Daily Archives: January 16, 2020
Thu January 16 – 10 Stories of The Day!
16 Jan, 2020 | 09:13h | UTC
1 – Four major results to be presented at #CCR20 – PEPTIC, 65, & VITAMINS trials, plus the IHME Sepsis Study – More Info on the Critical Care Reviews Website
Commentary: Clinical trial results in critical care medicine to be unveiled at leading UK conference – EurekAlert (free)
– Thursday January 16th (09:00 to 10:30) – 65 Results Presentation Session – https://vimeo.com/383967830
See Study Protocol: Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Protocol for the 65 randomised clinical trial – Journal of the Intensive Care Society (free)
– Thursday January 16th (16:35 to 17:40 – IHME Sepsis Study Results – https://vimeo.com/383968757
– Friday January 17th (09:00 to 10:30) – PEPTIC Trial Results Session – https://vimeo.com/383968980
See Study Protocol: A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): study protocol. – Critical Care and Resuscitation (free PDF)
– Friday January 17th (11:00 to 12:30) – VITAMINS Trial Results – https://vimeo.com/383969217
See Study Protocol: Vitamin C, Hydrocortisone and Thiamine in Patients with Septic Shock (VITAMINS) trial: study protocol and statistical analysis plan – Critical Care and Resuscitation (free PDF)
2 – Report Summary: What researchers think about the culture they work in – Wellcome Trust (free)
Full Report: What researchers think about the culture they work in – Wellcome Trust (free PDF)
Commentary: Researchers facing ‘shocking’ levels of stress, survey reveals – The Guardian (free)
3 – A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants – New England Journal of Medicine (link to abstract – $ for full-text)
4 – Effect of a Behavioral Intervention to Increase Vegetable Consumption on Cancer Progression Among Men With Early-Stage Prostate Cancer: The MEAL Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: Eating more vegetables provides no extra protection for men with prostate cancer – News Medical (free) AND Does Increased Vegetable Consumption Affect Prostate Cancer Progression? – MedicalResearch.com (free)
5 – Patient-Reported Outcomes Through 5 Years for Active Surveillance, Surgery, Brachytherapy, or External Beam Radiation With or Without Androgen Deprivation Therapy for Localized Prostate Cancer – JAMA (free for a limited period)
Related Study: Ten-year Outcomes in Men with Localized Prostate Cancer from the ProtecT Randomized Controlled Trial According to Treatment Received (free)
Commentaries: Prostatectomy-associated urinary incontinence disparities persist at 5 years – MedwireNews (free) AND Prostate Cancer Treatment Side Effects Worse With Prostatectomy – Renals & Urology News (free)
Author Interview: Interventions and Operations 5 Years After Bariatric Surgery (free)
Commentaries: Bariatric Surgery Is Safe and It Works – JAMA Surgery (free for a limited period) AND Procedures And Hospitalizations Common After Bariatric Procedures – MedicalResearch.com (free) AND More Interventions Follow Gastric Bypass than Gastric Sleeve, Large Study Shows – Health Sciences at the University of Pittsburgh (free)
Related Study: Cohort Study: Risk of Operative and Nonoperative Interventions After Roux-en-Y Gastric Bypass vs. Vertical Sleeve Gastrectomy (free)
7 – An integrated perfusion machine preserves injured human livers for 1 week – Nature Biotechnology (free for a limited period)
Commentaries: Machine keeps human livers alive for one week outside of the body – University of Zurich (free) AND Machine Could Expand Pool of Livers for Donation – HealthDay News (free)
Commentary: Strong Case for Outpatient Fracture Surgery – Orthobuzz (free)
Four Major Studies in Critical Care to be Presented at #CCR20 – PEPTIC, 65, & VITAMINS trials, plus the IHME Sepsis Study
16 Jan, 2020 | 08:59h | UTCFour major results to be presented at #CCR20 – PEPTIC, 65, & VITAMINS trials, plus the IHME Sepsis Study – More Info on the Critical Care Reviews Website
Commentary: Clinical trial results in critical care medicine to be unveiled at leading UK conference – EurekAlert (free)
1 – Thursday January 16th (09:00 to 10:30) – 65 Results Presentation Session – https://vimeo.com/383967830
See Study Protocol: Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Protocol for the 65 randomised clinical trial – Journal of the Intensive Care Society (free)
2 – Thursday January 16th (16:35 to 17:40 – IHME Sepsis Study Results – https://vimeo.com/383968757
3 – Friday January 17th (09:00 to 10:30) – PEPTIC Trial Results Session – https://vimeo.com/383968980
See Study Protocol: A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): study protocol. – Critical Care and Resuscitation (free PDF)
