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Systematic Reviews

Systematic Review: SARS-CoV-2 Infection in Children and Adolescents

23 Apr, 2020 | 09:40h | UTC

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review – JAMA Pediatrics

Commentaries: Most kids with coronavirus usually recover within two weeks, JAMA study finds – CNBC AND Young people at lower risk for COVID-19, can still transmit the virus – UPI AND Expert reaction to systematic review of COVID-19 in children – Science Media Centre


Systematic Review: Intra‐pleural Fibrinolytic Therapy for the Treatment of Parapneumonic Effusions and Empyema

31 Oct, 2019 | 08:18h | UTC

Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult parapneumonic effusions and empyema – Cochrane Library (free)

Summary: Clot-busting drugs for infections of the lining of the lung – Cochrane Library (free)


Systematic Review: Antiplatelet Agents for Preventing Pre‐eclampsia and its Complications

1 Nov, 2019 | 07:54h | UTC

Antiplatelet agents for preventing pre‐eclampsia and its complications – Cochrane Library (free)

Summary: Antiplatelet agents for preventing pre-eclampsia and its complications – Cochrane Library (free)

Related Randomized Trial: Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia – New England Journal of Medicine (free study and commentaries)


Systematic Review: Azathioprine and 6‐mercaptopurine for Maintenance of Surgically‐induced Remission in Crohn’s Disease

1 Oct, 2019 | 00:34h | UTC

Azathioprine and 6‐mercaptopurine for maintenance of surgically‐induced remission in Crohn’s disease – Cochrane Library (free)

Summary: Azathioprine and 6-mercaptopurine for the maintenance of surgically-induced remission in Crohn’s disease – Cochrane Library (free)


Systematic Review: Beta-blockers to Prevent Death or Serious Events After Non-Cardiac Surgery

27 Sep, 2019 | 08:30h | UTC

Perioperative beta‐blockers for preventing surgery‐related mortality and morbidity in adults undergoing non‐cardiac surgery – Cochrane Library (free)

Summary: Beta-blockers to prevent death or serious events after surgery not involving the heart – Cochrane Library (free)


Systematic Review: Non‐steroidal Anti‐inflammatory Drugs for Heavy Menstrual Bleeding

24 Sep, 2019 | 08:10h | UTC

Non‐steroidal anti‐inflammatory drugs for heavy menstrual bleeding – Cochrane Library (free)

Summary: Are non-steroidal anti-inflammatory drugs safe and effective for treating heavy menstrual bleeding? – Cochrane Library (free)


Systematic Review: Delayed Cord Clamping May Reduce the Risk of Death Before Discharge for Babies Born Preterm

23 Sep, 2019 | 01:03h | UTC

Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes – Cochrane Library (free)

Summary: Does delaying cord clamping or using cord milking at birth improve the health of babies born too early? – Cochrane Library (free)

Related: Delayed umbilical cord clamping reduces hospital mortality for preterm infants (free) AND Cohort Study: Delayed Cord Clamping is Associated with Reduced Odds of Severe Neurological Injury or Mortality in Extremely Low-gestational-age Neonates (free) AND Randomized Trial: Delayed Clamping vs Milking of Umbilical Cord in Preterm Infants (link to abstract)


Related Commentary on Twitter


Cochrane Special Collection: Diagnosing Dementia

20 Sep, 2019 | 08:06h | UTC

Cochrane Special Collection: Diagnosing Dementia – Cochrane Library (free articles)

Commentary: Dementia diagnosis: a decade of evidence – Evidently Cochrane (free)


Meta-Analysis: Parenteral Methotrexate Better Than Oral MTX for Achieving Reduction in Disease Activity in Patients with Rheumatoid Arthritis

15 Sep, 2019 | 23:59h | UTC

Comparison of oral versus parenteral methotrexate in the treatment of rheumatoid arthritis: A meta-analysis – PLOS One (free)

Commentary: Rheumatoid arthritis: parenteral MTX tops pills for efficacy – Univadis (free registration required)


Systematic Review: Follow‐up Strategies for Patients Treated for Non‐metastatic Colorectal Cancer

11 Sep, 2019 | 00:03h | UTC

Follow‐up strategies for patients treated for non‐metastatic colorectal cancer – Cochrane Library (free)

Summary: Follow-up strategies for participants treated for non-metastatic colorectal cancer – Cochrane Library (free)


A Systematic Review of Clinical Guidelines on the Management of Acute, Community-acquired CNS Infections

9 Sep, 2019 | 00:07h | UTC

A systematic review of clinical guidelines on the management of acute, community-acquired CNS infections – BMC Medicine (free)

Related: The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults (free) AND ESCMID guideline: diagnosis and treatment of acute bacterial meningitis (free) AND Meningitis (bacterial) and meningococcal septicaemia in under 16s: recognition, diagnosis and management – National Institute for Health and Care Excellence (free) AND Management of suspected viral encephalitis in adults – Association of British Neurologists and British Infection Association National Guidelines (free) AND Management of suspected viral encephalitis in children – Association of British Neurologists and British Paediatric Allergy, Immunology and Infection Group National Guidelines (free)


Systematic Review: Low‐carbohydrate Diets for Type 2 Diabetes Management

9 Sep, 2019 | 00:05h | UTC

An evidence‐based approach to developing low‐carbohydrate diets for type 2 diabetes management: A systematic review of interventions and methods – Diabetes, Obesity and Metabolism (free)

