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Cohort Study: Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection.

12 Apr, 2022 | 09:57h | UTC

Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a multicentre cohort study – Canadian Medical Association Journal

News Release: Children older than 5 at higher risk of COVID-19-related multisystem inflammatory syndrome – Canadian Medical Association Journal

Commentary: Older Kids More Vulnerable to MIS-C: Study – HealthDay

 

More data suggests the Omicron variant causes milder disease compared to the Delta variant.

12 Apr, 2022 | 09:49h | UTC

Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study – The Lancet

Commentary: Covid-19: Symptomatic infection with omicron variant is milder and shorter than with delta, study reports – The BMJ

Related:

Another study suggests a lower risk of hospitalization and death from infection with SARS-CoV-2 Omicron variant vs. Delta.

Perspective: Challenges in inferring intrinsic severity of the SARS-CoV-2 Omicron variant.

Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa.

Cohort Study: Incidence rates and clinical outcomes of SARS-CoV-2 infection with the Omicron and Delta variants in children younger than 5 years in the US.

[Preprint] SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters.

[Preprint] Study showed reduced clinical severity of Covid-19 patients admitted to hospitals in Gauteng, South Africa, during the Omicron-dominant fourth wave – “any combination of a less-virulent virus, comorbidities, high immunity from prior infection(s) or vaccination may be important contributors to this clinical presentation”.

Early data from South Africa hints Omicron variant may cause less severe Covid, but more research is needed.

Too early to tell, but preliminary information from doctors in South Africa suggests the new Covid variant Omicron may be associated with less severe disease.

 

COVID-19 disease severity in children infected with the Omicron variant.

12 Apr, 2022 | 09:47h | UTC

COVID-19 Disease Severity in Children Infected with the Omicron Variant – Clinical Infectious Diseases

Related: Cohort Study: Incidence rates and clinical outcomes of SARS-CoV-2 infection with the Omicron and Delta variants in children younger than 5 years in the US.

 

Commentary on Twitter

 

M-A: The clinical effect and safety of new preoperative fasting time guidelines for elective surgery.

12 Apr, 2022 | 09:51h | UTC

The clinical effect and safety of new preoperative fasting time guidelines for elective surgery: a systematic review and meta-analysis – Gland Surgery

Related:

An international multidisciplinary consensus statement on fasting before procedural sedation in adults and children – Anaesthesia

Does my hospitalized patient need an NPO-after-midnight order preoperatively?

ESPEN practical guideline: Clinical nutrition in surgery – “Preoperative fasting from midnight is unnecessary in most patients. Patients undergoing surgery, who are considered to have no specific risk of aspiration, shall drink clear fluids until 2 h before anesthesia. Solids shall be allowed until 6 h before anesthesia.”

Pro-Con Debate: 1- vs 2-Hour Fast for Clear Liquids Before Anesthesia in Children.

Editorial: The rationale for the recommendations of the European Pediatric Fasting Guideline – “the authors of the 2021 ESAIC pediatric guideline have found reasons to recommend reductions to the minimum fasting times for infant formula to 4 h, for breast milk to 3 h and for clear fluids to 1 h”.

Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration: Application to Healthy Patients Undergoing Elective Procedures: An Updated Report by the American Society of Anesthesiologists Task Force on Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration

Perioperative fasting in adults and children: guidelines from the European Society of Anaesthesiology

Clear fluids fasting for elective paediatric anaesthesia: The European Society of Anaesthesiology consensus statement – European Journal of Anaesthesiology

Canadian Pediatric Anesthesia Society statement on clear fluid fasting for elective pediatric anesthesia – Canadian Journal of Anesthesia (free)

 

Clinical update on COVID-19 for the emergency and critical care clinician: Medical management.

11 Apr, 2022 | 02:00h | UTC

Clinical update on COVID-19 for the emergency and critical care clinician: Medical management – American Journal of Emergency Medicine

 

Keep the size of your waist to less than half of your height, updated NICE draft guideline recommends.

