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Daily Archives: May 25, 2020

Remdesivir for the Treatment of Covid-19 — Preliminary Report

25 May, 2020 | 02:06h | UTC

Remdesivir for the Treatment of Covid-19 — Preliminary Report – New England Journal of Medicine

Commentaries: Preliminary report on NIAID trial of remdesivir – PulmCrit AND Peer-reviewed data shows remdesivir for COVID-19 improves time to recovery – National Institutes of Health AND Covid-19 study details benefits of treatment with remdesivir, and also its limitations – STAT

 

Related Commentary on Twitter (Thread – Click for more)

 


Perspective: The World May Be Overestimating the Power of Vaccines

25 May, 2020 | 01:55h | UTC

The world needs Covid-19 vaccines. It may also be overestimating their power – STAT

 


Hydroxychloroquine and Chloroquine for Covid-19: Large Observational Analysis Finds No Benefit and Possible Harm

25 May, 2020 | 02:03h | UTC

Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis – The Lancet

Commentaries: Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous? – The Lancet AND What a big new study on malaria drugs as Covid-19 treatments tells us — and what it doesn’t – STAT AND Hydroxychloroquine May Cause More Harm Than Benefit To COVID-19 Patients, Says New Lancet Study – Health Policy Watch

 


Opinion: Why Countries Should Stop Using Anti-malarial Drugs for COVID-19

25 May, 2020 | 02:02h | UTC

Why countries should stop using anti-malarial drugs for COVID-19 – The Conversation

 


[Preprint] Meta-Analysis: Susceptibility to and Transmission of COVID-19 Amongst Children and Adolescents Compared with Adults

25 May, 2020 | 01:52h | UTC

Susceptibility to and transmission of COVID-19 amongst children and adolescents compared with adults: a systematic review and meta-analysis – medRxiv

Commentaries: Children appear half as likely to catch COVID-19 as adults – London School of Hygiene & Tropical Medicine AND Expert reaction to systematic review preprint looking at susceptibility to SARS-CoV-2 infection in children and adolescents compared with adults – Science Media Centre

 


Editorial – SARS-CoV2 Vaccines: Slow is Fast

25 May, 2020 | 01:54h | UTC

SARS-CoV2 vaccines: Slow is fast – Science

 


Promising Early Results with New Vaccine from China in Phase I Trial

25 May, 2020 | 01:57h | UTC

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial – The Lancet

Commentaries: First human trial of COVID-19 vaccine finds it is safe and induces rapid immune response – The Lancet AND Early Study Of Covid-19 Vaccine Developed In China Sees Mixed Results – Forbes AND Coronavirus Vaccine Shows Promising Early Results in China – The New York Times AND A Chinese biotech just published the first human data for its coronavirus vaccine candidate, supporting further trials – Business Insider AND Experts skeptical after researchers report positive vaccine results – CNN AND Two COVID-19 Vaccine Candidates Induce Immune Response In Healthy Volunteers – Health Policy Watch

 


SARS-CoV-2 RNA in Wastewater Anticipated COVID-19 Occurrence in a Low Prevalence Area

25 May, 2020 | 01:47h | UTC

SARS-CoV-2 RNA in wastewater anticipated COVID-19 occurrence in a low prevalence area – Water Research

Related: New Research Examines Wastewater to Detect Community Spread of Covid-19

 


Study: 10 of 60 Patients Treated for COVID-19 Persisted with Positive RT-PCR Results from 4 to 24 Days After Hospital Discharge

25 May, 2020 | 01:50h | UTC

Coronavirus Disease 2019 Test Results After Clinical Recovery and Hospital Discharge Among Patients in China – JAMA Network Open

Commentaries: Expert reaction to study on PCR testing results from 60 people after clinical recovery from COVID-19 – Science Media Centre AND 16% of recovered patients test positive for COVID-19 weeks after discharge: study – UPI

 


Systematic Review: Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19

25 May, 2020 | 01:40h | UTC

Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19: A Living Systematic Review of Multiple Streams of Evidence – Annals of Internal Medicine

 


Meta-Analysis: Corticosteroids May Reduce Mortality for Patients with COVID-19 and ARDS

