Systematic Review: Timing of antibiotic administration, wound debridement, and the stages of reconstructive surgery for open long bone fractures of the upper and lower limbs. 5 Apr, 2022 | 08:08h | UTC Timing of antibiotic administration, wound debridement, and the stages of reconstructive surgery for open long bone fractures of the upper and lower limbs – Cochrane Library Summary: The timing of treatment for broken bones in the legs and arms that also have open wounds – Cochrane Library