11 Apr, 2022 | 02:01h | UTC

Keep the size of your waist to less than half of your height, updated NICE draft guideline recommends – National Institute for Health and Care Excellence

Commentaries:

Expert reaction to updated NICE draft guideline on weight management, including the suggestion for people to keep their waist measurement to less than half their height – Science Media Centre

Keep your waist to less than half your height, guidance says – BBC

Draft Guideline: Obesity: identification and classification of overweight and obesity – National Institute for Health and Care Excellence

 

RCT: For adults with HIV, a 4-days-on and 3-days-off treatment strategy is noninferior to standard treatment for maintaining viral suppression.

11 Apr, 2022 | 01:56h | UTC

A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial – The Lancet HIV (link to abstract – $ for full-text)

Commentary: Intermittent Treatment Strategy Is Effective for HIV – Consultant360

 

Commentaries on Twitter

 

Review: Atrial fibrillation.

11 Apr, 2022 | 01:57h | UTC

Atrial fibrillation – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Atrial fibrillation – Nature Reviews Disease Primers (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Twitter promotion is associated with higher citation rates of cardiovascular articles: the ESC Journals Randomized Study.

11 Apr, 2022 | 01:48h | UTC

Twitter promotion is associated with higher citation rates of cardiovascular articles: the ESC Journals Randomized Study – European Society of Cardiology (link to abstract – $ for full-text)

Related:

Randomized Trial: Twitter Promotion Increases Citation Rates of Cardiovascular Articles

Does Tweeting Improve Citations? One-Year Results from the TSSMN Prospective Randomized Trial

A critical review on altmetrics: can we measure the social impact factor?

As scientists take to Twitter, study shows power of ‘visual abstract’ graphics

Riding the Twitter wave: Enthusiasm for the social media platform changed science communication during the pandemic—but will it last?

Optimizing the use of Twitter for research dissemination: The “Three Facts and a Story” randomized-controlled trial.

Perspective: How Twitter is Changing Medical Research

Keeping Up With Cardiology: Old-School Learning Versus the Twittersphere – TCTMD

Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets

Rise of the Tweetorial – Precious Bodily Fluids

Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine

University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC

Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog

What’s your doctor reading? How social media is disrupting medical education – National Post

 

Estimating global, regional, and national daily and cumulative infections with SARS-CoV-2 through Nov 14, 2021: a statistical analysis.

11 Apr, 2022 | 01:58h | UTC

Estimating global, regional, and national daily and cumulative infections with SARS-CoV-2 through Nov 14, 2021: a statistical analysis – The Lancet

Invited Commentary: How to interpret the total number of SARS-CoV-2 infections – The Lancet

 

Commentary on Twitter (thread – click for more)

 

Review: Gastrointestinal post-acute COVID-19 syndrome.

11 Apr, 2022 | 01:49h | UTC

Gastrointestinal post-acute COVID-19 syndrome – Nature Reviews Gastroenterology & Hepatology

 

Commentary on Twitter

 

RCT: Effect of Gram Stain–Guided initial antibiotic therapy on clinical response in patients with ventilator-associated pneumonia.

11 Apr, 2022 | 01:36h | UTC

Effect of Gram Stain–Guided Initial Antibiotic Therapy on Clinical Response in Patients With Ventilator-Associated Pneumonia: The GRACE-VAP Randomized Clinical Trial – JAMA Network Open

Commentary: Can Gram Stains Guide Antibiotics for Pneumonia in Critical Care? – Medscape (free registration required)

 

Commentary on Twitter

 

CoronaVac vaccine is effective in preventing symptomatic and severe COVID-19 in pregnant women in Brazil: a test-negative case-control study.

11 Apr, 2022 | 01:40h | UTC

CoronaVac vaccine is effective in preventing symptomatic and severe COVID-19 in pregnant women in Brazil: a test-negative case-control study – BMC Medicine

 

Clinical care of severe acute respiratory infections – Tool kit (COVID-19 adaptation, update 2022).

11 Apr, 2022 | 01:45h | UTC

Clinical care of severe acute respiratory infections – Tool kit – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

RCT: In critically ill children requiring noninvasive respiratory support following extubation, high-flow nasal cannula therapy was NOT noninferior to CPAP, resulting in increased time to liberation from respiratory support.

