RCT | Effect of intranasal Dexmedetomidine or Midazolam for premedication on the occurrence of respiratory adverse events in children undergoing tonsillectomy and adenoidectomy.

Effect of Intranasal Dexmedetomidine or Midazolam for Premedication on the Occurrence of Respiratory Adverse Events in Children Undergoing Tonsillectomy and Adenoidectomy: A Randomized Clinical Trial – JAMA Network Open

Commentaries:

Perioperative Respiratory Adverse Events After Pediatric Adenotonsillectomy—Evaluating the Role of Preoperative Pharmacologic Anxiolysis – JAMA Network Open

Dexmedetomidine Cuts Perioperative Respiratory AEs in Tonsillectomy – HealthDay

Commentary on Twitter

Children often required sedatives before surgery due to anxiety and crying. In this RCT, intranasal midazolam increased the incidence of perioperative respiratory adverse events (PRAEs), while intranasal dexmedetomidine reduced PRAEs. #OrigInvestigation https://t.co/5AAILuzstM pic.twitter.com/WejpGkAGGs

— JAMA Network Open (@JAMANetworkOpen) August 9, 2022