Daily Archives: October 18, 2022

Retrospective Cohort Study | Trends in the association between diabetes and cardiovascular events, 1994-2019.

18 Oct, 2022 | 12:58h | UTC

Trends in the Association Between Diabetes and Cardiovascular Events, 1994-2019 – JAMA (free for a limited period)

Cluster RCT | Primary prophylaxis with CSFs fails to improve outcomes in patients at intermediate risk for febrile neutropenia.

18 Oct, 2022 | 12:58h | UTC

A Pragmatic Cluster-Randomized Trial of a Standing Order Entry Intervention for Colony-Stimulating Factor Use Among Patients at Intermediate Risk for Febrile Neutropenia – Journal of Clinical Oncology

RCT | Moderate vs. intensive pushing during the active phase of the 2nd stage of labor among nulliparous women with an epidural.

18 Oct, 2022 | 12:56h | UTC

Alternative to intensive management of the active phase of the second stage of labor: a multicenter randomized trial (Phase Active du Second STade trial) among nulliparous women with an epidural – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)

Commentary on Twitter

Alternative to intensive management of the active phase of the second stage of labor: a multicenter randomized trial (PASST trial) among nulliparous women with an epidural – A, Intervention (moderate pushing) group. B, Control (intensive pushing) group. https://t.co/IfdNfWHo57 pic.twitter.com/KmZTYV8eIP

— AJOG (@AJOG_thegray) October 14, 2022

RCT | Two-year effects of Semaglutide in adults with overweight or obesity.

18 Oct, 2022 | 12:53h | UTC

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial – Nature Medicine

Commentary: STEP 5: Sustained semaglutide treatment maintains weight loss – medwire News

RCT: Effect of continued weekly subcutaneous Semaglutide vs. placebo on weight loss maintenance in adults with overweight or obesity

RCT: High dose once a week Semaglutide (2.4 mg) in adults with overweight or obesity, and type 2 diabetes

RCT: Effect of high-dose subcutaneous Semaglutide vs. placebo in adults with overweight or obesity

RCT: Once-weekly, high-dose semaglutide is effective for improving overweight or obesity among non-diabetic adults

Commentary on Twitter

Results from the STEP 5, testing #semaglutide as an adjuct to behavioral interventions in adults with #overweight or #obesity, demonstrate sustained #weightloss over a period of 104 weeks. @ProfBatterhamMD @seanwharton @DrGeorgiaRigas https://t.co/0mBtzhCYID

— Nature Medicine (@NatureMedicine) October 11, 2022

Perspective | The polypill: from concept and evidence to implementation.

18 Oct, 2022 | 12:55h | UTC

The polypill: from concept and evidence to implementation – The Lancet (free registration required)

News Release: The polypill could avoid millions of premature deaths, heart attacks and strokes every year, say leading cardiology experts – McMaster University

#ESCCongress | In patients within 6 months of a myocardial infarction, a polypill containing aspirin, ramipril, and atorvastatin resulted in a lower risk of major adverse cardiovascular events compared to usual care.

#ESCCongress – M-A: Polypills with and without aspirin substantially reduce cardiovascular disease, myocardial infarction, stroke, revascularization, and cardiovascular death in primary cardiovascular disease prevention.

Opinion: A new important study supports wider use of the polypill

#AHA20 – Randomized trial: A polypill comprising statins, multiple blood pressure lowering drugs, and aspirin prevents cardiovascular events among patients at intermediate cardiovascular risk

Perspective: Are Polypills and Population-based Treatment the Next Big Things?

The Polypill Revisited: Why We Still Need Population-Based Approaches in the Precision Medicine Era

Randomized Trial: Polypill for Cardiovascular Disease Prevention in an Underserved Population

Randomized Trial: Effectiveness of Polypill for Primary and Secondary Prevention of Cardiovascular Diseases

Clinical Impact of the Polypill for Cardiovascular Prevention in Latin America: A Consensus Statement of the Inter-American Society of Cardiology – Global Heart

Perspective: The Polypill and the Long Journey to Major Impact

Research: Low-Dose ‘Triple Pill’ Lowers Blood Pressure More Than Usual Care

Guideline | Diagnosis and management of febrile neutropenia in patients with cancer.

