Daily Archives: April 27, 2018
Polypharmacy Guidance, Realistic Prescribing
27 Apr, 2018 | 02:58h | UTCPolypharmacy Guidance, Realistic Prescribing 3 rd Edition, 2018 – Scottish Government Polypharmacy Model of Care Group (free PDF) (via @trishgreenhalgh)
Related Reviews: Current and future perspectives on the management of polypharmacy – BMC Family Medicine (free) AND Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety (free) AND Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international (free) AND Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety (free)
“Just because we can, doesn’t mean we should” – supporting informed decision-making
27 Apr, 2018 | 02:56h | UTC
Guideline: Pharmacologic Glycemic Management of Type 2 Diabetes in Adults
27 Apr, 2018 | 02:59h | UTCGuideline: Pharmacologic Glycemic Management of Type 2 Diabetes in Adults – Canadian Journal of Diabetes (free)
Related Guidelines: ADA 2018 Standards of Medical Care in Diabetes (free) AND ACP Guideline: Hemoglobin A1c Targets for Glycemic Control in Type 2 Diabetes (free)
In this new guideline Hemoglobin A1c Targets are similar from ADA 2018 Standards.
Perspective: The Mediterranean Diet’s Fight Against Frailty
27 Apr, 2018 | 02:54h | UTCThe Mediterranean Diet’s Fight Against Frailty – JAMA (free for a limited period)
ACOG Committee Opinion: Adolescents and Long-Acting Reversible Contraception
27 Apr, 2018 | 02:57h | UTCCommittee Opinion: Adolescents and Long-Acting Reversible Contraception: Implants and Intrauterine Devices – American College of Obstetrics and Gynecology (free)
Commentary: ACOG Committee Opinion: adolescents should be offered LARC – Univadis (free registration required)
Incorporating Medication Indications Into the Prescribing Process
27 Apr, 2018 | 02:53h | UTCSource: Hospital Medicine Virtual Journal Club (free)
Randomized Controlled Trial: Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa
27 Apr, 2018 | 02:53h | UTCAzithromycin to Reduce Childhood Mortality in Sub-Saharan Africa – New England Journal of Medicine (free)
Quick Take Video Summary: Azithromycin to Reduce Childhood Mortality (free)
Commentaries: Giving Antibiotics To Healthy Kids In Poor Countries: Good Idea Or Bad Idea? – NPR (free) AND Infant Deaths Fall Sharply in Africa With Routine Antibiotics – The New York Times (free) AND Giving at-risk children pre-emptive antibiotics reduces deaths – Nature (free)
Observational Study: Age and Sex of Surgeons and Mortality of Older Surgical Patients
27 Apr, 2018 | 02:44h | UTCAge and sex of surgeons and mortality of older surgical patients: observational study – The BMJ (free)
Editorial: Links between age and sex of surgeons and patients’ outcomes (free)
Commentary: Study Suggests Older Surgeons Produce Lower Mortality Rates in Emergency Procedures – UCLA, via NewsWise (free)
Randomized Controlled Trial: BNP Guided Therapy in Acute Decompensated Heart Failure
27 Apr, 2018 | 02:40h | UTCNT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide)-Guided Therapy in Acute Decompensated Heart Failure – Circulation (link to abstract – $ for full-text)
Related Systematic Review: Effectiveness and cost-effectiveness of serum B-type natriuretic peptide testing and monitoring in patients with heart failure in primary and secondary care: an evidence synthesis, cohort study and cost-effectiveness model – Health Technology Assessment (free) AND Commentary: Uncertain benefits of BNP blood tests to monitor heart failure treatment – NIHR Signal (free)
Related AHA Scientific Statement: Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure (free)
Source: EvidenceAlerts
“NT Pro BNP guided heart failure treatment no better than usual care”. (via @doctorvec)
Research: Targeted Mass Drug Administration on Plasmodium Falciparum Malaria
27 Apr, 2018 | 02:42h | UTCCommentaries: Can improving access to care help to eliminate malaria? – The Lancet (free) AND Dose entire population with anti-malaria drugs to eradicate disease – study – The Guardian (free) AND Malaria studies show benefit of mass treatment, methylene blue – CIDRAP (free)
Related: Seminar: Malaria (free registration required) Series: Malaria in Pregnancy (free registration required)
Review: Optimised Care of Elderly Patients with Acute Coronary Syndrome
27 Apr, 2018 | 02:39h | UTCOptimised care of elderly patients with acute coronary syndrome – European Heart Journal: Acute Cardiovascular Care (free) (via @krychtiukmd see Tweet)
Case-control Study: Anticholinergic Drugs and Risk of Dementia
27 Apr, 2018 | 02:38h | UTCAnticholinergic drugs and risk of dementia: case-control study – The BMJ (free)
Editorial: Anticholinergic drugs and dementia in older adults (free)
Commentaries: Expert reaction to study investigating the association between different types of anticholinergic drugs and risk of dementia – Science Media Centre (free) AND Anticholinergic drugs may be linked to increased risk of dementia – OnMedica (free)
