Daily Archives: August 4, 2022 | LinksMedicus Free Medical News & Perspectives

Phase 1 Study | Low-dose subcutaneous or intravenous monoclonal antibody can prevent malaria in a human challenge model.

4 Aug, 2022 | 14:45h | UTC

Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria – New England Journal of Medicine

Editorial: Monoclonal Antibodies for Malaria – New England Journal of Medicine

Standardized definitions for bioprosthetic valve dysfunction following aortic or mitral valve replacement.

4 Aug, 2022 | 14:35h | UTC

Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement: JACC State-of-the-Art Review – Journal of the American College of Cardiology

Commentary on Twitter

Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement: JACC State-of-the-Art Reviewhttps://t.co/xaUpRTD0rd @JACCJournals pic.twitter.com/IINRrOtXRY

— Giuseppe Biondi-Zoccai (@gbiondizoccai) July 26, 2022

Under a http://creativecommons.org/licenses/by/4.0/ license

Viewpoint | Deimplementation of low-value care in surgery.

4 Aug, 2022 | 14:43h | UTC

Deimplementation of Low-Value Care in Surgery – JAMA Surgery (free for a limited period)

Enhancing primary stroke prevention: a combination approach.

4 Aug, 2022 | 14:42h | UTC

Enhancing primary stroke prevention: a combination approach – The Lancet Public Health

Commentary on Twitter

Primary #stroke #prevention strategies target behavioural and pharmacological approaches. Also need to manage structural factors that support or hinder prevention actions and behaviours. @StrokeImperial @Simzy_x @Tsering_ @SomaBanerjee73 @CFCFoundation
https://t.co/vyyhhfeg7Y pic.twitter.com/kqwF9DROG2

— Joseph Kwan, MD ?? (@drjkwan) July 31, 2022

Under a Creative Commons Attribution (CC BY 4.0) license

Case-Control Study | Outpatient oral macrolide use is associated with increased risk of sensorineural hearing loss in children, adolescents, and young adults.

4 Aug, 2022 | 14:29h | UTC

Association of Outpatient Oral Macrolide Use With Sensorineural Hearing Loss in Children, Adolescents, and Young Adults – JAMA Otolaryngology-Head & Neck Surgery (link to abstract – $ for full-text)

Commentary: Kids’ Hearing Loss Associated With Common Antibiotics — Children and teens with sensorineural hearing loss more often macrolide users – MedPage Today (free registration required)

RCT | 72 weeks post-partum follow-up of dolutegravir versus efavirenz initiated in late pregnancy.

4 Aug, 2022 | 14:33h | UTC

72 weeks post-partum follow-up of dolutegravir versus efavirenz initiated in late pregnancy (DolPHIN-2): an open-label, randomised controlled study – The Lancet HIV

WHO Recommends Dolutegravir as Preferred HIV Treatment Option in All Populations

Week 96 results from a RCT: Efficacy and safety of dolutegravir or darunavir combined with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection.

RCT: Efficacy and safety of switching to the 2-drug regimen Dolutegravir/Lamivudine vs. continuing a 3- or 4-Drug regimen for maintaining virologic suppression in adults living with HIV-1.

RCT: Low-cost, easy to take antiretroviral treatment based on Dolutegravir as first- or second-Line therapy found to be non-inferior to standard care for treating HIV-1 infection in children.

RCT: Dolutegravir or Darunavir in combination with Zidovudine or Tenofovir to treat HIV.

Randomized controlled trial compared three antiretroviral regimens started in pregnant women with HIV

Randomized Trial: Switching to Dolutegravir/Lamivudine Two-Drug Regimen Noninferior to Continuing a Tenofovir Alafenamide–Based Three- or Four-Drug Regimen for Maintenance of Virologic Suppression in Adults With HIV-1

Cohort Study | The risk of opioid overdose is increased with concomitant use of oxycodone and selective serotonin reuptake inhibitors that are inhibitors of oxycodone metabolism.

4 Aug, 2022 | 14:27h | UTC

Risk of Opioid Overdose Associated With Concomitant Use of Oxycodone and Selective Serotonin Reuptake Inhibitors – JAMA Network Open

Commentary from the author: Taking certain opioids while on commonly prescribed antidepressants may increase the risk of overdose – The Conversation

Commentary on Twitter

This cohort study found that concomitant use of oxycodone with potent CYP2D6-inhibiting serotonin reuptake inhibitors (SSRIs, eg. fluoxetine or paroxetine) is associated with an increased risk of overdose. https://t.co/Eol89RHWAu

— JAMA Network Open (@JAMANetworkOpen) February 24, 2022

In a cohort study with a median follow‐up of 23.2 years, both very low and very high LDL‐C levels are associated with increased risk of cardiovascular mortality in the general population.

4 Aug, 2022 | 14:25h | UTC

Association of Low‐Density Lipoprotein Cholesterol Levels with More than 20‐Year Risk of Cardiovascular and All‐Cause Mortality in the General Population – Journal of the American Heart Association

M-A | Efficacy of Doxycycline for mild-to-moderate community-acquired pneumonia in adults.

4 Aug, 2022 | 14:17h | UTC

Efficacy of Doxycycline for Mild-to-moderate Community-acquired Pneumonia in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials – Clinical Infectious Diseases (link to abstract – $ for full-text)

Commentary on Twitter

?⚡⚡Systematic Review and Meta-analysis of Randomized Controlled Trials @CIDJournal
Efficacy of Doxycycline for Mild-to-moderate CAP in Adults
The efficacy of doxycycline was comparable to macrolides or fluoroquinolones in mild-moderate CAP #IDTwitter https://t.co/L7UBBUc4Dm

— Antibiotic Steward Bassam Ghanem?⚡ (@ABsteward) July 29, 2022