Daily Archives: May 25, 2022 | LinksMedicus Free Medical News & Perspectives

Measuring the availability of human resources for health and its relationship to universal health coverage for 204 countries and territories from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019.

25 May, 2022 | 11:51h | UTC

Measuring the availability of human resources for health and its relationship to universal health coverage for 204 countries and territories from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019 – The Lancet

News Release: Worldwide shortage of health workers threatens effective health coverage – Institute for Health Metrics and Evaluation

Commentaries on Twitter

Considerable expansion of the world's health workforce is needed to reach targets for #UHC—new #GBDStudy estimates a shortage of 43 million health workers in 2019.

More: https://t.co/FknaY0Onzl @IHME_UW pic.twitter.com/sydiV2Ze1e

— The Lancet (@TheLancet) May 24, 2022

? IHME #GBDStudy reveals that more than 43 million additional health workers are needed globally and ensure all people worldwide have access to the health services they need. #HRH #UHC
Read study here »https://t.co/op3iTNZHtJ pic.twitter.com/LkU3V5tFFN

— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) May 23, 2022

RCT: The addition of Metformin to standard therapy did not improve outcomes in patients with breast cancer.

25 May, 2022 | 11:49h | UTC

Effect of Metformin vs Placebo on Invasive Disease–Free Survival in Patients With Breast Cancer: The MA.32 Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Who Will Benefit From Metformin? – JAMA Oncology

News Release: Common diabetes drug not effective against early-stage breast cancer, landmark trial reveals – Lunenfeld-Tanenbaum Research Institute

Retrospective Cohort Study: The incidence of ischemic stroke in patients with asymptomatic severe carotid stenosis (70% to 99%) without surgical intervention was 4.7% over 5 years.

25 May, 2022 | 11:48h | UTC

Incidence of Ischemic Stroke in Patients With Asymptomatic Severe Carotid Stenosis Without Surgical Intervention – JAMA (free for a limited period)

News Release: Low stroke risk in patients with very narrowed neck arteries – Kaiser Permanente

USPSTF Recommendation Statement: The current evidence is insufficient to make a recommendation about screening for impaired visual acuity in older adults.

25 May, 2022 | 11:44h | UTC

Screening for Impaired Visual Acuity in Older Adults: US Preventive Services Task Force Recommendation Statement – JAMA

Editorials:

Visual Acuity Screening in Older Adults – JAMA Ophthalmology

Screening for Impaired Visual Acuity in Older Adults – JAMA

Vision Impairment Has Implications for Aging and Health Outcomes, Beyond Ophthalmology – JAMA Network Open

Evidence Report: Screening for Impaired Visual Acuity in Older Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Patient Page: Screening for Impaired Visual Acuity in Older Adults – JAMA

Author Interview: USPSTF Recommendations: Screening for Primary Open-Angle Glaucoma and Screening for Impaired Visual Acuity in Older Adults – JAMA

USPSTF Recommendation Statement: The current evidence is insufficient to make a recommendation about screening for primary open-angle glaucoma in adults.

25 May, 2022 | 11:46h | UTC

Screening for Primary Open-Angle Glaucoma: US Preventive Services Task Force Recommendation Statement – JAMA

Editorials:

Identifying Glaucoma in Primary Care Offices – JAMA Ophthalmology

Screening for Glaucoma – JAMA

Evidence Report: Screening for Glaucoma in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Patient Page: Screening for Primary Open-Angle Glaucoma – JAMA

Author Interview: USPSTF Recommendations: Screening for Primary Open-Angle Glaucoma and Screening for Impaired Visual Acuity in Older Adults

Effectiveness of CoronaVac in children 3 to 5 years during the SARS-CoV-2 Omicron outbreak in Chile.

25 May, 2022 | 11:42h | UTC

Effectiveness of CoronaVac in children 3 to 5 years during the SARS-CoV-2 Omicron outbreak in Chile – Nature Medicine

RCT: Baricitinib vs. dexamethasone for adults hospitalized with COVID-19.

25 May, 2022 | 11:38h | UTC

Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial – The Lancet Respiratory Medicine

Commentary on Twitter

?Just Out
ACTT-4 Trial?First Double Placebo-Controlled Double-Blind Randomized-Stratified Head-to-Head#DEXAMETHASONE vs #BARICITINIB for hospitalized pts w/#COVID19 Low/High-Flow/NIV
Relevant?Patient Care/Public Health/Guidelines
Our results
?https://t.co/4Tmue7HK7V
?1/4 pic.twitter.com/aF1Y7BAdu3

— Andre Kalil, MD MPH (@DrAndreKalil) May 24, 2022

Joint consensus guidelines on the diagnosis and management of eosinophilic esophagitis in children and adults.

