Daily Archives: April 30, 2020

Randomized Trial: Remdesivir Not Beneficial for Adults with Severe COVID-19

30 Apr, 2020 | 04:31h | UTC

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial – The Lancet

Commentaries: First randomized trial of remdesivir suggests antiviral drug is not associated with significant clinical benefits, more research needed – The Lancet AND Expert reaction to trial of remdesivir in adults – Science Media Centre

See also: [Not Published Yet] NIH Study Shows Remdesivir Accelerates Recovery from Advanced COVID-19

 

Related Commentary on Twitter

With all the hype about Remdesivir today @TheLancet has decided to lift the embargo and release this placebo-controlled multicenter study done in China that showed no benefit https://t.co/ZdmKfnWLyw

— Carlos del Rio (@CarlosdelRio7) April 29, 2020

 

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Pooling of Samples for Testing for SARS-CoV-2 in Asymptomatic People

30 Apr, 2020 | 04:25h | UTC

Pooling of samples for testing for SARS-CoV-2 in asymptomatic people – The Lancet Infectious Diseases AND Commentary: Virologists show that sample pooling can massively increase coronavirus testing capacity – Saarland University

Related Preprint Study: Smart Pooled sample Testing for COVID-19: A Possible Solution for Sparsity of Test Kits – medRxiv AND Commentary: ‘Smart sample pooling’ for COVID-19 could solve test kit shortage problem – News Medical

 

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[Not Published Yet] NIH Study Shows Remdesivir Accelerates Recovery from Advanced COVID-19

30 Apr, 2020 | 04:28h | UTC

NIH clinical trial shows Remdesivir accelerates recovery from advanced COVID-19 – National Institutes of Health

Commentaries: Hopes rise on coronavirus drug remdesivir – Nature AND The COVID-19 research news rollercoaster is running again: STAT News + Gilead’s remdesivir – HealthNews Review

See also: Randomized Trial: Remdesivir Not Beneficial for Adults with Severe COVID-19

 

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Audio Interview: Loosening Covid-19 Restrictions

30 Apr, 2020 | 04:17h | UTC

Audio Interview: Loosening Covid-19 Restrictions – New England Journal of Medicine

 

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Men with COVID-19 Twice More Likely to Die than Women

30 Apr, 2020 | 04:21h | UTC

Gender Differences in Patients With COVID-19: Focus on Severity and Mortality – Frontiers in Public Health

News Release: COVID-19 study shows that men have over double the death rate of women – Frontiers

 

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Perspective: Covid-19 — A Reminder to Reason

30 Apr, 2020 | 04:15h | UTC

Covid-19 — A Reminder to Reason – New England Journal of Medicine

 

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Out-of-Hospital Cardiac Arrest during the Covid-19 Outbreak in Italy

30 Apr, 2020 | 04:19h | UTC

Out-of-Hospital Cardiac Arrest during the Covid-19 Outbreak in Italy – New England Journal of Medicine

 

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COVID-19 and Its Implications for Thrombosis and Anticoagulation

30 Apr, 2020 | 04:13h | UTC

COVID-19 and its implications for thrombosis and anticoagulation – Blood

 

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Science Has an Ugly, Complicated Dark Side. And the Coronavirus Is Bringing It Out

30 Apr, 2020 | 04:10h | UTC

Science Has an Ugly, Complicated Dark Side. And the Coronavirus Is Bringing It Out – Mother Jones

 

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What Is the Infection-Fatality Rate of COVID-19?

30 Apr, 2020 | 04:04h | UTC

What Is the Infection-Fatality Rate Of COVID-19? – Medium

 

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Randomized Trial: Hypofractionated Breast Radiotherapy for 1 Week Noninferior to 3 weeks

30 Apr, 2020 | 04:02h | UTC

Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial – The Lancet

Commentaries: 1-week hypofractionated adjuvant whole-breast radiotherapy: towards a new standard? – The Lancet AND One-week course of radiotherapy could benefit women with early stage breast cancer, study finds – Institute of Cancer Research

 

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General Guidelines in the Management of an Obstetrical Patient on the Labor and Delivery Unit during the COVID-19 Pandemic

30 Apr, 2020 | 04:07h | UTC

General Guidelines in the Management of an Obstetrical Patient on the Labor and Delivery Unit during the COVID-19 Pandemic – American Journal of Perinatology

 

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[Abstract Only] Feasibility of Blood Testing Combined with PET-CT to Screen for Cancer and Guide Intervention

