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Daily Archives: November 23, 2022

RCT | Low-dose morphine did not significantly reduce the intensity of chronic breathlessness in patients with COPD.

23 Nov, 2022 | 14:09h | UTC

Effect of Regular, Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease: The BEAMS Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Dyspnea—When a Sensation Becomes a Symptom – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Breathlessness in Patients with COPD isn’t Reduced with Daily Morphine – HCP Live

 


KDIGO 2022 Guideline for the prevention, diagnosis, evaluation, and treatment of Hepatitis C in chronic kidney disease.

23 Nov, 2022 | 14:11h | UTC

KDIGO 2022 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease – Kidney International

Executive Summary: KDIGO 2022 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease – Kidney International

News Release: KDIGO Announces Publication of 2022 Hepatitis C in Chronic Kidney Disease Guideline – Kidney Disease: Improving Global Outcomes (KDIGO)

 


Guideline Synopsis | Diagnosis and treatment of infertility in men.

23 Nov, 2022 | 14:08h | UTC

Diagnosis and Treatment of Infertility in Men – JAMA (free for a limited period)

Original Guideline: AUA/ASRM Guideline: Diagnosis and treatment of infertility in men

 


RCT | Treatment of early Lyme Disease with doxycycline for 7 days is noninferior to treatment for 14 days.

23 Nov, 2022 | 14:06h | UTC

Treatment of erythema migrans with doxycycline for 7 days versus 14 days in Slovenia: a randomised open-label non-inferiority trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentary: Shorter Duration of Antibiotics Noninferior for Lyme Disease – JAMA (free for a limited period)

 

Commentary on Twitter

 


RCT | Impact of empagliflozin on decongestion in acute heart failure.

23 Nov, 2022 | 14:04h | UTC

Impact of empagliflozin on decongestion in acute heart failure: the EMPULSE trial – European Heart Journal

Commentary: Empagliflozin in Patients Hospitalized for Acute Heart Failure – EMPULSE – American College of Cardiology

 

Commentary on Twitter

 

Under a https://creativecommons.org/licenses/by-nc/4.0/ license

 


Cohort Study | Race-dependent association of HDL-C levels with incident coronary artery disease.

23 Nov, 2022 | 14:02h | UTC

Race-Dependent Association of High-Density Lipoprotein Cholesterol Levels With Incident Coronary Artery Disease – Journal of the American College of Cardiology

Editorial: HDL-C in Black Adults for ASCVD Risk Calculation: Benefit or Barrier to Achieving Health Equity? – Journal of the American College of Cardiology

News Release: Study challenges “good” cholesterol’s role in universally predicting heart disease risk – National Institutes of Health

Commentary: Study suggests that HDL or ‘good’ cholesterol is less beneficial than previously thought, especially for Black adults – CNN

 


Guideline | Screening and assessment of cancer-related fatigue.

23 Nov, 2022 | 13:58h | UTC

Screening and Assessment of Cancer-Related Fatigue: A Clinical Practice Guideline for Health Care Providers – Physical Therapy

Related: Management of cancer-related fatigue in Taiwan: an evidence-based consensus for screening, assessment and treatment – Japanese Journal of Clinical Oncology

 


RCT | Effects of a physical exercise intervention during vs. after chemotherapy to improve cardiorespiratory fitness.

23 Nov, 2022 | 14:01h | UTC

Optimal Timing of a Physical Exercise Intervention to Improve Cardiorespiratory Fitness: During or After Chemotherapy – JACC: CardioOncology

Editorial: Inclusion of Exercise in Cancer Treatment Planning: When Is the Right Time? – JACC: CardioOncology

Commentary: Exercise Intervention During Chemotherapy Beneficial – HealthDay

 


Cohort Study | Polygenic risk score improves the accuracy of a clinical risk score for coronary artery disease.

23 Nov, 2022 | 13:55h | UTC

Polygenic risk score improves the accuracy of a clinical risk score for coronary artery disease – BMC Medicine

Related:

AHA Scientific Statement | Polygenic risk scores for cardiovascular disease.

Incremental Value of Polygenic Risk Scores in Primary Prevention of Coronary Heart Disease: A Review – JAMA Internal Medicine

Cohort Study | Predictive utility of a validated polygenic risk score for long-term risk of coronary heart disease in young and middle-aged adults.

Cohort Study | Polygenic risk, midlife life’s simple 7, and lifetime risk of stroke.

Cohort Study: A polygenic risk score may improve risk stratification of coronary artery disease.

Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps.