25 May, 2022 | 11:32h | UTC

British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelines on the diagnosis and management of eosinophilic oesophagitis in children and adults – Gut

Short term, relative effectiveness of four doses versus three doses of BNT162b2 vaccine in people aged 60 years and older in Israel: retrospective, test negative, case-control study.

25 May, 2022 | 11:34h | UTC

Short term, relative effectiveness of four doses versus three doses of BNT162b2 vaccine in people aged 60 years and older in Israel: retrospective, test negative, case-control study – The BMJ

Related recommendations:

Covid-19: Second boosters may benefit at-risk groups but have “minimal” impact for others, says WHO – The BMJ

COVID-19: Joint statement from ECDC and EMA on the administration of a fourth dose of mRNA vaccines –
European Centre for Disease Prevention and Control

Coronavirus (COVID-19) Update: FDA Authorizes Second Booster Dose of Two COVID-19 Vaccines for Older and Immunocompromised Individuals – U.S. Food & Drug Administration

Guidance on contrast associated acute kidney injury.

25 May, 2022 | 11:30h | UTC

Canadian Association of Radiologists Guidance on Contrast Associated Acute Kidney Injury – Canadian Association of Radiologists Journal

Use of Intravenous Iodinated Contrast Media in Patients with Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation – Radiology

SIRM-SIN-AIOM: appropriateness criteria for evaluation and prevention of renal damage in the patient undergoing contrast medium examinations—consensus statements from Italian College of Radiology (SIRM), Italian College of Nephrology (SIN) and Italian Association of Medical Oncology (AIOM) – La radiologia medica

Association of Intravenous Radiocontrast With Kidney Function: A Regression Discontinuity Analysis – JAMA Internal Medicine

Takotsubo Syndrome: Pathophysiology, emerging concepts and clinical implications.

25 May, 2022 | 11:28h | UTC

Takotsubo Syndrome: Pathophysiology, Emerging Concepts and Clinical Implications – Circulation

Commentary on Twitter

#InDepth: Explore the pathophysiology, clinical implications and emerging concepts in #Takotsubo Syndrome @dana_dawson16 #AHAJournals https://t.co/sVXBZB02bT pic.twitter.com/tfZIMt00zG

— Circulation (@CircAHA) March 30, 2022

M-A: Comparison of ultra-low, low and high concentration local anesthetic for labor epidural analgesia.

25 May, 2022 | 11:17h | UTC

Comparison of ultra-low, low and high concentration local anaesthetic for labour epidural analgesia: a systematic review and network meta-analysis – Anaesthesia

Opinion: Improving efficiency in medical diagnosis.

25 May, 2022 | 11:19h | UTC

Improving Efficiency in Medical Diagnosis – JAMA (free for a limited period)

Cohort Study: In patients with coronary artery disease, very high HDL-C levels are paradoxically associated with higher cardiovascular and all-cause mortality.

25 May, 2022 | 11:15h | UTC

Association Between High-Density Lipoprotein Cholesterol Levels and Adverse Cardiovascular Outcomes in High-risk Populations – JAMA Cardiology (link to abstract – $ for full-text)

Preventing birth defects, saving lives, and promoting health equity: an urgent call to action for universal mandatory food fortification with folic acid.

25 May, 2022 | 11:12h | UTC

Preventing birth defects, saving lives, and promoting health equity: an urgent call to action for universal mandatory food fortification with folic acid – The Lancet Global Health

News Release: Researchers Urge for a World Health Assembly Resolution on Universal Mandatory Folic Acid Fortification to Prevent Disabilities and Deaths in Infants Worldwide – Emory University

Study Commentary: Cerebrospinal fluid biomarkers for depression.

25 May, 2022 | 10:59h | UTC

Cerebrospinal fluid biomarkers for depression – The Mental Elf

Original Study: Cerebrospinal Fluid Biomarkers in Patients With Unipolar Depression Compared With Healthy Control Individuals: A Systematic Review and Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)

Commentary on Twitter

Comprehensive systematic review and meta-analysis of all cerebrospinal fluid studies in #depression investigating contrast to healthy controls (165 biomarkers from 97 studies) pointing at several biological mechanisms and future directions. https://t.co/gcjFBjYJhi @MichaelBenros

— JAMA Psychiatry (@JAMAPsych) April 25, 2022

Cohort Study: Analysis of neuropsychiatric diagnoses after montelukast initiation.

