Daily Archives: August 31, 2018
Randomized Trial: Partial Oral vs. Intravenous Antibiotic Treatment of Endocarditis
31 Aug, 2018 | 03:11h | UTCPartial Oral versus Intravenous Antibiotic Treatment of Endocarditis – New England Journal of Medicine (free for a limited period)
Commentaries: Partial Oral Treatment of Endocarditis – POET – American College of Cardiology (free) AND New treatment can halve hospital stays for some patients with heart infection – ESC Press Releases (free)
ESC/EACTS Guidelines on Myocardial Revascularization
31 Aug, 2018 | 03:09h | UTC2018 ESC/EACTS Guidelines on myocardial revascularization – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)
ESC/ESH Guidelines for the Management of Arterial Hypertension
31 Aug, 2018 | 03:10h | UTC2018 ESC/ESH Guidelines for the management of arterial hypertension – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)
Fourth Universal Definition of Myocardial Infarction
31 Aug, 2018 | 03:09h | UTCFourth universal definition of myocardial infarction (2018) – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)
Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes
31 Aug, 2018 | 03:07h | UTCEffects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus – New England Journal of Medicine (free for a limited period)
Commentaries: Bleeds and benefit with aspirin balanced in patients with diabetes and no effect on cancer – ESC Press Releases (free) AND ASCEND: Aspirin Doesn’t Look Good for Primary CV Prevention in Diabetic Patients – TCTMD (free)
Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease
31 Aug, 2018 | 03:06h | UTCUse of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Aspirin Fails to Prevent CV Events in People at ‘Moderate’ Risk of Disease: ARRIVE – TCTMD (free) AND ARRIVE: New Findings Contribute to Growing Body of Evidence Surrounding Aspirin Use – American College of Cardiology (free) AND Daily Aspirin Fails to Lower CV Risk in Long-term, Primary Prevention ARRIVE Trial – Medscape (free registration required) AND Jury still out on aspirin a day to prevent heart attack and stroke – ESC Press Releases (free)
Position Statement: Recommendations for Participation in Competitive Sports of Athletes with Arterial Hypertension
31 Aug, 2018 | 03:03h | UTC
Randomized Trial: Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery
31 Aug, 2018 | 03:05h | UTCSix-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery – New England Journal of Medicine (free for a limited period)
“In moderate-to-high-risk patients undergoing cardiac surgery, six-month outcomes show that a restrictive red-cell transfusion strategy is noninferior to a liberal strategy” (via @NEJM see Tweet with Visual Abstract)
ESC Guidelines for the Management of Cardiovascular Diseases During Pregnancy
31 Aug, 2018 | 03:02h | UTC2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)
Meta-Analysis: Effectiveness of Interventions for Managing Multiple High-Burden Chronic Diseases in Older Adults
31 Aug, 2018 | 03:01h | UTCCommentaries: Care coordination improves health of older patients with multiple chronic diseases – CMAJ, via EurekAlert (free) AND Seniors healthier when medical care is coordinated – Reuters (free)
Related: Ten Recommendations: Designing a High-Performing Health Care System for Patients with Complex Needs (free Guidance and related perspectives) AND Multimorbidity: A Priority for Global Health Research (free research and commentaries)
Clinical Report: Implications of Marijuana Use During Pregnancy and Breastfeeding
31 Aug, 2018 | 02:57h | UTCNews Release: Counsel against marijuana use in pregnancy, breastfeeding – American Academy of Pediatrics (free)
Related Article: Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk – Pediatrics (free)
Commentaries: A Modern Conundrum for the Pediatrician: The Safety of Breast Milk and the Cannabis-Using Mother – Pediatrics (free) AND Marijuana study finds THC in breast milk up to 6 days after mom’s use – CNN (free) AND Pediatricians Put It Bluntly: Motherhood And Marijuana Don’t Mix – Kaiser Health News (free) AND Clinical report provides guidance on marijuana use in pregnancy and lactation – 2 Minute Medicine (free)
A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure with Preserved Ejection Fraction
31 Aug, 2018 | 03:00h | UTCA Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction – Circulation (free) (via @CircAHA see Tweet with Infographic)
Editorial: H2FPEF Score: At Last, a Properly Validated Diagnostic Algorithm for Heart Failure With Preserved Ejection Fraction (free)
Randomized Trial: Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus
31 Aug, 2018 | 02:58h | UTCEffects of n−3 Fatty Acid Supplements in Diabetes Mellitus – New England Journal of Medicine (free for a limited period)
Commentaries: Fish oils do not prevent heart attack or strokes in people with diabetes – ESC News Releases (free) AND Omega-3 Fatty Acids Fail to Reduce CVD Events in Diabetic Patients: ASCEND – TCTMD (free)
Related Cochrane Review: Omega-3 fatty Acids for the Prevention of Cardiovascular Disease (link to abstract and commentaries)
Related Meta-Analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk (free study and commentary)
Study: Evaluating the Replicability of Social Science Experiments
