Daily Archives: May 18, 2018
WHO Report: A Strategic Response to Noncommunicable Diseases
18 May, 2018 | 02:44h | UTCNews Release: Investing in noncommunicable disease control generates major financial and health gains – World Health Organization (free)
“For every US$1 invested in each policy area, the following returns have been documented:
US$12.82 from promoting healthy diets
US$9.13 from reducing the harmful use of alcohol
US$7.43 from lower tobacco use
US$3.29 from providing drug therapy for cardiovascular disease
US$2.80 from increasing physical activity
US$2.74 from managing cancer”
Randomized Trial: Shortening Adjuvant Trastuzumab to 6 Months in Selected Patients with Breast Cancer
18 May, 2018 | 02:44h | UTCASCO 2018: Shortening Adjuvant Trastuzumab to 6 Months in Patients With HER2-Positive Early Breast Cancer Is Effective and Reduces Cardiac Toxicities – The ASCO Post (free)
Commentaries: Test of Herceptin Finds Briefer Treatment Can Work, With Fewer Side Effects – NPR (free) AND Shorter drug treatment OK for many breast cancer patients – Associated Press (free) AND For Women With Early Breast Cancer, Herceptin Treatment Can Be Much Shorter – The New York Times (10 articles per month are free)
““For women with early-stage breast cancer who needed the drug Herceptin, 6 months of treatment were as good as 12, a major study found. Less risk of side effects, less cost, less time “being a patient.”” (via @NYTHealth see Tweet)
Randomized Trial: Ibuprofen Alone For Uncomplicated UTI
18 May, 2018 | 02:41h | UTCCommentary: Ibuprofen alone not an option for simple UTIs, study finds – CIDRAP (free) AND Randomized trial finds ibuprofen not a safe alternative to antibiotics for UTIs – PLOS, via ScienceDaily (free)
Related Research: Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial- The BMJ (free)
Report: Global Burden of Multiple Myeloma
18 May, 2018 | 02:42h | UTC“Global incident cases of multiple myeloma more than doubled from 1990-2016 w/incident cases increasing by 126%. The largest increase was in middle-SDI countries, particularly E. Asia with a 262% increase in incidence cases”. (via @IHME_UW see Tweet)
WHO Manual: Key Facts About Major Deadly Diseases
18 May, 2018 | 02:42h | UTCManaging epidemics: Key facts about major deadly diseases – World Health Organization (free)
“Managing epidemics. This @WHO manual provides concise, up-to-date knowledge on 15 infectious diseases that have the potential to become international threats, and tips on how to respond to each of them”. (via @Onisillos and @claireekt see Tweet)
Cohort Study: Five-Year Risk of Stroke after TIA or Minor Ischemic Stroke
18 May, 2018 | 02:39h | UTCFive-Year Risk of Stroke after TIA or Minor Ischemic Stroke – New England Journal of Medicine (free)
Commentary: Elevated Stroke Risk Continues for 5 Years After TIA – NEJM Physician’s First Watch (free) AND Five Years after TIA or Minor Stroke, Second-Event Risk Persists – MedPage Today (free)
Guideline: Management of Mantle Cell Lymphoma
18 May, 2018 | 02:40h | UTCGuideline for the management of mantle cell lymphoma – British Journal of Haematology (free)
Randomized Controlled Trial: Tranexamic Acid for Hyperacute Primary Intracerebral Hemorrhage
18 May, 2018 | 02:36h | UTCEditorial: Haemostatic treatment for intracerebral haemorrhage (free)
Commentaries: Study: Drug to treat bleeding may reduce stroke deaths – UPI (free) AND Drug to treat bleeding may benefit some stroke patients, study finds – University of Nottingham, via EurekAlert (free)
Randomized Trial: MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset
18 May, 2018 | 02:37h | UTCMRI-Guided Thrombolysis for Stroke with Unknown Time of Onset – New England Journal of Medicine (free)
Editorial: MRI-Guided Intravenous Alteplase for Stroke — Still Stuck in Time (free)
Commentary: New treatment option for ‘wake-up’ stroke patients – University of Glasgow, via MedicalXpress (free)
