Open access
Top10 Stories of The Day
25 Nov, 2020-
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Cluster-randomized trial: Postexposure hydroxychloroquine does not prevent Covid-19 in healthy persons exposed to a PCR-positive case patient »
New England Journal of Medicine -
With more data on its COVID-19 vaccine, Russian institute offers new evidence of success »
Science -
[Preprint] Study shows cloth face coverings help protect both wearers and those nearby. Study design represents conditions closer to real-world use, with the control of laboratory testing »
Virginia Tech / medRxiv -
Latest COVID-19 guidelines come out against bamlanivimab, remdesivir »
ACP Internist -
Opinion: “Children may transmit coronavirus at the same rate as adults: what we now know about schools and COVID-19” »
The Conversation -
Systematic review: Financial payments from the pharmaceutical industry is associated with more physician prescribing of the drug made by the company that they got the payments from »
Annals of Internal Medicine -
Randomized trial: Colorectal cancer screening with repeated fecal immunochemical tests detects more colorectal cancer and advanced adenomas compared to screening sigmoidoscopy »
Gastroenterology -
Randomized trial: Prednisone is an effective short-term preventive therapy in patients with episodic cluster headache »
The Lancet Neurology -
USPSTF Statement recommends regular behavioral counseling on healthy diet and physical activity to prevent cardiovascular disease »
US Preventive Services Task Force / JAMA
Latest Research, Guidelines & Perspectives
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Kids’ COVID cases on the rise, but most are mild, new studies show »
CIDRAP / Pediatrics / JAMA Pediatrics -
Diagnosis, management, and pathophysiology of arterial and venous thrombosis in COVID-19 »
JAMA -
Why the AstraZeneca-Oxford Covid-19 vaccine is different. It does not require extremely cold temperatures for storage, and the price will be “a fraction” of the expense of the other vaccine candidates »
Vox -
Why does the AstraZeneca-Oxford COVID-19 vaccine’s efficacy vary so much? Here’s what we know »
TIME -
Emergency COVID-vaccine approvals pose a dilemma for scientists. It could complicate efforts to study long-term outcomes, such as safety, how long protection lasts and whether the jab prevents infection or just the disease »
Nature -
Four reasons why we need multiple vaccines for Covid-19 »
Wellcome Trust -
Data show hospitalized Covid-19 patients are surviving at higher rates, but surge in cases could roll back gains »
STAT -
Opinion – Football and dementia: heading must be banned until the age of 18 »
The Conversation -
Podcast: Diabetes Triple Distilled. Pitfalls of A1c testing, different guidelines for A1C targets, when and how to use the newer medications such as SGLT-2 inhibitors and GLP-1 agonists, and more »
The Curbsiders Internal Medicine Podcast -
Randomized, placebo-controlled, crossover trial: Amantadine, modafinil, and methylphenidate are no better than placebo for fatigue in multiple sclerosis »
The Lancet Neurology
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Covid-19: Oxford University vaccine shows 70% protection »
University of Oxford / BBC -
Meta-analysis: SARSCoV2 most contagious within the first 5 days of symptom onset »
The Lancet Microbe -
Cochrane review finds we are still uncertain about the effects of face masks to reduce the spread of respiratory viruses. Editorial: “Policy makers must act on incomplete evidence in responding to COVID‐19” »
Cochrane Library -
Trends in COVID-19 incidence in counties with and without a mask mandate. Counties with mask mandates saw a decrease in cases compared to counties that didn’t »
CDC Morbidity and Mortality Weekly Report -
A proposed framework and timeline of the spectrum of disease due to SARS-CoV-2 infection: Illness beyond acute infection and public health implications »
JAMA -
Covid-19 screening: Test sensitivity is less important than frequency and sample-to-answer reporting time »
Science Advances -
2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy »
American College of Cardiology/American Heart Association -
Systematic review: Ultra-long‐acting insulins provide modest benefit compared to NPH insulin for Type 2 DM, resulting in reduced risk of hypoglycemia but no difference in HbA1c »
Cochrane Library -
Randomized trial: No difference in oral health with a risk-based, 6-monthly and 24-monthly dental check-ups for adults »
Health Technology Assessment -
Systematic review: Interventions for breathlessness in patients with advanced cancer »
Agency for Healthcare Research and Quality