25 May, 2020 | 01:45h | UTC

Efficacy and safety of corticosteroids in COVID-19 based on evidence for COVID-19, other coronavirus infections, influenza, community-acquired pneumonia and acute respiratory distress syndrome: a systematic review and meta-analysis – Canadian Medical Association Journal

Related: Early Short Course Corticosteroids in Hospitalized Patients with COVID-19 – Clinical Infectious Diseases

 


Clinical Guidance: Thromboembolism and Anticoagulant Therapy During the COVID-19 Pandemic

25 May, 2020 | 01:43h | UTC

Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum – Journal of Thrombosis and Thrombolysis

Related: Coagulation abnormalities and thrombosis in patients with COVID-19 – The Lancet AND COVID-19 and its implications for thrombosis and anticoagulation – Blood AND Prevention and Treatment of Venous Thromboembolism Associated with Coronavirus Disease 2019 Infection: A Consensus Statement before Guidelines – Thrombosis and Haemostasis AND Thrombosis and COVID-19: FAQs For Current Practice – American College of Cardiology

 


Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach

25 May, 2020 | 01:42h | UTC

Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach – Annals of Internal Medicine

 


WHO: At Least 80 million Children Under One at Risk of Diseases Such as Diphtheria, Measles and Polio as COVID-19 Disrupts Routine Vaccination Efforts

25 May, 2020 | 01:34h | UTC

At least 80 million children under one at risk of diseases such as diphtheria, measles and polio as COVID-19 disrupts routine vaccination efforts, warn Gavi, WHO and UNICEF – World Health Organization

Commentaries: WHO warns millions of children at risk as Covid-19 pandemic disrupts routine vaccinations – STAT AND Polio and Measles Could Surge After Disruption of Vaccine Programs – The New York Times

Related: Indirect Effects of the COVID-19 Pandemic on Maternal and Child Mortality in Low-income and Middle-income Countries

 


Updated CDC School Reopening Guidelines

25 May, 2020 | 01:38h | UTC

CDC School Reopening Guidelines – Centers for Disease Control and Prevention

Commentaries: Everyone Needs To Stop Freaking Out About CDC School Reopening Guidelines – Forbes AND What the CDC guidelines for reopening schools recommend, including mask wearing and closing playgrounds – Business Insider

 


CDC: The Coronavirus ‘Does Not Spread Easily’ From Contaminated Surfaces

25 May, 2020 | 01:39h | UTC

CDC: The coronavirus ‘does not spread easily’ from contaminated surfaces – Business Insider

See also: 6 feet away isn’t enough. Covid-19 risk involves other dimensions, too. – Vox AND Coronavirus Does Not Spread Easily on Surfaces, C.D.C. Says – The New York Times AND CDC Advice On Surface Spread Of COVID-19 ‘Has Not Changed,’ Agency Says – NPR

 


[Abstract Only] Randomized Trial: Haloperidol Effective for the Treatment of Headache in the Emergency Department

25 May, 2020 | 01:33h | UTC

Treatment of Headache in the Emergency Department: Haloperidol in the Acute Setting (THE-HA Study): A Randomized Clinical Trial – The Journal of Emergency Medicine

 


Cohort Study: Prognostic Factors Associated with Adverse Outcomes Among Patients with Covid-19

25 May, 2020 | 01:35h | UTC

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study – The BMJ

Related Study: Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study – The BMJ

Editorial: Covid-19 care before, during, and beyond the hospital

Commentary: Age, male sex, obesity, and underlying illness risk factors for severe COVID-19 or death – The BMJ

 


Cohort Study: Fluconazole Use in the First Trimester of Pregnancy Linked to Increased Risk of Musculoskeletal Malformations

25 May, 2020 | 01:31h | UTC

Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study – The BMJ

Commentary: Musculoskeletal Malformations Up With Fluconazole in Pregnancy – Physician’s Weekly

 


Mon May 25 – 10 Stories of The Day!

