Daily Archives: April 19, 2022
Opinion | Low-grade prostate cancer (Gleason score 6): time to stop calling it cancer.
19 Apr, 2022 | 02:29h | UTCLow-Grade Prostate Cancer: Time to Stop Calling It Cancer – Journal of Clinical Oncology
Commentary: Doctors suggest new names for low-grade prostate cancer – Associated Press
AAOS Guideline: Prevention of surgical site infections after major extremity trauma.
19 Apr, 2022 | 02:35h | UTCEvidence Review: Prevention of Surgical Site Infection After Extremity Trauma (2022)
Video: Here’s what we know about COVID-19’s impact on the brain.
19 Apr, 2022 | 02:22h | UTCHere’s what we know about COVID-19’s impact on the brain – Science
Related:
SARS-CoV-2 is associated with changes in brain structure in UK Biobank – Nature
Nervous system consequences of COVID-19 – Science
The COVID generation: how is the pandemic affecting kids’ brains? – Nature
Assessment of Cognitive Function in Patients After COVID-19 Infection – JAMA Network Open
Omicron-specific Sinopharm, Sinovac COVID vaccine candidates cleared for clinical trial.
19 Apr, 2022 | 02:25h | UTCOmicron-specific Sinopharm, Sinovac COVID vaccine candidates cleared for clinical trial – Reuters
Commentary on Twitter
In China, #Omicron-specific vaccines are slated for clinical trials. The vaccine candidates were developed by a Sinopharm subsidiary and Sinovac Biotech. The vaccines are headed to clinical trials in Hong Kong https://t.co/6Y9LsGCKbn
— delthia ricks ? (@DelthiaRicks) April 17, 2022
M-A: Global prevalence of post COVID-19 condition or long COVID.
19 Apr, 2022 | 02:18h | UTCCommentary: Global data reveal half may have long COVID 4 months on – CIDRAP
Commentary on Twitter (thread – click for more)
?The so far largest meta-analysis of more than 1.5 million infected individuals puts the global prevalence of #LongCovid at 43%. Some additional key findings. ?https://t.co/XGu23MV3Ra
1/— Jonas R. Kunst (@KunstJonas) April 17, 2022
Opinion | Learning the art and science of diagnosis.
19 Apr, 2022 | 02:12h | UTCLearning the Art and Science of Diagnosis – JAMA (free for a limited period)
A systematic review of COVID-19 vaccine efficacy and effectiveness against SARS-CoV-2 infection and disease.
19 Apr, 2022 | 02:14h | UTC
Commentary on Twitter
???Systematic Review collected efficacy & effectiveness values by vaccine platform, disease outcome, number of doses, & SARS-CoV-2 variants
The spread of the Omicron beginning late 2021 is at least partially driven by reductions in vaccine effectiveness https://t.co/A7hDTQGY4K— Antibiotic Steward Bassam Ghanem?? (@ABsteward) April 18, 2022
AHA Scientific Statement: Management of hypertension in patients with ventricular assist devices.
19 Apr, 2022 | 02:09h | UTC
Acute hepatitis in ED setting: etiologies, evaluation, and management.
19 Apr, 2022 | 01:54h | UTCAcute Hepatitis in ED Setting: Etiologies, Evaluation, and Management – emDocs
RCT: Allopurinol is noninferior to febuxostat for controlling gout flares.
19 Apr, 2022 | 02:05h | UTCComparative Effectiveness of Allopurinol and Febuxostat in Gout Management – NEJM Evidence (link to abstract – $ for full-text)
Cohort Study: Association of treatment with antipsychotics, antidepressants, or both with movement disorders and seizures among children and adolescents with depression.
19 Apr, 2022 | 01:50h | UTC
Commentary on Twitter
In this cohort study, adjunctive antipsychotics with antidepressants were associated with movement disorders and seizures compared with antidepressant monotherapy in children and adolescents with depression. https://t.co/3SVKEThwkR
— JAMA Network Open (@JAMANetworkOpen) April 15, 2022
Pre-transplant EASIX (endothelial activation and stress index) may predict the hazard of sepsis after allogeneic stem cell transplantation.