Randomized Trial: Rivaroxaban Not Effective for Stroke Prevention after Embolic Stroke of Undetermined Source
18 May, 2018 | 02:38h | UTCCommentaries: NAVIGATE ESUS: Rivaroxaban Fails to Prevent More Recurrent Cryptogenic Strokes Than Aspirin – TCTMD (free) AND Rivaroxaban Not Superior to Aspirin for Patients with Embolic Stroke of Unknown Source – NEJM Physician’s First Watch (free)
Randomized Trial: Dual Antiplatelet Therapy in Acute Ischemic Stroke and High-Risk TIA
18 May, 2018 | 02:36h | UTCClopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA – New England Journal of Medicine (free)
Editorial: Antiplatelet Therapy after Ischemic Stroke or TIA (free)
Commentary: Dual Antiplatelet Therapy or Aspirin Alone After TIA or Minor Stroke? – NEJM Physician’s First Watch (free)
Consensus: Adverse Effects of Statin Therapy
18 May, 2018 | 02:34h | UTCCommentary: EAS Consensus Document Examines Safety of Statins Beyond Muscle Symptoms – TCTMD (free)
Clinical Guideline: Pharmacotherapy for Neuropathic Pain
18 May, 2018 | 02:33h | UTC
Guideline Summary: Cardio-Onco-Hematology in Clinical Practice
18 May, 2018 | 02:35h | UTCOriginal Guideline: Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations – Revista Espanola de Cardiologia (free)
Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)
Opinion: The Ten Pitfalls of Lactate Clearance in Sepsis
18 May, 2018 | 02:33h | UTCThe ten pitfalls of lactate clearance in sepsis – Intensive Care Medicine (free)
Source: Critical Care Reviews Newsletter
Systematic Review: Psychological Therapies for Treatment-resistant Depression in Adults
18 May, 2018 | 02:31h | UTCPsychological therapies for treatment-resistant depression in adults – Cochrane Library (free)
Summary: Are psychological therapies effective in treating depression that did not get better with previous treatment? – Cochrane Library (free)
Cohort Study: Chemotherapy-Induced Neuropathy in Survivors of Childhood Cancer
18 May, 2018 | 02:32h | UTCChemotherapy-Induced Peripheral Neuropathy in Long-term Survivors of Childhood Cancer: Clinical, Neurophysiological, Functional, and Patient-Reported Outcomes – JAMA Neurology (free for a limited period)
Commentaries: Peripheral Neuropathy Common in Childhood Cancer Survivors – MPR (free) AND Chemo-Induced Neuropathy Common after Childhood Cancer – MedPage Today (free registration required)
Meta-Analysis: Cancer Immunotherapy Efficacy Influenced by Patient’s Sex
18 May, 2018 | 02:29h | UTCCancer immunotherapy efficacy and patients’ sex: a systematic review and meta-analysis – The Lancet Oncology (link to abstract – $ for full-text)
Commentaries: Patient’s sex might affect immunotherapy outcomes – OnMedica (free) AND Men Do Better than Women on Cancer Immunotherapies – MedPage Today (free registration required) AND Patients’ sex may impact efficacy of immunotherapy in cancer treatment – eCancer News (free)
Disease Outbreak: Ebola Case Confirmed in Urban Area of DRC
18 May, 2018 | 02:30h | UTCCommentary: As Ebola hits major DRC city, WHO convenes emergency panel – CIDRAP (free) AND WHO to weigh declaration of international emergency over Ebola outbreak – STAT (free) AND Congo and WHO race to prevent runaway Ebola outbreak – Reuters (free) AND Fears of Larger Contagion as Ebola Spreads to Major Congo City The New York Times (10 articles per month are free)
Cross-Sectional Study: Association of Disrupted Circadian Rhythmicity with Mood Disorders
18 May, 2018 | 02:31h | UTCAssociation of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank – The Lancet Psychiatry (link to abstract – for full-text)
Commentaries: Disrupted sleep-wake cycle linked to mental health problems – new study – The Conversation (free) AND Study: Body clock disruption linked to mood disorders – UPI (free) AND Body clock disruptions linked to mood disorders – NHS Choices (free) AND Maintaining a daily rhythm is important for mental health, study suggests – CNN (free)
Fri, May 18 – 10 Stories of The Day!
