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Daily Archives: August 8, 2022

Position statement | Use of albumin in liver cirrhosis.

8 Aug, 2022 | 11:58h | UTC

Position statement on the use of albumin in liver cirrhosis – Annals of Hepatology

 


ACG Clinical Guideline | Gastroparesis.

8 Aug, 2022 | 12:00h | UTC

ACG Clinical Guideline: Gastroparesis – The American Journal of Gastroenterology

Related: United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis – UEG Journal

 


RCT | Effect of once-weekly semaglutide versus thrice-daily insulin aspart, both as add-on to metformin and optimized insulin glargine treatment in participants with type 2 diabetes.

8 Aug, 2022 | 11:56h | UTC

Effect of once-weekly semaglutide versus thrice-daily insulin aspart, both as add-on to metformin and optimized insulin glargine treatment in participants with type 2 diabetes (SUSTAIN 11): A randomized, open-label, multinational, phase 3b trial – Diabetes, Obesity and Metabolism

 


RCT | Antiseptic skin agents to prevent surgical site infection after incisional surgery.

8 Aug, 2022 | 11:54h | UTC

Antiseptic Skin Agents to Prevent Surgical Site Infection After Incisional Surgery: A Randomized, Three-armed Combined Non-inferiority and Superiority Clinical Trial (NEWSkin Prep Study) – Annals of Surgery (link to abstract – $ for full-text)

Related:

Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomised controlled trials – The Lancet Infectious Diseases

Reducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial – The Lancet

 


Two randomized trials found monoclonal antibodies are no better than placebo for Parkinson’s Disease.

8 Aug, 2022 | 11:53h | UTC

Study 1: Trial of Cinpanemab in Early Parkinson’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Study 2: Trial of Prasinezumab in Early-Stage Parkinson’s Diseas – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Monoclonal Antibodies No Better Than Placebo for Early Parkinson Disease – HealthDay

 


Cochrane Collection | Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence.

8 Aug, 2022 | 11:50h | UTC

Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence – Cochrane Library

 


Systematic Review | Impact of low‐dose computed tomography screening on lung cancer‐related mortality.

8 Aug, 2022 | 11:52h | UTC

Impact of low‐dose computed tomography (LDCT) screening on lung cancer‐related mortality – Cochrane Library

Summary: Impact of computed tomography (CT) on lung cancer screening – Cochrane Library

Related:

Association of computed tomography screening with lung cancer stage shift and survival in the United States: quasi-experimental study – The BMJ

Screening for Lung Cancer: CHEST Guideline and Expert Panel Report.

USPSTF Statement: begin screening for lung cancer at age 50 years instead of 55 years for patients at risk

Meta-analysis: Lung cancer screening using low-dose computed tomography reduces lung cancer–specific mortality, albeit with a tradeoff of likely overdiagnosis

 


Is the contemporary care of older persons with acute coronary syndrome evidence-based?

8 Aug, 2022 | 11:48h | UTC

Is the contemporary care of the older persons with acute coronary syndrome evidence-based? – European Heart Journal Open

 

Commentary from the author on Twitter

 


Guidelines for the choice of intravenous fluids for vascular filling in critically ill patients.

8 Aug, 2022 | 11:45h | UTC

Guidelines for the choice of intravenous fluids for vascular filling in critically ill patients, 2021 – Anaesthesia Critical Care & Pain Medicine

 

Commentary on Twitter

 


RCT | Temporary transvenous phrenic nerve stimulation does not benefit difficult-to-wean patients in the ICU.

8 Aug, 2022 | 11:41h | UTC

Randomized Clinical Study of Temporary Transvenous Phrenic Nerve Stimulation in Difficult-to-Wean Patients – American Journal of Respiratory and Critical Care Medicine

Editorial: Transvenous Phrenic Nerve Stimulation: A Novel Therapy Gathering Pace – American Journal of Respiratory and Critical Care Medicine

 


Position Paper | Resuscitative endovascular balloon occlusion of the aorta.