Studies: Little Benefit from Polygenic Risk Score vs. Clinical Risk Score for Predicting Cardiovascular Risk

 

Commentary on Twitter

 


Cohort Study | Prognostic prediction of genotype vs. phenotype in genetic cardiomyopathies.

23 Nov, 2022 | 13:57h | UTC

Prognostic Prediction of Genotype vs Phenotype in Genetic Cardiomyopathies – Journal of the American College of Cardiology

 

Commentary on Twitter

 

Under a Creative Commons license

 


Right heart failure in the ED: approach to diagnosis and management.

23 Nov, 2022 | 13:54h | UTC

Right Heart Failure in the ED: Approach to Diagnosis and Management – emDocs

 


M-A | Acupuncture for low back and/or pelvic pain during pregnancy.

23 Nov, 2022 | 13:52h | UTC

Acupuncture for low back and/or pelvic pain during pregnancy: a systematic review and meta-analysis of randomised controlled trials – BMJ Open

News Release: Acupuncture can relieve lower back/pelvic pain often experienced during pregnancy – BMJ Newsroom

 


Cohort Study | Association of pregnancy characteristics and maternal mortality with amniotic fluid embolism.

23 Nov, 2022 | 13:51h | UTC

Association of Pregnancy Characteristics and Maternal Mortality With Amniotic Fluid Embolism – JAMA Network Open

Invited Commentary: Toward Risk Assessment for Amniotic Fluid Embolisms – JAMA Network Open

 

Commentary on Twitter

 


RCT | Posterior cervical foraminotomy is noninferior to anterior cervical discectomy in patients with cervical radiculopathy.

23 Nov, 2022 | 13:48h | UTC

Noninferiority of Posterior Cervical Foraminotomy vs Anterior Cervical Discectomy With Fusion for Procedural Success and Reduction in Arm Pain Among Patients With Cervical Radiculopathy at 1 Year: The FACET Randomized Clinical Trial – JAMA Neurology (free for a limited period)

 

Commentary on Twitter

 


M-A | Is early laparoscopic cholecystectomy after clearance of common bile duct stones by ERCP superior?

23 Nov, 2022 | 13:44h | UTC

Is early laparoscopic cholecystectomy after clearance of common bile duct stones by endoscopic retrograde cholangiopancreatography superior?: A systematic review and meta-analysis of randomized controlled trials – Medicine

 


M-A | Optimal timing of anterior cruciate ligament reconstruction in patients with anterior cruciate ligament tear.

23 Nov, 2022 | 13:43h | UTC

Optimal Timing of Anterior Cruciate Ligament Reconstruction in Patients With Anterior Cruciate Ligament Tear: A Systematic Review and Meta-analysis – JAMA Network Open

 

Commentary on Twitter

 


SR | Follicular flushing during oocyte retrieval in assisted reproductive techniques.

23 Nov, 2022 | 13:46h | UTC

Follicular flushing during oocyte retrieval in assisted reproductive techniques – Cochrane Library

 

Commentary on Twitter

 


RCT | Simvastatin is ineffective as a disease-modifying treatment for patients with Parkinson’s Disease.

23 Nov, 2022 | 13:42h | UTC

Evaluation of Simvastatin as a Disease-Modifying Treatment for Patients With Parkinson Disease: A Randomized Clinical Trial – JAMA Neurology

Commentary: Simvastatin Ineffective as Disease-Modifying Therapy for Intermediate Parkinson Disease – AJMC

 

Commentary on Twitter

 


RCT | Efficacy and safety of Remibrutinib, a novel BTK inhibitor, for chronic spontaneous urticaria.

23 Nov, 2022 | 13:37h | UTC

Remibrutinib, a novel BTK inhibitor, demonstrates promising efficacy and safety in chronic spontaneous urticaria – The Journal of Allergy and Clinical Immunology

 


SR | Adjunctive therapies in addition to land‐based exercise therapy for osteoarthritis of the hip or knee.

23 Nov, 2022 | 13:40h | UTC

Adjunctive therapies in addition to land‐based exercise therapy for osteoarthritis of the hip or knee – Cochrane Library

 

Commentary on Twitter

 


RCT | Discontinuation vs. continuation of hypertonic saline or dornase alfa in modulator treated people with cystic fibrosis.

23 Nov, 2022 | 13:36h | UTC

Discontinuation versus continuation of hypertonic saline or dornase alfa in modulator treated people with cystic fibrosis (SIMPLIFY): results from two parallel, multicentre, open-label, randomised, controlled, non-inferiority trials – The Lancet Respiratory Medicine (free registration required)

 

Commentary on Twitter

 


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