18 May, 2018 | 02:10h | UTC
1 – Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Inhaled Combined Therapy as Needed in Mild Asthma (free)
Related Trial: As-Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: International Study Suggests Alternative Treatment for Mild Asthma – McMaster University, via NewsWise (free) AND On Demand as Effective as Maintenance Therapy for Mild Asthma – Medscape (free registration required)
Commentaries: Exercise Doesn’t Slow Cognitive Decline in Patients with Dementia – NEJM Physician’s First Watch (free) AND Rigorous exercise does not halt dementia decline, study concludes – The Guardian (free) AND Expert reaction to effects of exercise on dementia in old people – Science Media Centre (free) AND Exercise ‘doesn’t slow’ progression of dementia – NHS Choices (free)
Commentaries: As Ebola hits major DRC city, WHO convenes emergency panel – CIDRAP (free) AND WHO to weigh declaration of international emergency over Ebola outbreak – STAT (free) AND Congo and WHO race to prevent runaway Ebola outbreak – Reuters (free) AND Fears of Larger Contagion as Ebola Spreads to Major Congo City The New York Times (10 articles per month are free)
4 – Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank – The Lancet Psychiatry (link to abstract – for full-text)
Commentaries: Disrupted sleep-wake cycle linked to mental health problems – new study – The Conversation (free) AND Study: Body clock disruption linked to mood disorders – UPI (free) AND Body clock disruptions linked to mood disorders – NHS Choices (free) AND Maintaining a daily rhythm is important for mental health, study suggests – CNN (free)
5 – Psychological therapies for treatment-resistant depression in adults – Cochrane Library (free)
Summary: Are psychological therapies effective in treating depression that did not get better with previous treatment? – Cochrane Library (free)
6 – Chemotherapy-Induced Peripheral Neuropathy in Long-term Survivors of Childhood Cancer: Clinical, Neurophysiological, Functional, and Patient-Reported Outcomes – JAMA Neurology (free for a limited period)
Commentaries: Peripheral Neuropathy Common in Childhood Cancer Survivors – MPR (free) AND Chemo-Induced Neuropathy Common after Childhood Cancer – MedPage Today (free registration required)
7 – Opinion: The ten pitfalls of lactate clearance in sepsis – Intensive Care Medicine (free)
Source: Critical Care Reviews Newsletter
Commentary: EAS Consensus Document Examines Safety of Statins Beyond Muscle Symptoms – TCTMD (free)
10 – Summary: The Practice of Cardio-Oncology in Spain: Position Statement From Scientific Societies Involved in Cancer and Heart Disease – American College of Cardiology (free)
Original Guideline: Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations – Revista Espanola de Cardiologia (free)
Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)
Randomized Controlled Trial: Exercise Training Does Not Slow Dementia Progression
18 May, 2018 | 02:29h | UTCCommentaries: Exercise Doesn’t Slow Cognitive Decline in Patients with Dementia – NEJM Physician’s First Watch (free) AND Rigorous exercise does not halt dementia decline, study concludes – The Guardian (free) AND Expert reaction to effects of exercise on dementia in old people – Science Media Centre (free) AND Exercise ‘doesn’t slow’ progression of dementia – NHS Choices (free)
Randomized Controlled Trials: Treatments for Mild Asthma Compared
18 May, 2018 | 02:28h | UTCInhaled Combined Budesonide–Formoterol as Needed in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Inhaled Combined Therapy as Needed in Mild Asthma (free)
Related Trial: As-Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: International Study Suggests Alternative Treatment for Mild Asthma – McMaster University, via NewsWise (free) AND On Demand as Effective as Maintenance Therapy for Mild Asthma – Medscape (free registration required)