“The effect of anticholinergic therapy is relatively small (odds ratio 1.1 – 1.2) and establishing an association does not prove a causal link. Nevertheless, the paper may act as a useful guide for future research and clinical practice”. (by Prof Les Iversen, in Science Media Centre)
Meta-Analysis: Probiotics for the Prevention of Clostridium difficile
27 Apr, 2018 | 02:36h | UTCCommentary: Probiotics may be safe, low-cost prevention tool for Clostridium difficile infections – News Medical (free)
Related Articles: The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use – Cochrane Library (free) AND Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis – Antibiotics (free) AND Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis – Gastroenterology (free)
A Cancer Drug Tailored to Your Tumor? Experts Trade Barbs Over ‘Precision Oncology’
27 Apr, 2018 | 02:35h | UTCA cancer drug tailored to your tumor? Experts trade barbs over ‘precision oncology’ – Science (free)
See also: Audio and slides on the meeting webcast (free) (via @barttels2 and @AACRPres see Tweet)
Clinical Guideline: HIV Pre-exposure Prophylaxis
27 Apr, 2018 | 02:32h | UTCRelated guidelines: WHO implementation tool for pre-exposure prophylaxis of HIV infection – World Health Organization (free) AND Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis – Canadian Medical Association Journal (free) AND Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update: a Clinical Practice Guideline (free)
Research: Physicians’ Use of an Examination Room Computer and Patient Satisfaction
27 Apr, 2018 | 02:34h | UTCPhysicians’ Compassion, Communication Skills, and Professionalism With and Without Physicians’ Use of an Examination Room Computer: A Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)
Commentaries: Patients Prefer Doctors Who Engage in Face-to-Face Visits – Physician’s Briefing (free) AND Docs Behind Screen Seen as Less Compassionate – MedPage Today (free registration required) AND Patients value eye contact from physicians: study – Univadis (free registration required)
Meta-Analysis: Uterotonic Agents for Preventing Postpartum Haemorrhage
27 Apr, 2018 | 02:31h | UTCUterotonic agents for preventing postpartum haemorrhage: a network meta-analysis – Cochrane Library (free for a limited period)
News Release: Featured Review: Uterotonic agents for preventing postpartum haemorrhage – Cochrane Library (free)
Commentary: Review finds more effective drugs to stop bleeding after childbirth – University of Birmingham (free)
“New Cochrane Review suggests ergometrine plus oxytocin; misoprostol plus oxytocin; & carbetocin on its own, are more effective drugs for reducing excessive bleeding at childbirth rather than the current standard use of oxytocin on its own” (via @CochraneUK see Tweet)
NICE Guideline Update: Neuropathic pain in adults
27 Apr, 2018 | 02:29h | UTCGuideline Update: Neuropathic pain in adults: pharmacological management in non-specialist settings – National Institute for Health and Care Excellence (free)
NICE Guideline Update: Antenatal and Postnatal Mental Health
27 Apr, 2018 | 02:30h | UTCGuideline Update: Antenatal and postnatal mental health: clinical management and service guidance – National Institute for Health and Care Excellence (free)
AHA Scientific Statement: Cardiopulmonary Resuscitation in Infants and Children With Cardiac Disease
27 Apr, 2018 | 02:28h | UTCNews release: New guidance issued for treating cardiac arrest in children with heart disease (free)
Top Ten Things to Know: Cardiopulmonary Resuscitation in Infants and Children with Cardiac Disease (free PDF)
RCT: Ticagrelor Plus Aspirin, Ticagrelor Alone, or Aspirin Alone on Saphenous Vein Graft Patency
27 Apr, 2018 | 02:27h | UTCEffect of Ticagrelor Plus Aspirin, Ticagrelor Alone, or Aspirin Alone on Saphenous Vein Graft Patency 1 Year After Coronary Artery Bypass Grafting: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: Ticagrelor + Aspirin, Ticagrelor Alone, or Aspirin Alone on SVG Patency – American College of Cardiology, Latest in Cardiology (free)
““The major limitation of the DACAB trial is the selection of vein graft patency as the primary outcome”. Agree:we’re starting to understand CAD is a bit more complicated than an open duct (also for this reason, medical practice requires clinical outcomes)” (via @camialderighi see Tweet)
Research: Avoid Piperacillin-tazobactam When Treating BSI Caused by Ceftriaxone-resistant Pathogens
27 Apr, 2018 | 02:25h | UTC28th ECCMID: The MERINO Trial: piperacillin-tazobactam versus meropenem for the definitive treatment of bloodstream infections caused by third-generation cephalosporin nonsusceptible Escherichia coli or Klebsiella spp.: an international multi-centre openlabel non-inferiority randomised controlled trial (free abstract)
Commentaries: Avoid piperacillin-tazobactam when treating BSI cause by ceftriaxone-resistant pathogens – European Society of Clinical Microbiology and Infectious Diseases, via EurekAlert (free) AND Combo antibiotic found inferior for MDR bloodstream infections – CIDRAP (free)
Debate: Should we Recommend e-Cigarettes to Help Smokers Quit?