30 Apr, 2020 | 04:00h | UTC

Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention – Science (link to abstract – $ for full-text)

Commentaries: DNA blood test spots cancers in seemingly cancer-free women, but also produces false alarms – Science AND First study of multicancer blood test to screen for cancer guide intervention – Johns Hopkins Medicine

 

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USPSTF Statement: Primary Care Interventions for Prevention and Cessation of Tobacco Use in Children and Adolescents

30 Apr, 2020 | 03:48h | UTC

Primary Care Interventions for Prevention and Cessation of Tobacco Use in Children and Adolescents: US Preventive Services Task Force Recommendation Statement – JAMA

Editorial: Recommendations From the USPSTF for Prevention and Cessation of Tobacco Use in Children and Adolescents (free for a limited period)

Author Interview: USPSTF Recommendation: Tobacco Use Prevention and Cessation in Children and Adolescents

Commentary: USPSTF: Clinicians Should Counsel Kids to Not Start Smoking – NEJM Journal Watch

 

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Clinical Guidelines for the Management of Eosinophilic Esophagitis

30 Apr, 2020 | 03:55h | UTC

AGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters Clinical Guidelines for the Management of Eosinophilic Esophagitis – Gastroenterology

Commentary: New guideline provides evidence-based recommendations for clinical management of EoE – American Gastroenterology Association

 

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Consensus Statement on Fundamental Concepts in Perioperative Fluid Management

30 Apr, 2020 | 03:51h | UTC

Perioperative Quality Initiative (POQI) consensus statement on fundamental concepts in perioperative fluid management: fluid responsiveness and venous capacitance – Perioperative Medicine

 

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Systematic Review: Treating Disseminated Histoplasmosis in People Living with HIV

30 Apr, 2020 | 03:41h | UTC

Treating progressive disseminated histoplasmosis in people living with HIV – Cochrane Library

Summary: How best to treat progressive disseminated histoplasmosis in people with HIV – Cochrane Library

 

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[Abstract Only] Randomized Trial: Olaparib for Metastatic Castration-Resistant Prostate Cancer

30 Apr, 2020 | 03:38h | UTC

Olaparib for Metastatic Castration-Resistant Prostate Cancer – New England Journal of Medicine

 

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Advances in Regenerative Medicine for Otolaryngology/Head and Neck Surgery

30 Apr, 2020 | 03:45h | UTC

Advances in regenerative medicine for otolaryngology/head and neck surgery – The BMJ

 

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Thu April 30 – 10 Stories of The Day!

30 Apr, 2020 | 04:34h | UTC

 

1 – Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial – The Lancet

Commentaries: First randomized trial of remdesivir suggests antiviral drug is not associated with significant clinical benefits, more research needed – The Lancet AND Expert reaction to trial of remdesivir in adults – Science Media Centre

 

2 – NIH clinical trial shows Remdesivir accelerates recovery from advanced COVID-19 – National Institutes of Health

Commentaries: Hopes rise on coronavirus drug remdesivir – Nature AND The COVID-19 research news rollercoaster is running again: STAT News + Gilead’s remdesivir – HealthNews Review

 

3 – Pooling of samples for testing for SARS-CoV-2 in asymptomatic people – The Lancet Infectious Diseases AND Commentary: Virologists show that sample pooling can massively increase coronavirus testing capacity – Saarland University

Related Preprint Study: Smart Pooled sample Testing for COVID-19: A Possible Solution for Sparsity of Test Kits – medRxiv AND Commentary: ‘Smart sample pooling’ for COVID-19 could solve test kit shortage problem – News Medical

 

4 – Gender Differences in Patients With COVID-19: Focus on Severity and Mortality – Frontiers in Public Health

News Release: COVID-19 study shows that men have over double the death rate of women – Frontiers

 

5 – Out-of-Hospital Cardiac Arrest during the Covid-19 Outbreak in Italy – New England Journal of Medicine

 

6 – Audio Interview: Loosening Covid-19 Restrictions – New England Journal of Medicine

 

7 – Covid-19 — A Reminder to Reason – New England Journal of Medicine

 

8 – COVID-19 and its implications for thrombosis and anticoagulation – Blood

 

9 – Science Has an Ugly, Complicated Dark Side. And the Coronavirus Is Bringing It Out – Mother Jones

 

10 – Coronavirus Disease (COVID-19) Updates / 30 April 2020 Edition

30 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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