[Preprint] Past COVID-19 infection provides some immunity but people may still carry and transmit virus » Public Health England / The BMJ / Nature
Observational study: Among patients hospitalized with Covid-19 not receiving mechanical ventilation, transfusion of plasma with higher anti–SARS-CoV-2 IgG antibody levels is linked to lower risk of death than transfusion of plasma with lower antibody levels » New England Journal of Medicine
NIH Guideline Statement: “there are insufficient data to recommend either for or against the use of ivermectin for the treatment of COVID-19” » National Institutes of Health
Perspective: Ivermectin for COVID-19 — Breakthrough Treatment or Hydroxychloroquine Redux? » HIV and ID Observations
Covid-19 deaths are the highest they’ve ever been — and the more infectious variants could make things much worse » STAT
Meta-analysis of randomized trials: patients adhering to a low carbohydrate diet for six months may experience remission of diabetes without adverse consequences » The BMJ
Meta-analysis of randomized trials: SGLT-2 inhibitors and GLP-1 receptor agonists reduce cardiovascular and renal outcomes in type 2 diabetes » The BMJ
Cohort study: Even small amounts of alcohol consumption linked to increased risk of atrial fibrillation » European Heart Journal
Randomized trial: Naltrexone-Bupropion combination may help some people (13.6% vs. 2.5% with placebo) with methamphetamine use disorder » New England Journal of Medicine
Study: Pulmonary embolism detected in 6% of patients with COPD admitted to the hospital with acute worsening of respiratory symptoms » JAMA
Consequences to patients, clinicians, and manufacturers when very serious adverse drug reactions are identified (1997–2019) » EClinicalMedicine
Cohort study: Piperacillin/tazobactam linked to increased risk of acute kidney injury when compared to cefepime or meropenem » Clinical Infectious Diseases
Randomized trial: Surgical and drug treatment options lead to similar outcomes for diabetic eye disease » JAMA
[Abstract Only] A randomized clinical trial of low dose warfarin therapy for improving the longevity of permanent arteriovenous catheters » Annals of Vascular Surgery
Randomized trial: Biological mesh results in significantly more complications compared to synthetic mesh in noncomplex ventral hernia repair » Annals of Surgery
Randomized trial: Cannula with long and narrow tubing noninferior to short binasal prongs for noninvasive ventilation in preterm infants » JAMA Pediatrics
CSCO and ASCO Guideline: Chemotherapy in combination with radiotherapy for definitive-intent treatment of stage II-IVA nasopharyngeal carcinoma » American Society of Clinical Oncology
Randomized trial: Once-per-week selinexor, bortezomib, and dexamethasone versus twice-per-week bortezomib and dexamethasone in patients with multiple myeloma » The Lancet
Systematic review: Prostatic arterial embolization for men with symptomatic benign prostatic hyperplasia provides similar short term (up to 12 months) improvement in urologic symptom scores and quality of life, but with an increase in re-treatment rates » Cochrane Library
Systematic review: Adding abiraterone acetate to androgen deprivation therapy for the treatment of metastatic hormone-sensitive prostate cancer » Cochrane Library
Systematic review: Oral hygiene care with chlorhexidine mouthwash or gel in critically ill patients probably reduces the incidence of developing ventilator-associated pneumonia » Cochrane Library