Wed August 7 – 10 Stories of The Day!

1 – Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

See also: Summary of Recommendations (free PDF) AND Visual Abstract (free PDF)

2 – Screening for Pancreatic Cancer: US Preventive Services Task Force Reaffirmation Recommendation Statement (free)

Evidence Report: Screening for Pancreatic Cancer: Systematic Review for the US Preventive Services Task Force (free)

Editorials: Screening for Pancreatic Cancer – JAMA (free for a limited period) AND Screening for Pancreatic Cancer—Is There Hope? – JAMA Internal Medicine (free for a limited period) AND Screening for Pancreatic Cancer Gets a D, But the Student Is Improving – JAMA Surgery (free for a limited period)

3 – Transfusion Volume for Children with Severe Anemia in Africa – New England Journal of Medicine (free)

Commentary: Larger blood transfusions could halve deaths of children with severe anaemia – Imperial College London (free)

Related Study: Immediate Transfusion in African Children with Uncomplicated Severe Anemia – New England Journal of Medicine (free)

4 – Association of Office and Ambulatory Blood Pressure With Mortality and Cardiovascular Outcomes – JAMA (free for a limited period)

Editorial: Effective Use of Ambulatory Blood Pressure Monitoring (free)

Commentaries: Blood pressure recording over 24 hours is the best predictor of heart and vascular disease – KU Leuven (free) AND Nighttime, 24-Hour BP Readings Have Strongest Link to Poor Outcomes – TCTMD (free)

5 – Metformin Use and Clinical Outcomes among Patients with Diabetes with or without Heart Failure or Kidney Dysfunction: Observations from the SAVOR-TIMI 53 Trial – Circulation (link to abstract – $ for full-text)

Commentaries: Metformin Use and CV Outcomes Among Diabetes Patients – American College of Cardiology (free) AND Support for metformin cardioprotective effect – Medicine Matters (free) AND Metformin Use Associated With Lower Death Risk in Type 2 Diabetes – Renal & Urology News (free)

Related: Effect of metformin on all-cause and cardiovascular mortality in patients with coronary artery diseases: a systematic review and an updated meta-analysis – Cardiovascular Diabetology (free)

6 – These Medical Devices Are Inserted Into 500,000 Patients Each Year — but Are Tough to Sterilize – The New York Times (10 articles per month are free)

Related: Prevention of multidrug-resistant infections from contaminated duodenoscopes: Position Statement of the European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastroenterology Nurses and Associates (ESGENA) (free) AND An update on gastrointestinal endoscopy-associated infections and their contributing factors – Annals of Clinical Microbiology and Antimicrobials (free) AND Carbapenem Resistant Enterobacteriaceae and Endoscopy: An Evolving Threat – American Journal of Infection Control (free) AND Hygiene: The Looming Achilles Heel in Endoscopy – Visceral Medicine (free) AND Superbugs on Duodenoscopes: the Challenge of Cleaning and Disinfection of Reusable Devices – Journal of Clinical Microbiology (free)

7 – American Academy of Pediatrics – Section on Rheumatology: Five Things Physicians and Patients Should Question – Choosing Wisely (free)

Commentary: New Choosing Wisely List Tackles Opioid Prescribing, Lyme Testing – NEJM Journal Watch (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

8 – Hereditary gastrointestinal cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up – Annals of Oncology (free PDF)

Related: ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes (free)

9 – Series from the Lancet journals: Genomic medicine – The Lancet (free articles – registration required)

10 – Assessment of Therapeutic Interventions and Lung Protective Ventilation in Patients With Moderate to Severe Acute Respiratory Distress Syndrome: A Systematic Review and Network Meta-analysis – JAMA Network Open (free)

Related Guidelines: Formal guidelines: management of acute respiratory distress syndrome – Annals of Intensive Care (free) AND Guidelines on the management of acute respiratory distress syndrome – BMJ Open Respiratory Research (free) AND Guidelines On The Management Of Acute Respiratory Distress Syndrome – Intensive Care Society (free PDF) AND The clinical practice guideline for the management of ARDS in Japan – Journal of Intensive Care (free) AND An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome (free)

Related Review: Acute Respiratory Distress Syndrome – Nature Reviews Disease Primer (free PDF)

“This network meta-analysis supports the use of prone positioning and venovenous extracorporeal membrane oxygenation in addition to lung protective ventilation in patients with ARDS.”