4 – Friday January 17th (11:00 to 12:30) – VITAMINS Trial Results – https://vimeo.com/383969217
Report: What Researchers Think About the Culture they Work In
16 Jan, 2020 | 08:57h | UTCReport Summary: What researchers think about the culture they work in – Wellcome Trust (free)
Full Report: What researchers think about the culture they work in – Wellcome Trust (free PDF)
Commentary: Researchers facing ‘shocking’ levels of stress, survey reveals – The Guardian (free)
Observational Study: Patient-Reported Outcomes Through 5 Years for Active Surveillance, Surgery, Brachytherapy, or External Beam Radiation for Localized Prostate Cancer
16 Jan, 2020 | 08:53h | UTCPatient-Reported Outcomes Through 5 Years for Active Surveillance, Surgery, Brachytherapy, or External Beam Radiation With or Without Androgen Deprivation Therapy for Localized Prostate Cancer – JAMA (free for a limited period)
Related Study: Ten-year Outcomes in Men with Localized Prostate Cancer from the ProtecT Randomized Controlled Trial According to Treatment Received (free)
Commentaries: Prostatectomy-associated urinary incontinence disparities persist at 5 years – MedwireNews (free) AND Prostate Cancer Treatment Side Effects Worse With Prostatectomy – Renals & Urology News (free)
An Integrated Perfusion Machine Preserves Injured Human Livers for 1 Week
16 Jan, 2020 | 04:08h | UTCAn integrated perfusion machine preserves injured human livers for 1 week – Nature Biotechnology (free for a limited period)
Commentaries: Machine keeps human livers alive for one week outside of the body – University of Zurich (free) AND Machine Could Expand Pool of Livers for Donation – HealthDay News (free)
[Abstract Only] Randomized Trial: Erythropoietin Not Beneficial for Neuroprotection in Preterm Infants
16 Jan, 2020 | 08:56h | UTCA Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants – New England Journal of Medicine (link to abstract – $ for full-text)
Randomized Trial: Behavioral Intervention to Increase Vegetable Consumption Does Not Affect Cancer Progression Among Men with Early-Stage Prostate Cancer
16 Jan, 2020 | 08:55h | UTCEffect of a Behavioral Intervention to Increase Vegetable Consumption on Cancer Progression Among Men With Early-Stage Prostate Cancer: The MEAL Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: Eating more vegetables provides no extra protection for men with prostate cancer – News Medical (free) AND Does Increased Vegetable Consumption Affect Prostate Cancer Progression? – MedicalResearch.com (free)
Among men with early-stage #prostatecancer managed with active surveillance, a behavioral intervention that increased vegetable consumption did not reduce risk of prostate cancer progression https://t.co/lUMNmHL6qG
— JAMA (@JAMA_current) January 15, 2020
Cohort Study: Interventions and Operations 5 Years After Bariatric Surgery
16 Jan, 2020 | 08:51h | UTCAuthor Interview: Interventions and Operations 5 Years After Bariatric Surgery (free)
Commentaries: Bariatric Surgery Is Safe and It Works – JAMA Surgery (free for a limited period) AND Procedures And Hospitalizations Common After Bariatric Procedures – MedicalResearch.com (free) AND More Interventions Follow Gastric Bypass than Gastric Sleeve, Large Study Shows – Health Sciences at the University of Pittsburgh (free)
Related Study: Cohort Study: Risk of Operative and Nonoperative Interventions After Roux-en-Y Gastric Bypass vs. Vertical Sleeve Gastrectomy (free)
A Network Meta‐analysis of the Effects of Psychotherapies, Pharmacotherapies and their Combination in the Treatment of Adult Depression
16 Jan, 2020 | 04:04h | UTC
Study: The Development of a Standardized Pathway for Outpatient Ambulatory Fracture Surgery
16 Jan, 2020 | 03:57h | UTCCommentary: Strong Case for Outpatient Fracture Surgery – Orthobuzz (free)
Review: Management of Patients Undergoing Same-day Discharge Primary Total Kip and knee Arthroplasty
16 Jan, 2020 | 04:02h | UTC
Incidence of Infectious Complications Following Cochlear Implantation in Children and Adults
16 Jan, 2020 | 03:27h | UTCIncidence of Infectious Complications Following Cochlear Implantation in Children and Adults – JAMA (free for a limited period)
Viewpoint – Treatment Decisions for a Future Self: Ethical Obligations to Guide Truly Informed Choices
16 Jan, 2020 | 03:34h | UTCTreatment Decisions for a Future Self: Ethical Obligations to Guide Truly Informed Choices – JAMA (free for a limited period)
Author Interview: Treatment Decisions for a Future Self (free)
Randomized Trial: Twice-daily vs. Alternate-day Oral Iron Therapy in the Treatment of Iron-deficiency Anemia
16 Jan, 2020 | 03:23h | UTC
Non-sleepy Obstructive Sleep Apnea: To Treat or Not to Treat?
