1m9ZD2
— BMJ Global Health (@GlobalHealthBMJ) September 30, 2020
Audio interview: Covid-19 testing and the individual physician
1 Oct, 2020 | 09:11h | UTCAudio Interview: Covid-19 Testing and the Individual Physician – New England Journal of Medicine
Perspective: Rethinking Covid-19 test sensitivity — a strategy for containment
1 Oct, 2020 | 09:10h | UTCRethinking Covid-19 Test Sensitivity — A Strategy for Containment – New England Journal of Medicine
Keeping best practices in critical care during COVID-19
1 Oct, 2020 | 09:08h | UTCKeeping Best Practices in Critical Care During COVID-19 – ICU Management & Practice
Commentary on Twitter
COVID-19 poses several challenges and has made it difficult to measure ICU performance.
Read the article 'Keeping Best Practices in Critical Care During COVID-19' by @f_g_zampieri ?https://t.co/kvwlGSLBav#Covid19 #ICU #patientoutcome #FOAMcc #FOAMed pic.twitter.com/2YOhOnidxZ
— ICU Management (@ICU_Management) September 28, 2020
A systematic review and meta-analysis of published research data on COVID-19 infection-fatality rates
1 Oct, 2020 | 09:04h | UTC
Commentary on Twitter
(1/3) Excellent, rigorous review and meta-analysis of #COVID19 infection fatality ratio (IFR).
The overall IFR was 0.68% (95% CI 0.53-0.82%).
If only studies with a low risk of bias were included, the IFR rose to 0.76% (0.37-1.15%).https://t.co/F5GN0253lz https://t.co/7ucGgQ78AM pic.twitter.com/laHO3e4sl3
— Dr Zoë Hyde (@DrZoeHyde) September 30, 2020
Viewpoint: COVID-19 and heart failure with preserved ejection fraction
1 Oct, 2020 | 09:06h | UTCCOVID-19 and Heart Failure With Preserved Ejection Fraction – JAMA
New research shows older adults are still often excluded from clinical trials
1 Oct, 2020 | 09:02h | UTCNew research shows older adults are still often excluded from clinical trials – STAT
Original Study: The Exclusion of Older Persons From Vaccine and Treatment Trials for Coronavirus Disease 2019—Missing the Target – JAMA Internal Medicine
Commentary on Twitter
“It is important we have a trial population that reflects the real-world population." https://t.co/tRpo0NGL5x
— STAT (@statnews) October 1, 2020
[Abstract Only] Atezolizumab for first-line treatment of PD-L1–selected patients with non–small-cell lung cancer
1 Oct, 2020 | 08:53h | UTCCommentary: Atezolizumab Leads to Longer OS for Some Types of Advanced NSCLC, Study Says – AJMC
Invasive candidiasis in critical care: Challenges and future directions
1 Oct, 2020 | 09:00h | UTCInvasive candidiasis in critical care: challenges and future directions – Intensive Care Medicine
Commentary on Twitter
Invasive candidiasis: most common #ICU fungal infection ~40-55% mortality. Key challenges:
➡️ changing epidemiology/emergence of resistances
➡️ timely/appropriate therapy initiation/discontinuation
➡️ choosing/tailoring optimal antifungals#FOAMcc review https://t.co/tMPNcYfzwL pic.twitter.com/HvJKr0jX2o— Intens Care Med (@yourICM) September 30, 2020
Systematic review: The effectiveness and cost‐effectiveness of hospital‐based specialist palliative care for adults with advanced illness and their caregivers
1 Oct, 2020 | 08:58h | UTC
Commentary on Twitter
Cochrane review on hospital-based specialist palliative care. Findings: Improved HR-QoL and patient satisfaction, reduced symptom burden and depression, and increased chances of patients dying in their preferred place. @SBajwah @cochranecollab https://t.co/wjhGp0gcbs
— Olaf Geerse (@OlafGeerse) September 30, 2020
[Abstract Only] Nationwide cohort study in Sweden shows HPV vaccination linked to reduced risk of invasive cervical cancer
1 Oct, 2020 | 08:56h | UTCHPV Vaccination and the Risk of Invasive Cervical Cancer – New England Journal of Medicine
News Release: HPV vaccine effective against cervical cancer – Karolinska Institutet