25 May, 2022 | 11:05h | UTC

Analysis of Neuropsychiatric Diagnoses After Montelukast Initiation – JAMA Network Open

FDA requires Boxed Warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair); advises restricting use for allergic rhinitis – U.S. Food & Drug Administration

Adverse drug reactions of montelukast in children and adults – Pharmacology Research & Perspectives

Commentary on Twitter

This cohort study of patients with asthma or allergic rhinitis found montelukast use is associated with higher odds of neuropsychiatric outcomes, including anxiety and insomnia. https://t.co/HAzcADsHZc

— JAMA Network Open (@JAMANetworkOpen) May 24, 2022

RCT: Everolimus is not beneficial when added to adjuvant endocrine therapy in patients with high-risk hormone receptor–positive, human epidermal growth factor receptor 2–negative primary breast cancer.

25 May, 2022 | 10:57h | UTC

Everolimus Added to Adjuvant Endocrine Therapy in Patients With High-Risk Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Primary Breast Cancer – Journal of Clinical Oncology

Commentaries on Twitter

Previously presented @myESMO VP, the #UNIRAD RCT of adjuvant everolimus in high-risk EBC is now published on @JCO_ASCO. Trial stopped for futility: everolimus didn’t improve DFS & was poorly tolerated. Large research effort answering an important question.https://t.co/wmYLWpDWTC

— Paolo Tarantino (@PTarantinoMD) May 24, 2022

Everolimus added to adjuvant ET fails to improve DFS in patients with high-risk HR+ve, HER2 neg primary breast cancer; poorly tolerated -53.4% discontinuation ratehttps://t.co/lmq2jhbhCO

— K Pavithran (@drkpavithran) May 24, 2022

Cohort Study: Risk of venous thromboembolism in men with prostate cancer compared with men in the general population.

25 May, 2022 | 11:01h | UTC

Risk of venous thromboembolism in men with prostate cancer compared with men in the general population: a nationwide population-based cohort study in Sweden – BMJ Open

News Release: Men with prostate cancer have a higher risk of serious blood clots – BMJ

Commentary on Twitter

Men with prostate cancer have a 50% higher risk of developing venous thrombosis during the 5 years following their cancer diagnosishttps://t.co/RrYAB5lSrb pic.twitter.com/VGMI7GILgE

— K Pavithran (@drkpavithran) May 24, 2022

Under a http://creativecommons.org/licenses/by-nc/4.0/ license

Review: Frequent premature atrial contractions as a signaling marker of atrial cardiomyopathy, incident atrial fibrillation, and stroke.

25 May, 2022 | 10:50h | UTC

Frequent premature atrial contractions as a signalling marker of atrial cardiomyopathy, incident atrial fibrillation, and stroke – Cardiovascular Research

Commentary on Twitter

We got the beat?

Must-read Review of premature atrial contractions & their use as a signalling marker to assess the risk of #AtrialFibrillation & #stroke https://t.co/Vg4kMzGSX1 @CVR_TomaszGuzik @DrMikeDrozd @glenpyle #AFib #cardiomyopathy #CardiovascularResearch pic.twitter.com/S8RgiAiQ3T

— European Society of Cardiology Journals (@ESC_Journals) May 20, 2022

Under a https://creativecommons.org/licenses/by/4.0/ license

RCT: Effect of Denosumab added to 2 different nab-paclitaxel regimens as neoadjuvant therapy in patients with primary breast cancer.

25 May, 2022 | 10:54h | UTC

Effect of Denosumab Added to 2 Different nab-Paclitaxel Regimens as Neoadjuvant Therapy in Patients With Primary Breast Cancer: The GeparX 2 × 2 Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)

Commentary on Twitter

In a randomized clinical trial in 780 pts with #breastcancer, addition of denosumab to anthracycline/taxane-containing neoadjuvant chemotherapy with two different nab-paclitaxel schedules did not increase the pCR rate (41% vs 43% without denosumab): https://t.co/gPu6hrSp7z #bcsm

— NatureRevClinOncol (@NatRevClinOncol) May 24, 2022

Cohort Study: Mortality among patients with early-onset atrial fibrillation and rare variants in cardiomyopathy and arrhythmia genes.

25 May, 2022 | 10:52h | UTC

Mortality Among Patients With Early-Onset Atrial Fibrillation and Rare Variants in Cardiomyopathy and Arrhythmia Genes – JAMA Cardiology

Commentaries:

Mortality in Early-Onset AF and Rare Variants in Cardiomyopathy and Arrhythmia Genes – American College of Cardiology

Disease-Associated Cardiomyopathy Variants May Increase Mortality Risk in Early-Onset AF – HCP Live

Commentary on Twitter

In early-onset atrial fibrillation (diagnosed before age 66), genetic testing revealed cardiomyopathy and arrhythmia rare variants were associated with a higher risk of death in long term follow up. https://t.co/a1C9w1tZm7 #atrialfibrillation #genetictesting

— JAMA Cardiology (@JAMACardio) May 13, 2022