Source: EvidenceAlerts


Meta-Analysis: Perioperative Fluid Restriction in Abdominal Surgery

8 Sep, 2019 | 23:54h | UTC

Perioperative Fluid Restriction in Abdominal Surgery: A Systematic Review and Meta-analysis – World Journal of Surgery (free)

Source: EvidenceAlerts


Systematic Review: Hypofractionation (Fewer, Larger Doses of Daily Radiation) for Clinically Localized Prostate Cancer Results in Similar Oncologic Outcomes

8 Sep, 2019 | 23:00h | UTC

Hypofractionation for clinically localized prostate cancer – Cochrane Library (free)


Systematic Review: Chlorhexidine Bathing of the Critically Ill for the Prevention of Hospital‐acquired Infection

8 Sep, 2019 | 23:01h | UTC

Chlorhexidine bathing of the critically ill for the prevention of hospital‐acquired infection – Cochrane Library (free)

Summary: Bathing critically ill patients with chlorhexidine to prevent hospital-acquired infections – Cochrane Library (free)

“Due to the very low-certainty evidence available, it is not clear whether bathing with chlorhexidine reduces hospital-acquired infections, mortality, or length of stay in the ICU”


Systematic Review: Taxanes for Adjuvant Treatment of Early Breast Cancer

8 Sep, 2019 | 22:59h | UTC

Taxanes for adjuvant treatment of early breast cancer – Cochrane Library (free)

Summary: Taxane-containing chemotherapy for women after surgery for early breast cancer – Cochrane Library (free)


Systematic Review: Antiarrhythmics for Maintaining Sinus Rhythm after Cardioversion of Atrial Fibrillation

6 Sep, 2019 | 09:03h | UTC

Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation – Cochrane Library (free)

Summary: Antiarrhythmics for maintaining sinus rhythm (normal heartbeat) after reversing atrial fibrillation (correcting an irregular heartbeat) – Cochrane Library (free)


Systematic Review of Guidelines and Consensus Statements: Diagnosis and Treatment for Hyperuricemia and Gout

4 Sep, 2019 | 08:36h | UTC

Diagnosis and treatment for hyperuricemia and gout: a systematic review of clinical practice guidelines and consensus statements – BMJ Open (free)

Related Guidelines: 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout – Annals of Rheumatic Disease (free) AND Management of Acute and Recurrent Gout: A Clinical Practice Guideline From the American College of Physicians (free) AND Diagnosis of Acute Gout: A Clinical Practice Guideline From the American College of Physicians (free) AND The British Society for Rheumatology Guideline for the Management of Gout – Rheumatology (free)


Systematic Review: Antipsychotics for Treating Delirium in Hospitalized Adults

3 Sep, 2019 | 01:29h | UTC

Antipsychotics for Treating Delirium in Hospitalized Adults: A Systematic Review – Annals of Internal Medicine (free)


Systematic Review: Antipsychotics for Preventing Delirium in Hospitalized Adults

3 Sep, 2019 | 01:27h | UTC

Antipsychotics for Preventing Delirium in Hospitalized Adults: A Systematic Review – Annals of Internal Medicine (free)


Meta-Analysis: Preoperative Physical Exercise Interventions in Patients with Non-Small-Cell Lung Cancer

27 Aug, 2019 | 00:15h | UTC

Systematic Review and Meta-Analysis of Randomized, Controlled Trials on Preoperative Physical Exercise Interventions in Patients with Non-Small-Cell Lung Cancer – Cancers (free)

Related: Preoperative exercise training for patients with non‐small cell lung cancer – Cochrane Library (free) AND Preoperative patient preparation in enhanced recovery pathways – Journal of Anaesthesiology Clinical Pharmacology (free)


Systematic Review: Early Experience with Transcatheter Mitral Valve Replacement

25 Aug, 2019 | 21:30h | UTC

Early Experience With Transcatheter Mitral Valve Replacement: A Systematic Review – Journal of the American Heart Association (free)

“TMVR was a feasible, less invasive alternative for treating severe mitral regurgitation in patients with high or prohibitive surgical risk”


Meta-Analysis: Quality of Dietary Fat and Genetic Risk of Type 2 Diabetes

25 Aug, 2019 | 21:07h | UTC

Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis – The BMJ (free)

Commentaries: Interventions for type 2 diabetes successful across the genetic landscape – Massachusetts General Hospital (free) AND Genetics no barrier to dietary modification benefits on type 2 diabetes risk – medwire News (free)


Meta-Analysis: Any Level of Physical Activity Decreases Risk of Premature Death

25 Aug, 2019 | 21:05h | UTC

Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonised meta-analysis – The BMJ (free)

Editorial: Every step you take – The BMJ (free)

Commentaries: “Sit less—move more and more often”: all physical activity is beneficial for longevity – The BMJ Opinion (free) AND ‘Sit less, move more’ may be key advice for living longer – NHS Choices (free) AND Every Little Step Helps – Any Physical Activity Linked to Decreased Mortality – (free)


Meta-Analysis: Global Incidence of Frailty and Prefrailty Among Community-Dwelling Older Adults

20 Aug, 2019 | 08:20h | UTC

Global Incidence of Frailty and Prefrailty Among Community-Dwelling Older Adults: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentaries: The Dynamics of Frailty Among Older Adults – JAMA Network Open (free) AND Frailty is a medical condition, not an inevitable result of aging – Monash University (free)

Related: Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report – Age and Ageing (free) AND A Review of Frailty Syndrome and Its Physical, Cognitive and Emotional Domains in the Elderly – Geriatrics (free) AND Frailty: Identifying elderly patients at high risk of poor outcomes – Canadian Family Physician (free)


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