8 Aug, 2022 | 11:43h | UTC

Resuscitative endovascular balloon occlusion of the aorta in Canada: a context-specific position paper from the Canadian Collaborative for Urgent Care Surgery (CANUCS) – Canadian Journal of Surgery

 


Systematic Review | Evaluating the diagnostic pathway for acute anterior cruciate ligament injuries in trauma centers.

8 Aug, 2022 | 11:40h | UTC

Evaluating the diagnostic pathway for acute ACL injuries in trauma centres: a systematic review – BMC Musculoskeletal Disorders

 


M-A | Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards.

8 Aug, 2022 | 11:37h | UTC

Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards: systematic review and meta-analysis – Diabetes Research and Clinical Practice

 


Statistical significance and its critics: practicing damaging science, or damaging scientific practice?

8 Aug, 2022 | 11:35h | UTC

Statistical significance and its critics: practicing damaging science, or damaging scientific practice? – Synthese

Related:

Bayesian interpretation of p values in clinical trials – BMJ Evidence-Based Medicine

Scientists rise up against statistical significance – Nature

It’s time to talk about ditching statistical significance – Nature

PulmCrit- .050 shades of grey in p-value cutoffs

Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations – European Journal of Epidemiology

What a nerdy debate about p-values shows about science — and how to fix it – VOX

Big names in statistics want to shake up much-maligned P value – Nature News

‘One-size-fits-all’ threshold for P values under fire – Nature News

Statisticians issue warning over misuse of P values – Nature News

Understanding common misconceptions about p-values – The 20% Statistician

The clinician’s guide to p values, confidence intervals, and magnitude of effects – Eye (if the link is paywalled, try this one)

 


RCT | Partial breast irradiation vs. whole breast irradiation for early breast cancer.

8 Aug, 2022 | 11:36h | UTC

Partial Breast Irradiation Versus Whole Breast Irradiation for Early Breast Cancer Patients in a Randomized Phase III Trial: The Danish Breast Cancer Group Partial Breast Irradiation Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)

 


RCT | Balloon pulmonary angioplasty versus riociguat for the treatment of inoperable chronic thromboembolic pulmonary hypertension.

8 Aug, 2022 | 11:30h | UTC

Balloon pulmonary angioplasty versus riociguat for the treatment of inoperable chronic thromboembolic pulmonary hypertension (RACE): a multicentre, phase 3, open-label, randomised controlled trial and ancillary follow-up study – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 


M-A | The efficacy and safety of paravertebral block for postoperative analgesia in renal surgery.

8 Aug, 2022 | 11:32h | UTC

The efficacy and safety of paravertebral block for postoperative analgesia in renal surgery: A systematic review and meta-analysis of randomized controlled trials – Frontiers in Surgery

 


Systematic Review | Risk of adverse pregnancy outcomes prior to the onset of an autoimmune rheumatic disease.

8 Aug, 2022 | 11:28h | UTC

Risk of adverse pregnancy outcomes prior to the onset of an autoimmune rheumatic disease: a systematic review – Rheumatology

 


Systematic Review | Hydrogel dressings for venous leg ulcers.

8 Aug, 2022 | 11:27h | UTC

Hydrogel dressings for venous leg ulcers – Cochrane Library

Summary: Hydrogel dressings for venous leg ulcers – Cochrane Library

 


Systematic Review | Action observation for upper limb rehabilitation after stroke.

8 Aug, 2022 | 11:26h | UTC

Action observation for upper limb rehabilitation after stroke – Cochrane Library

 


Retrospective Cohort Study | Retrospective evaluation of ophthalmological and neurological outcomes for infants born before 24 weeks gestational age.

8 Aug, 2022 | 11:24h | UTC

Retrospective evaluation of ophthalmological and neurological outcomes for infants born before 24 weeks gestational age in a Swedish cohort – BMJ Open

 


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