25 May, 2020 | 02:08h | UTC

 

1 – Remdesivir for the Treatment of Covid-19 — Preliminary Report – New England Journal of Medicine

Commentaries: Preliminary report on NIAID trial of remdesivir – PulmCrit AND Peer-reviewed data shows remdesivir for COVID-19 improves time to recovery – National Institutes of Health AND Covid-19 study details benefits of treatment with remdesivir, and also its limitations – STAT

 

2 – Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis – The Lancet

Commentaries: Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous? – The Lancet AND What a big new study on malaria drugs as Covid-19 treatments tells us — and what it doesn’t – STAT AND Hydroxychloroquine May Cause More Harm Than Benefit To COVID-19 Patients, Says New Lancet Study – Health Policy Watch

 

3 – Why countries should stop using anti-malarial drugs for COVID-19 – The Conversation

 

4 – Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial – The Lancet

Commentaries: First human trial of COVID-19 vaccine finds it is safe and induces rapid immune response – The Lancet AND Early Study Of Covid-19 Vaccine Developed In China Sees Mixed Results – Forbes AND Coronavirus Vaccine Shows Promising Early Results in China – The New York Times AND A Chinese biotech just published the first human data for its coronavirus vaccine candidate, supporting further trials – Business Insider AND Experts skeptical after researchers report positive vaccine results – CNN AND Two COVID-19 Vaccine Candidates Induce Immune Response In Healthy Volunteers – Health Policy Watch

 

5 – The world needs Covid-19 vaccines. It may also be overestimating their power – STAT

 

6 – SARS-CoV2 vaccines: Slow is fast – Science

 

7 – Susceptibility to and transmission of COVID-19 amongst children and adolescents compared with adults: a systematic review and meta-analysis – medRxiv

Commentaries: Children appear half as likely to catch COVID-19 as adults – London School of Hygiene & Tropical Medicine AND Expert reaction to systematic review preprint looking at susceptibility to SARS-CoV-2 infection in children and adolescents compared with adults – Science Media Centre

 

8 – Coronavirus Disease 2019 Test Results After Clinical Recovery and Hospital Discharge Among Patients in China – JAMA Network Open

Commentaries: Expert reaction to study on PCR testing results from 60 people after clinical recovery from COVID-19 – Science Media Centre AND 16% of recovered patients test positive for COVID-19 weeks after discharge: study – UPI

 

9 – SARS-CoV-2 RNA in wastewater anticipated COVID-19 occurrence in a low prevalence area – Water Research

Related: New Research Examines Wastewater to Detect Community Spread of Covid-19

 

10 –COVID-19 Updates / 25 May 2020 Edition

25 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 


COVID-19: Updates for Critical Care and Emergency Physicians

25 May, 2020 | 00:01h | UTC

Guidelines:

Podcasts:

Videos:

Selected Articles:

“This pandemic has changed the risk-benefit balance for CPR: from “there is no harm in trying” to “there is little benefit to the patient, and potentially significant harm to staff.””

News & Perspectives:

COVID-19 Critical Care: This page will be updated as often as necessary and will be fixed in the right column on our homepage.

 


COVID-19: Updates for Anesthesiologists

25 May, 2020 | 00:01h | UTC

Guidelines:

Articles:

COVID-19 Anesthesiology: This page will be updated as often as necessary and will be fixed in the right column on our homepage.

 


COVID-19: Updates for Pediatricians

25 May, 2020 | 00:01h | UTC

Podcasts:

Guidelines & Reports:

Selected Articles:

News & Perspectives:

COVID-19 Pediatrics: This page will be updated as often as necessary and will be fixed in the right column on our homepage.

 


COVID-19: Updates for Gastroenterologists

25 May, 2020 | 00:01h | UTC

Guidelines:

Selected Articles:

COVID-19 Gastroenterology: This page will be updated as often as necessary and will be fixed in the right column on our homepage.

 


COVID-19: Updates for Oncologists & Hematologists

25 May, 2020 | 00:01h | UTC

Oncology Guidelines

Oncology Articles

Hematologic Guidelines

Hematology Articles

Guidelines:

Articles:

News & Perspectives:

COVID-19 Hemato-Oncology: This page will be updated as often as necessary and will be fixed in the right column on our homepage.

 


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