Daily Archives: July 21, 2022
RCT | In patients undergoing cardiac surgery with cardiopulmonary bypass, using a 4% albumin solution for volume expansion did not reduce adverse events compared to ringer acetate.
21 Jul, 2022 | 13:32h | UTCEffect of 4% Albumin Solution vs Ringer Acetate on Major Adverse Events in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Albumin vs Crystalloid Fluid for Resuscitation in Cardiac Surgery: New Evidence and Arguments in the Timeless Debate – JAMA (free for a limited period)
Commentary: Trial does not support albumin as primer, volume replacement solution in CABG – Healio (free registration required)
Commentary on Twitter
#OriginalInvestigation: Clinical trial findings do not support the use of 4% albumin solution in cardiac surgery with cardiopulmonary bypass. @EeroJPesonen https://t.co/uyWQRdxfuJ pic.twitter.com/RJ5M9NBb9x
— JAMA (@JAMA_current) July 19, 2022
Comprehensive review finds little evidence that depression is caused by an imbalance of serotonin in the brain.
21 Jul, 2022 | 13:29h | UTCNews Release: No evidence that depression is caused by low serotonin levels, finds comprehensive review – University College London
Commentary from the authors: Depression is probably not caused by a chemical imbalance in the brain – new study – The Conversation
Other commentaries:
Expert reaction to a review paper on the ‘serotonin theory of depression’ – Science Media Centre
Little evidence that chemical imbalance causes depression, UCL scientists find – The Guardian
Cohort Study | Effectiveness of the Pfizer vaccine against Omicron in children 5 to 11 years of age.
21 Jul, 2022 | 13:28h | UTC
Single-arm phase 1–2 trial of AAVS3 gene therapy in patients with Hemophilia B.
21 Jul, 2022 | 13:23h | UTCPhase 1–2 Trial of AAVS3 Gene Therapy in Patients with Hemophilia B – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Novel gene therapy could reduce bleeding risk for hemophilia patients – University College London
Commentary: Hemophilia B Gene Therapy Produces Durable Response for 90% of Participants – AJMC
Commentary on Twitter
Nine of 10 patients with hemophilia B who received a liver-directed adeno-associated viral vector containing a hyperactive variant of factor IX maintained factor IX activity for up to 42 months. Thrombosis developed in 1 patient. https://t.co/yId8HWS1u2 pic.twitter.com/CdDeizSMK6
— NEJM (@NEJM) July 20, 2022
RCT | Pembrolizumab plus chemotherapy in advanced triple-negative breast cancer.
21 Jul, 2022 | 13:25h | UTCPembrolizumab plus Chemotherapy in Advanced Triple-Negative Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Among patients with triple-negative breast cancer and high expression of PD-L1, pembrolizumab plus chemotherapy resulted in longer overall survival than chemotherapy alone. https://t.co/5urffgHdFb pic.twitter.com/2GlmJuYZJz
— NEJM (@NEJM) July 20, 2022
Analysis | Fiber intake for optimal health: how can healthcare professionals support people to reach dietary recommendations?
21 Jul, 2022 | 13:17h | UTC
Retrospective cohort study | Impact of ethnicity on the accuracy of measurements of oxygen saturations.
21 Jul, 2022 | 13:15h | UTCRelated:
Racial Bias in Pulse Oximetry Measurement – New England Journal of Medicine
FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias – STAT
Pulse Oximeter Accuracy and Limitations: FDA Safety Communication – U.S. Food & Drug Administration
With monkeypox spreading globally, many experts believe the virus can’t be contained.
21 Jul, 2022 | 13:12h | UTCWith monkeypox spreading globally, many experts believe the virus can’t be contained – STAT
Related:
Diagnosis, Prevention, and Treatment of Monkeypox – JAMA
7 of your most pressing monkeypox vaccine questions, answered – Vox
How contagious is monkeypox—and should you get a vaccine? Here’s the latest. – National Geographic
Prevention and Treatment of Monkeypox – Drugs
Monkeypox soars in Europe, with more than 4,000 cases – CIDRAP
No room for complacency – World Health Organization
Multi-country monkeypox outbreak: situation update – World Health Organization
Monkeypox Genital Lesions – New England Journal of Medicine
Monkeypox vaccination begins — can the global outbreaks be contained? – Nature
Incubation period for monkeypox: Estimates from the Netherlands.
‘Discriminatory and stigmatizing’: Scientists push to rename monkeypox viruses – STAT
Rename monkeypox strains to remove geographic stigma, researchers say – Science
2022 Monkeypox and Orthopoxvirus Outbreak Global Map – Centers for Disease Control and Prevention
As monkeypox threat grows, scientists debate best vaccine strategy – Science
Monkeypox is a new global threat. African scientists know what the world is up against – Science
Experts highlight sexual aspect of monkeypox spread – CIDRAP
What to Know About Monkeypox – JAMA
Multi-country monkeypox outbreak in non-endemic countries: Update – World Health Organization
Monkeypox outbreaks: 4 key questions researchers have – Nature
Study reports first use of antivirals in monkeypox patients – Lancet
Surveillance, case investigation and contact tracing for Monkeypox – World Health Organization
Laboratory testing for the monkeypox virus: Interim guidance – World Health Organization
A Novel International Monkeypox Outbreak – Annals of Internal Medicine
EU health agency warns monkeypox could become endemic in Europe if outbreak continues – STAT
Monkeypox cases increase across Europe, North America – CIDRAP
Multi-country monkeypox outbreak in non-endemic countries – World Health Organization
Monkeypox goes global: why scientists are on alert – Nature
Monkeypox: What do we know about the outbreaks in Europe and North America? – The BMJ
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – STAT
Monkeypox: Time to worry or one to ignore? – BBC
UK, Spain, Portugal report more monkeypox cases – CIDRAP
U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak – STAT
Monkeypox – United Kingdom of Great Britain and Northern Ireland – World Health Organization
Monkeypox cases confirmed in England – latest updates – UK Health Security Agency
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – Health Policy Watch
European outbreak of monkeypox: what you need to know – The Conversation
Rare monkeypox outbreak in U.K., Europe and U.S.: What is it and should we worry – NPR
Monkeypox cases under investigation in Canada as outbreak spreads in Europe, U.S. – CBC News
Systematic Review | Type of anesthesia for acute ischemic stroke endovascular treatment.