18 Oct, 2022 | 12:52h | UTC

The Dutch Working Party on Antibiotic Policy (SWAB) Recommendations for the Diagnosis and Management of Febrile Neutropenia in Patients with Cancer – Infectious Diseases and Therapy

Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update – Journal of Clinical Oncology

Management of sepsis in neutropenic cancer patients: 2018 guidelines from the Infectious Diseases Working Party (AGIHO) and Intensive Care Working Party (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO) – Annals of Hematology

SEOM clinical practice guideline: management and prevention of febrile neutropenia in adults with solid tumors (2018) – Clinical and Translational Oncology

Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)

Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update

Guideline | Sarcopenia: screening, diagnosis, management and prevention.

18 Oct, 2022 | 12:51h | UTC

Singapore Clinical Practice Guidelines For Sarcopenia: Screening, Diagnosis, Management and Prevention – The Journal of Frailty & Aging

Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management – The journal of nutrition, health & aging

Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report – Age and Ageing

Position Statement | Changing the name of diabetes insipidus.

18 Oct, 2022 | 12:50h | UTC

Changing the name of diabetes insipidus: a position statement of The Working Group for Renaming Diabetes Insipidus – Endocrine Connections

Cohort Study | Association between osseointegration of lower extremity amputation and mortality among adults.

18 Oct, 2022 | 12:49h | UTC

Association Between Osseointegration of Lower Extremity Amputation and Mortality Among Adults – JAMA Network Open

Cohort Study | Association of attention-deficit/hyperactivity disorder diagnosis with adolescent quality of life.

18 Oct, 2022 | 12:48h | UTC

Association of Attention-Deficit/Hyperactivity Disorder Diagnosis With Adolescent Quality of Life – JAMA Network Open

Commentary on Twitter

Adolescents with an ADHD diagnosis reported similar quality of life overall and on 3 subdomains but worse outcomes for 5 other aspects of quality of life compared adolescents with similar levels of hyperactive/inattentive behaviors but no ADHD diagnosis. https://t.co/5o0MNfEzjD

— JAMA Network Open (@JAMANetworkOpen) October 13, 2022

Systematic Review | Reconstructive surgery for treating pressure ulcers – little evidence to guide recommendations.

18 Oct, 2022 | 12:46h | UTC

Reconstructive surgery for treating pressure ulcers – Cochrane Library

Post-trial follow-up | Metastasis-directed therapy vs. observation in oligometastatic prostate cancer.

18 Oct, 2022 | 12:47h | UTC

Long-Term Outcomes and Genetic Predictors of Response to Metastasis-Directed Therapy Versus Observation in Oligometastatic Prostate Cancer: Analysis of STOMP and ORIOLE Trials – Journal of Clinical Oncology

Commentary: Metastasis-Directed Therapy for Prostate Cancer Found Beneficial Long-Term – Cancer Therapy Advisor

Commentary on Twitter

? #JCO #RapidCommunication: STOMP & ORIOLE show improved progression-free survival w metastsis driven therapy over observation in oligometastatic #ProstateCancer
? Largest benefit for patients harboring a high-risk mutation #PCSM @matthewdeek @piet_ost https://t.co/OO8kcTVvFT pic.twitter.com/FqxGisz34F

— Journal of Clinical Oncology (@JCO_ASCO) September 19, 2022

Review | Artificial intelligence in perioperative medicine.

18 Oct, 2022 | 12:43h | UTC

Artificial intelligence in perioperative medicine: a narrative review – Korean Journal of Anesthesiology

M-A | Proactive therapeutic drug monitoring vs. conventional management for inflammatory bowel diseases.

18 Oct, 2022 | 12:42h | UTC

Proactive Therapeutic Drug Monitoring Versus Conventional Management for Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis – Gastroenterology

Commentary on Twitter

October's Editor's Essential Reading examines proactive therapeutic drug monitoring versus conventional management for inflammatory bowel diseases @vipuljairath @ChrisMa_YYC https://t.co/kNAia4yowO pic.twitter.com/wfgQSQtM1O

— Gastroenterology (@AGA_Gastro) September 28, 2022