Lessons from a Superb Clinical Trial – commentary on a recent randomized trial testing left atrial appendage occlusion during cardiac surgery to prevent stroke.

Lessons from a Superb Clinical Trial – by Dr. John Mandrola

Original Study: #ACC21 – Practice Changing RCT: In patients with atrial fibrillation (75% maintained on anticoagulation), left atrial appendage occlusion during cardiac surgery reduces the incidence of stroke and systemic embolism (4.8 vs. 7.0%) in the following years.