Randomized trial: Safety and efficacy of long-term mild hypothermia for severe traumatic brain injury with refractory intracranial hypertension

Safety and efficacy of long-term mild hypothermia for severe traumatic brain injury with refractory intracranial hypertension (LTH-1): A multicenter randomized controlled trial – EClinicalMedicine

Commentary on Twitter

Does induced hypothermia/targetted temp management improve outcomes in patients with traumatic brain injury?

Maybe or maybe not

But this trial slow to cool, not very cool, underpowered and mod rate of dropout

Prob does not answer questionhttps://t.co/UGRFmUVNV0 pic.twitter.com/c0iDqj2l2e

— Graham Nichol (@grahamnichol) January 29, 2021