8 Apr, 2022 | 11:07h | UTC

Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Following Extubation on Liberation From Respiratory Support in Critically Ill Children: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Selecting Intermediate Respiratory Support Following Extubation in the Pediatric Intensive Care Unit – JAMA (free for a limited period)

News Release: Trial identifies most effective breathing support for children in intensive care – Imperial College London

 

Commentary on Twitter

 

Cohort Study: Use of Phosphodiesterase 5 Inhibitors linked to increased risk of ocular adverse events.

8 Apr, 2022 | 11:04h | UTC

Risk of Ocular Adverse Events Associated With Use of Phosphodiesterase 5 Inhibitors in Men in the US – JAMA Ophthalmology (free for a limited period)

News Release: U.S. insurance claims show strong link between ED medications and vision problems – University of British Columbia

Commentaries:

Phase 4 Studies on Phosphodiesterase 5 Inhibitors – JAMA Ophthalmology (free for a limited period)

Expert reaction to study looking at risk of vision impairment and loss, and use of phosphodiesterase type 5 inhibitors – Science Media Centre

Could Viagra, Cialis Raise Men’s Odds for Eye Trouble? – HealthDay

 

State of the Art Review: Prognostication and shared decision making in neurocritical care.

8 Apr, 2022 | 10:53h | UTC

Prognostication and shared decision making in neurocritical care – The BMJ

 

Commentary on Twitter

 

Risk factors and prognostic implications of diagnosis of cancer within 30 days after an emergency hospital admission (emergency presentation).

8 Apr, 2022 | 10:52h | UTC

Risk factors and prognostic implications of diagnosis of cancer within 30 days after an emergency hospital admission (emergency presentation): an International Cancer Benchmarking Partnership (ICBP) population-based study – The Lancet Oncology

Commentary: Emergency presentations: what are they, and what do they mean for cancer survival? – Cancer Research UK

 

Commentary on Twitter (thread – click for more) – text and images under a Creative Commons Attribution (CC BY 4.0) licence

 

Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.

8 Apr, 2022 | 10:58h | UTC

Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 – The Lancet Gastroenterology & Hepatology

Invited Commentary: Global epidemiology and prevention of colorectal cancer – The Lancet Gastroenterology & Hepatology (free registration required)

 

Opinion | Why the WHO took two years to say COVID is airborne.

8 Apr, 2022 | 10:38h | UTC

Why the WHO took two years to say COVID is airborne – Nature

 

M-A: Thrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia.

8 Apr, 2022 | 10:50h | UTC

Thrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia: A Systematic Review and Meta-Analysis – International Journal of Infectious Diseases

Related:

Case series of Thrombosis with Thrombocytopenia Syndrome after Covid-19 vaccination in the US.

Review: Vaccine-induced immune thrombotic thrombocytopenia.

Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance.

Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.

Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)

 

Long COVID in children: a modified Delphi process.

8 Apr, 2022 | 10:40h | UTC

Long COVID (post-COVID-19 condition) in children: a modified Delphi process – Archives of Disease in Childhood

Related:

First research definition for ‘Long COVID’ in kids and young people formally agreed.

Cohort Study: Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England.

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

Editorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

 

M-A: Diagnostic performance of CO-RADS for Covid-19.

8 Apr, 2022 | 10:31h | UTC

Diagnostic performance of CO-RADS for COVID-19: a systematic review and meta-analysis – European Radiology

Related: CO-RADS – A categorical CT assessment scheme for patients with suspected COVID-19: definition and evaluation – Radiology

 

Putting positive experiences at the center of postnatal care.

8 Apr, 2022 | 10:34h | UTC

Putting positive experiences at the centre of postnatal care – Evidently Cochrane Blog

Original Guideline: WHO recommendations on maternal and newborn care for a positive postnatal experience.

 

Study finds increased risk of pulmonary embolism up to 110 days after COVID-19.

7 Apr, 2022 | 10:06h | UTC

Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: nationwide self-controlled cases series and matched cohort study – The BMJ

News Release: Study finds increased risk of serious blood clots up to six months after COVID-19 – BMJ

Editorial: Thromboembolism and bleeding after covid-19

Commentary: Covid: Blood clot risk higher for six months after having virus – BBC

 

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