21 Jul, 2022 | 13:06h | UTCType of anaesthesia for acute ischaemic stroke endovascular treatment – Cochrane Library
DCRM Multispecialty Practice Recommendations for the management of diabetes, cardiorenal, and metabolic diseases.
21 Jul, 2022 | 13:11h | UTC
RCT | Effect of Nintedanib on progression of systemic sclerosis-associated interstitial lung disease over 100 weeks.
21 Jul, 2022 | 13:03h | UTCCommentary: Durable Efficacy for Drug Preventing Lung Progression in Systemic Sclerosis — One-year results sustained over another 48 weeks – MedPage Today (free registration required)
Consensus Recommendations | Screening, diagnosis and management of sarcopenia and frailty in hospitalized older adults.
21 Jul, 2022 | 13:08h | UTC
Evidence Review | Exercise training for adults having maintenance dialysis.
21 Jul, 2022 | 13:04h | UTCExercise training for adults having maintenance dialysis – Evidently Cochrane
Original Study: Exercise training for adults undergoing maintenance dialysis – Cochrane Library
RCT | Laparoscopic vs. open distal gastrectomy for locally advanced gastric cancer.
21 Jul, 2022 | 13:00h | UTCSee also: Visual Abstract
Commentary: Laparoscopy Noninferior to Open Surgery in Locally Advanced Gastric Cancer – MedPage Today (free registration required)
Related:
Laparoscopic vs Open Distal Gastrectomy for Locally Advanced Gastric Cancer: Five-Year Outcomes From the CLASS-01 Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)
Morbidity and Mortality of Laparoscopic vs Open Total Gastrectomy for Clinical Stage I Gastric Cancer: The CLASS02 Multicenter Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)
Survival outcomes after laparoscopy-assisted distal gastrectomy versus open distal gastrectomy with nodal dissection for clinical stage IA or IB gastric cancer (JCOG0912): a multicentre, non-inferiority, phase 3 randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Effect of Laparoscopic Distal Gastrectomy vs Open Distal Gastrectomy on Long-term Survival Among Patients With Stage I Gastric Cancer: The KLASS-01 Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)
Review | Clinical implications, evaluation, and management of hyponatremia in cirrhosis.
21 Jul, 2022 | 12:53h | UTC
M-A | Loop diuretics in adult intensive care patients with fluid overload.
21 Jul, 2022 | 12:56h | UTC
Retrospective Cohort Study | Major adverse cardiovascular events in patients with renal cell carcinoma treated with targeted therapies.
21 Jul, 2022 | 12:54h | UTC
Psychological violence in dating relationships among adolescents | A systematic review and meta-analysis of prevention programs.
21 Jul, 2022 | 12:47h | UTC
M-A | Effects of transcranial direct current stimulation on poststroke dysphagia.
21 Jul, 2022 | 12:49h | UTC
Review | Fatigue in cirrhosis.
21 Jul, 2022 | 12:52h | UTCFatigue in Cirrhosis – Journal of Clinical and Experimental Hepatology
RCT | Endoscopic papillary large balloon dilation reduces further recurrence in patients with recurrent common bile duct stones.
21 Jul, 2022 | 12:46h | UTCEndoscopic Papillary Large Balloon Dilation Reduces Further Recurrence in Patients With Recurrent Common Bile Duct Stones: A Randomized Controlled Trial – American Journal of Gastroenterology (link to abstract – $ for full-text)
Systematic Review | Patient-level interventions to reduce alcohol-related harms in low- and middle-income countries.
21 Jul, 2022 | 12:43h | UTC
Commentary on Twitter
1/2
A very productive course on systematic reviews at @DukeGHI resulted in a study that summarized findings on the effectiveness of interventions to reduce alcohol-related harms in LMICs. Check it out!
➡️https://t.co/LtQhCx6Kh3 pic.twitter.com/WksDicEqpy— GEMINI Research Center (@GEMINI_Research) April 12, 2022
RCT | Using a smartphone application maintains physical activity following pulmonary rehabilitation in patients with COPD.
21 Jul, 2022 | 12:45h | UTC
Review | Therapeutic advances in alcohol-associated hepatitis.
21 Jul, 2022 | 12:36h | UTCTherapeutic advances in alcohol-associated hepatitis – Journal of Hepatology
Commentary on Twitter
Therapeutic advances in #AlcoholAassociatedHepatitis
How to personalise biomarkers & therapies for AH patients❓
By @GSzaboMD, @MarkThursz & @Dr_Vijay_Shah
Full text here?https://t.co/XubWfBCuis
Part of #BreakthroughsInHepatology
➡️https://t.co/QHvXVi5lG8#LiverTwitter pic.twitter.com/dEApFM6JIj— Journal of Hepatology (@JHepatology) June 23, 2022
M-A | Effectiveness of interventions to improve medication adherence in adults with depressive disorders.
21 Jul, 2022 | 12:33h | UTC