27 Apr, 2018 | 01:36h | UTCShould we recommend e-cigarettes to help smokers quit? – The BMJ (free)
See also: related guidelines, reports and commentaries on e-cigarettes
“Experts debate: Should doctors recommend e-cigarettes to help smokers quit? Revelation in harm reduction or a way to keep people addicted and gateway to youth smoking?” (via @rich_hurley see Tweet)
Fri, April 27 – 10 Stories of The Day!
27 Apr, 2018 | 01:39h | UTC
Commentary: Probiotics may be safe, low-cost prevention tool for Clostridium difficile infections – News Medical (free)
Related Articles: The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use – Cochrane Library (free) AND Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis – Antibiotics (free) AND Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis – Gastroenterology (free)
2 – Anticholinergic drugs and risk of dementia: case-control study – The BMJ (free)
Editorial: Anticholinergic drugs and dementia in older adults (free)
Commentaries: Expert reaction to study investigating the association between different types of anticholinergic drugs and risk of dementia – Science Media Centre (free) AND Anticholinergic drugs may be linked to increased risk of dementia – OnMedica (free)
“The effect of anticholinergic therapy is relatively small (odds ratio 1.1 – 1.2) and establishing an association does not prove a causal link. Nevertheless, the paper may act as a useful guide for future research and clinical practice”. (by Prof Les Iversen, in Science Media Centre)
3 – Age and sex of surgeons and mortality of older surgical patients: observational study – The BMJ (free)
Editorial: Links between age and sex of surgeons and patients’ outcomes (free)
Commentary: Study Suggests Older Surgeons Produce Lower Mortality Rates in Emergency Procedures – UCLA, via NewsWise (free)
4 – Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis – Cochrane Library (free for a limited period)
News Release: Featured Review: Uterotonic agents for preventing postpartum haemorrhage – Cochrane Library (free)
Commentary: Review finds more effective drugs to stop bleeding after childbirth – University of Birmingham (free)
“New Cochrane Review suggests ergometrine plus oxytocin; misoprostol plus oxytocin; & carbetocin on its own, are more effective drugs for reducing excessive bleeding at childbirth rather than the current standard use of oxytocin on its own” (via @CochraneUK see Tweet)
5 – Optimised care of elderly patients with acute coronary syndrome – European Heart Journal: Acute Cardiovascular Care (free) (via @krychtiukmd see Tweet)
6 – Perspective: The Mediterranean Diet’s Fight Against Frailty – JAMA (free for a limited period)
7 – Committee Opinion: Adolescents and Long-Acting Reversible Contraception: Implants and Intrauterine Devices – American College of Obstetrics and Gynecology (free)
Commentary: ACOG Committee Opinion: adolescents should be offered LARC – Univadis (free registration required)
Related guidelines: WHO implementation tool for pre-exposure prophylaxis of HIV infection – World Health Organization (free) AND Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis – Canadian Medical Association Journal (free) AND Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update: a Clinical Practice Guideline (free)
10 – NT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide)-Guided Therapy in Acute Decompensated Heart Failure – Circulation (link to abstract – $ for full-text)
Related Systematic Review: Effectiveness and cost-effectiveness of serum B-type natriuretic peptide testing and monitoring in patients with heart failure in primary and secondary care: an evidence synthesis, cohort study and cost-effectiveness model – Health Technology Assessment (free) AND Commentary: Uncertain benefits of BNP blood tests to monitor heart failure treatment – NIHR Signal (free)
Related AHA Scientific Statement: Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure (free)
Source: EvidenceAlerts
“NT Pro BNP guided heart failure treatment no better than usual care”. (via @doctorvec)
Systematic Review: Sending Patient Reminders Improves Immunisation Uptake
27 Apr, 2018 | 01:37h | UTCSending patient reminders improves immunisation uptake – NIHR Signal (free)
Original article: Patient reminder and recall interventions to improve immunization rates – Cochrane Library (link to abstract – $ for full-text)