31 Aug, 2018 | 02:50h | UTCEvaluating the replicability of social science experiments in Nature and Science between 2010 and 2015 – Nature Human Behavior (free for a limited period)
Commentaries: More social science studies just failed to replicate. Here’s why this is good – VOX (free) AND High-profile journals put to reproducibility test – Nature News (free) AND ‘Replication crisis’ spurs reforms in how science studies are done – ScienceNews (free) AND The Science Behind Social Science Gets Shaken Up—Again – WIRED (Free) AND In Psychology And Other Social Sciences, Many Studies Fail The Reproducibility Test – NPR (free)
“We replicated 21 social science experiments in Science or Nature. We succeeded with 13. Replication effect sizes were half of originals.” (via @BrianNosek see Tweet)
Guideline Synopsis: Diagnosis and Treatment of Clostridium difficile Infection
31 Aug, 2018 | 02:51h | UTCDiagnosis and Treatment of Clostridium difficile Infection – JAMA (free for a limited period) (via @ABsteward and @Abraham_RMI)
Original Guideline: Clinical Practice Guidelines for Clostridium difficileInfection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) – Clinical Infectious Diseases (free)
CHEST Guideline: Antithrombotic Therapy for Atrial Fibrillation
31 Aug, 2018 | 02:56h | UTCAntithrombotic Therapy for Atrial Fibrillation: CHEST Guideline and Expert Panel Report (free PDF)
News Release: The American College of Chest Physicians updates their antithrombotic therapy guidelines for patients with atrial fibrillation (free)
Randomized Trial: High-Sensitivity Troponin in the Evaluation of Suspected Acute Coronary Syndrome
31 Aug, 2018 | 02:49h | UTCCommentaries: Diagnosing myocardial infarction: a highly sensitive issue – The Lancet (free) AND Hs-TnI in Suspected ACS: High-STEACS Trial – American College of Cardiology (free) AND Is High Sensitivity Troponin Too Sensitive? – NEJM Journal Watch (free)
“Introduction of a high-sensitivity cardiac troponin I assay reclassified 1 in 6 patients with previously undetected myocardial necrosis, but did not lead to improved clinical outcomes in this large randomised trial” (via @chapdoc1 see Tweet)
“Very important study. What’s weird is that the “better” (more sensitive) troponin assays get, the less helpful the test becomes at the bedside. Look for a coming tsunami of iatrogenesis from overzealous evaluation of troponin bumps.” (via @drjohnm see Tweet)
Guideline: Management of Hypertensive Emergencies
31 Aug, 2018 | 02:45h | UTCESC Council on hypertension position document on the management of hypertensive emergencies – European Heart Journal – Cardiovascular Pharmacotherapy (free) (@Abraham_RMI)
“Patients that lack acute hypertension-mediated end organ damage to the heart, retina, brain, kidneys, or large arteries do not have a hypertensive emergency and can be treated with oral BP-lowering agents and usually discharged after a brief period of observation.”
Guideline: Management of Malignant Pleural Effusions
31 Aug, 2018 | 02:48h | UTCERS/EACTS statement on the management of malignant pleural effusions – European Respiratory Journal (free)
Evidence Review: Optimal Blood Pressure Target in Diabetic and Nondiabetic Hypertensive Patients
31 Aug, 2018 | 02:44h | UTCSee counterpoint suggesting lower BP targets: Sprinting Toward the Optimal Blood Pressure Target for Hypertensive Patients – Circulation Research (free)
“We have reviewed the randomized trial evidence in favor of a target blood pressure (BP) around 130/80 mm Hg in hypertensive patients with and without diabetes mellitus”
Study: Vitamin D Not Linked to Fracture Risk
31 Aug, 2018 | 02:43h | UTCCommentaries: Vitamin D: a pseudo-vitamin for a pseudo-disease – The Conversation (free) AND Fracture risk not linked to low vitamin D or calcium levels – OnMedica (free)
Related: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It (free commentaries and NICE Guideline)
Meta-Analysis: Environmental Toxic Metal Contaminants and Risk of Cardiovascular Disease
31 Aug, 2018 | 02:42h | UTCEditorial: Environmental metals and cardiovascular disease (free)
Commentary: Experts warn of cardiovascular risk from heavy metal pollution – University of Cambridge (free)
“Since metals are associated with cardiovascular disease even at relatively low levels of exposure, population wide strategies to minimize exposure can further contribute to overall cardiovascular prevention efforts” (from @bmj_latest see Tweet)
Study: Bacterial Factors That Predict Relapse after Tuberculosis Therapy
31 Aug, 2018 | 02:41h | UTCBacterial Factors That Predict Relapse after Tuberculosis Therapy – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Bacterial Factors That Predict Relapse after Antituberculosis Therapy – NEJM Resident 360 (free) AND MICs of Isoniazid, Rifampin May Predict Tuberculosis Relapse – Drugs.com (free) AND Variation in bacterial drug susceptibility tied to TB relapse risk – CHEST Physician (free)
Clinical Decisions: Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome
31 Aug, 2018 | 02:39h | UTC
Perspective: Revisiting the Timetable of Tuberculosis
31 Aug, 2018 | 02:40h | UTCRevisiting the timetable of tuberculosis – The BMJ (free)
Related: Soumya Swaminathan: TB programmes should focus on people with highest risk of progression to disease – The BMJ Opinion (free)