19 Apr, 2022 | 02:04h | UTCPre-transplant EASIX and sepsis after allogeneic stem cell transplantation – Intensive Care Medicine
Commentary on Twitter
? Endothelial complications major causes of mortality post alloSCT. Pre Tx Endothelial Activation & Stress IndeX EASIX (basic lab data characterizing Tx-associated thrombotic microangiopathy) powerful marker of #sepsis, dysfunctional endothelial response.https://t.co/FRGUGT8L78 pic.twitter.com/VF2wTLCHaM
— Intensive Care Medicine (@yourICM) April 18, 2022
Analysis of an intervention for emergency medical services personnel to reduce epinephrine dosing errors in infants.
19 Apr, 2022 | 01:52h | UTC
Commentary on Twitter
In this QI study, an infant resuscitation simulation intervention using 1mL syringes to draw up epinephrine (vs dosing from prefilled 10mL syringes) was associated with increased appropriate epinephrine use & fewer dosage errors, in less time. https://t.co/M3ztB1LMDi
— JAMA Network Open (@JAMANetworkOpen) April 15, 2022
Development of a clinical polygenic risk score assay and reporting workflow.
19 Apr, 2022 | 01:39h | UTCDevelopment of a clinical polygenic risk score assay and reporting workflow – Nature Medicine
News Release: Newly Developed Genetic Risk Scores Could Help Patients, Physicians Make Health Decisions – Brigham and Women’s Hospital
Commentary on Twitter
The first report from the GenoVA Study provides preliminary insights on the development of a polygenic risk score assay in a clinical setting and discusses the challenges of generating, interpreting and reporting results @jasonvassy @MassGenBrigham https://t.co/zNNl35tMSs
— Nature Medicine (@NatureMedicine) April 18, 2022
Review: Paradoxical reactions to biologicals in chronic inflammatory systemic diseases.
19 Apr, 2022 | 01:48h | UTC
Phase 1–2 clinical trial: Rilzabrutinib, an oral BTK inhibitor, in immune thrombocytopenia.
19 Apr, 2022 | 01:35h | UTCRilzabrutinib, an Oral BTK Inhibitor, in Immune Thrombocytopenia – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Rilzabrutinib for blood disorder shows promise in phase 1–2 clinical trial – Massachusetts General Hospital
Commentary on Twitter
Rilzabrutinib had rapid and durable clinical activity in adults with immune thrombocytopenia, with low-level toxic effects. https://t.co/boWT4LpQkk pic.twitter.com/ZpNXHYL2Gv
— NEJM (@NEJM) April 18, 2022
Review: The safety of antirheumatic drugs.
19 Apr, 2022 | 01:42h | UTCThe Safety of Antirheumatic Drugs – Deutsches Ärzteblatt International
Palliative care for older people with dementia—we need a paradigm shift in our approach – “Advance care planning (ACP) is a central tenet of good dementia palliative care”.
19 Apr, 2022 | 01:30h | UTC
AI reduces miss rate of precancerous polyps in colorectal cancer screening.
19 Apr, 2022 | 01:32h | UTCNews Release: AI reduces miss rate of precancerous polyps in colorectal cancer screening – Mayo Clinic
Original Study: Impact of Artificial Intelligence on Miss Rate of Colorectal Neoplasia – Gastroenterology (link to abstract – $ for full-text)
Review | Frontline therapy for advanced hepatocellular carcinoma.
19 Apr, 2022 | 01:23h | UTC
Cluster RCT: BABEL (Better tArgeting, Better outcomes for frail ELderly patients) advance care planning: a comprehensive approach to advance care planning in nursing homes.
19 Apr, 2022 | 01:26h | UTC
Systematic Review: Perioperative complications and anesthesia practices in managing patients with quadriplegia undergoing surgery.
19 Apr, 2022 | 01:25h | UTC
10-year results of a phase 3 RCT: High-dose radiotherapy and risk-adapted androgen deprivation in localized prostate cancer.
19 Apr, 2022 | 01:22h | UTCHigh-dose radiotherapy and risk-adapted androgen deprivation in localised prostate cancer (DART 01/05): 10-year results of a phase 3 randomised, controlled trial – The Lancet Oncology (link to abstract – $ for full-text)
M-A of randomized trials: Intraoperative recurrent laryngeal nerve monitoring vs. visualization alone.
19 Apr, 2022 | 01:17h | UTC
ASCO Guideline Update: Use of immune checkpoint inhibitor Pembrolizumab in the treatment of high-risk, early-stage triple-negative breast cancer.
19 Apr, 2022 | 01:18h | UTC