RCT: Postoperative pain control is improved with Methadone + Ketamine vs. Methadone alone in spinal surgical patients

Perioperative Methadone and Ketamine for Postoperative Pain Control in Spinal Surgical Patients: A Randomized, Double-blind, Placebo-controlled Trial – Anesthesiology (link to abstract – $ for full-text)

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In a randomized trial of 130 spinal surgery patients, adding ketamine to methadone reduced pain scores from 4 to 2 points on an 11-point Likert scale and roughly halved postoperative opioid use https://t.co/vGVuQ7z7HV

— Anesthesiology journal (@_Anesthesiology) March 19, 2021