16 Jan, 2020 | 02:57h | UTCNon-sleepy obstructive sleep apnoea: to treat or not to treat? – European Respiratory Review (free)
Related: Pro/Con Debate: Should Asymptomatic Patients with Moderate-to-severe OSA be Treated? (free) AND Obstructive Sleep Apnea in Cardiovascular Disease: A Review of the Literature and Proposed Multidisciplinary Clinical Management Strategy (free reviews) AND Positive airway pressure doesn’t reduce cardiovascular events and death in adults with sleep apnea (link to abstract and commentaries)
[Abstract Only] Study: Diabetes in Adolescents Linked to Greatly Increased Risk of Suicide Behavior
16 Jan, 2020 | 03:20h | UTCRisk of Psychiatric Disorders and Suicide Attempts in Emerging Adults With Diabetes – Diabetes Care (link to abstract – $ for full-text)
Commentary: Suicide rates sharply higher than average in teens, young adults with diabetes – Reuters (free)
Systematic Review: Toric Intraocular Lenses vs. Limbal Relaxing Incisions for Astigmatism in Cataract Surgery
16 Jan, 2020 | 02:47h | UTCToric intraocular lens versus limbal relaxing incisions for corneal astigmatism after phacoemulsification – Cochrane Library (free)
Summary: Toric intraocular lenses versus limbal relaxing incisions for astigmatism in cataract surgery – Cochrane Library (free)
Oral Appliance Therapy for Obstructive Sleep Apnea: State of the Art
16 Jan, 2020 | 03:03h | UTCOral Appliance Therapy for Obstructive Sleep Apnoea: State of the Art – Journal of Clinical Medicine (free)
Potentially Inappropriate Prescribing in Dementia: A State-of-the-art Review
16 Jan, 2020 | 02:45h | UTCPotentially inappropriate prescribing in dementia: a state-of-the-art review since 2007 – BMJ Open (free)
Systematic Review: Interventions to Slow Progression of Myopia in Children
16 Jan, 2020 | 02:54h | UTCInterventions to slow progression of myopia in children – Cochrane Library (free)
Summary: Interventions to slow progression of nearsightedness in children – Cochrane Library (free)
The use of Antidepressants in Oncology: A Review and Practical Tips for Oncologists
16 Jan, 2020 | 02:39h | UTC
NCCN Guideline: Pediatric Acute Lymphoblastic Leukemia
16 Jan, 2020 | 02:42h | UTC
Position Statement on the Role of Percutaneous Ablation in Renal Cell Carcinoma
16 Jan, 2020 | 02:36h | UTC
[Abstract Only] Cohort Study: Colorectal Cancer in Ulcerative Colitis
16 Jan, 2020 | 02:34h | UTCColorectal cancer in ulcerative colitis: a Scandinavian population-based cohort study – The Lancet (link to abstract – $ for full-text)
Commentary: Association Between Colorectal Cancer and Ulcerative Colitis – The ASCO Post (free)
[Abstract Only] Randomized Trial: Ixekizumab for Patients with Non-radiographic Axial Spondyloarthritis
16 Jan, 2020 | 02:29h | UTCIxekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary: #VisualAbstract: Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X) – 2 Minute Medicine (free)
In this week's issue—Ixekizumab was superior to placebo for improving signs and symptoms in patients with non-radiographic axial spondyloarthritis at weeks 16 and 52: COAST-X, a randomised, placebo-controlled trial https://t.co/XuKDKGJns0 pic.twitter.com/bbuOReLCu2
— The Lancet (@TheLancet) January 8, 2020