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Daily Archives: September 30, 2022

RCT | Induced hypothermia did not improve survival or functional outcomes after in-hospital cardiac arrest.

30 Sep, 2022 | 12:43h | UTC

Temperature Control After In-Hospital Cardiac Arrest: A Randomized Clinical Trial – Circulation (free for a limited period)

Related:

Hypothermic versus Normothermic Temperature Control after Cardiac Arrest – NEJM Evidence

ERC-ESICM guidelines on temperature control after cardiac arrest in adults – Intensive Care Medicine (if the link is paywalled, try this one)

Target temperature management following cardiac arrest: a systematic review and Bayesian meta-analysis – Critical Care

Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets – Intensive Care Medicine

Targeted Temperature Management for Cardiac Arrest Due to Non-shockable Rhythm: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – Frontiers in Medicine

Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial – JAMA

Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest – New England Journal of Medicine

 

Commentary on Twitter

 

RCT | No benefit from hydrocortisone, vitamin C, and thiamine in adult patients with septic shock.

30 Sep, 2022 | 12:42h | UTC

Early administration of hydrocortisone, vitamin C, and thiamine in adult patients with septic shock: a randomized controlled clinical trial – Critical Care

Related:

Parenteral Vitamin C in Patients with Severe Infection: A Systematic Review – NEJM Evidence

Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit – New England Journal of Medicine

Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis – Intensive Care Medicine

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial – JAMA

 

Perspective/review | Bronchoscopy for diagnosis of ventilator-associated pneumonia.

30 Sep, 2022 | 12:40h | UTC

Bronchoscopy for diagnosis of ventilator-associated pneumonia – Intensive Care Medicine

 

Study | Plaque histology and myocardial disease in sudden coronary death.

30 Sep, 2022 | 12:41h | UTC

Plaque histology and myocardial disease in sudden coronary death: the Fingesture study – European Heart Journal

 

Review | The many faces of cryptogenic organizing pneumonia.

30 Sep, 2022 | 12:40h | UTC

The many faces of cryptogenic organizing pneumonia (COP) – Journal of Clinical Imaging Science

 

Cohort Study | Cardiovascular MRI phenotypes and long-term outcomes in patients with suspected cardiac sarcoidosis.

30 Sep, 2022 | 12:39h | UTC

Cardiovascular Magnetic Resonance Imaging Phenotypes and Long-term Outcomes in Patients With Suspected Cardiac Sarcoidosis – JAMA Cardiology (link to abstract – $ for full-text)

Commentary: Cardiovascular magnetic resonance imaging phenotype with pathology-frequent late gadolinium enhancement associated with high-risk of ventricular arrhythmic and heart failure events – Physician’s Weekly

 

Commentary on Twitter

 

RCT | Self-cut vs. Mesh-Kit titanium-coated polypropylene Mesh for transvaginal treatment of severe pelvic organ prolapse.

30 Sep, 2022 | 12:38h | UTC

Effectiveness of Self-cut vs Mesh-Kit Titanium-Coated Polypropylene Mesh for Transvaginal Treatment of Severe Pelvic Organ ProlapseA Multicenter Randomized Noninferiority Clinical Trial – JAMA Network Open

Commentary: Self-Cut Mesh Noninferior for Pelvic Organ Prolapse Procedure – HealthDay

 

Systematic Review | Randomized clinical trials of machine learning interventions in health care.

30 Sep, 2022 | 12:37h | UTC

Randomized Clinical Trials of Machine Learning Interventions in Health Care: A Systematic Review – JAMA Network Open

 

Current updates in acute traumatic aortic injury: radiologic diagnosis and management.

30 Sep, 2022 | 12:36h | UTC

Current updates in acute traumatic aortic injury: radiologic diagnosis and management – Clinical and Experimental Emergency Medicine

 

RCT | Doxycycline vs. placebo in patients with mild thyroid-associated ophthalmopathy.

30 Sep, 2022 | 12:35h | UTC

Doxycycline vs Placebo at 12 Weeks in Patients With Mild Thyroid-Associated Ophthalmopathy: A Randomized Clinical Trial – JAMA Ophthalmology (free for a limited period)

Invited commentary: Oral Doxycycline for Mild Thyroid Eye Disease – JAMA Opthalmology (free for a limited period)

 

RCT | Adjuvant Nivolumab plus Ipilimumab vs. Nivolumab alone in patients with resected Stage IIIB-D or Stage IV melanoma.

30 Sep, 2022 | 12:33h | UTC

Adjuvant Therapy of Nivolumab Combined With Ipilimumab Versus Nivolumab Alone in Patients With Resected Stage IIIB-D or Stage IV Melanoma (CheckMate 915) – Journal of Clinical Oncology

 

Cohort Study | A clinical calculator for rectal cancer can estimate recurrence after neoadjuvant therapy with or without surgery.

30 Sep, 2022 | 12:34h | UTC

A Dynamic Clinical Calculator for Estimating Conditional Recurrence-Free Survival After Total Neoadjuvant Therapy for Rectal Cancer and Either Surgery or Watch-and-Wait Management – JAMA Network Open

Invited Commentary: A Clinical Calculator in the Era of Nonoperative Management for Rectal Cancer—How Should We Intensify or Deescalate Surveillance? – JAMA Network Open

 

Review | Regional anesthesia and acute perioperative pain management in thoracic surgery.

30 Sep, 2022 | 12:32h | UTC

Regional anesthesia and acute perioperative pain management in thoracic surgery: a narrative review – Journal of Thoracic Disease

 

Review | Iatrogenic opioid withdrawal syndromes in adults in intensive care units.

30 Sep, 2022 | 12:31h | UTC

Iatrogenic opioid withdrawal syndromes in adults in intensive care units: a narrative review – Journal of Thoracic Disease

 

Systematic Review | Increased vs. stable doses of inhaled corticosteroids for exacerbations of asthma in adults and children.

30 Sep, 2022 | 12:30h | UTC

Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children – Cochrane Library

 

Systematic Review | Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.

30 Sep, 2022 | 12:29h | UTC

Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome – Cochrane Library

 

Commentary on Twitter

 

Systematic Review | Impact of residual disease in women with advanced epithelial ovarian cancer after primary surgery.

30 Sep, 2022 | 12:28h | UTC

Impact of residual disease as a prognostic factor for survival in women with advanced epithelial ovarian cancer after primary surgery – Cochrane Library

 

Systematic Review | Laser therapy for treating hypertrophic and keloid scars – not enough evidence to guide recommendations.

30 Sep, 2022 | 12:27h | UTC

Laser therapy for treating hypertrophic and keloid scars – Cochrane Library

Summary: Laser therapy for hypertrophic and keloid scars – Cochrane Library

 

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