Daily Archives: April 18, 2022
Public health doctors and scientists are investigating 74 cases of hepatitis in children living in the UK that were not caused by hepatitis A to E virus.
18 Apr, 2022 | 10:56h | UTCCommentaries:
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter (thread – click for more)
An update on hepatitis cases in children:
We are continuing to investigate 74 cases of hepatitis (liver inflammation) in children in the UK since January 2022. 1/2
— UK Health Security Agency (@UKHSA) April 12, 2022
RCT: In patients with acute Achilles’ tendon rupture, a nonoperative strategy resulted in similar outcomes compared with routine surgical treatment.
18 Apr, 2022 | 10:53h | UTCNonoperative or Surgical Treatment of Acute Achilles’ Tendon Rupture – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Heal Thyself: Most who tear Achilles tendon can skip surgery – Associated Press
Review: Covid-19: virology, variants, and vaccines.
18 Apr, 2022 | 10:50h | UTCCovid-19: virology, variants, and vaccines – BMJ Medicine
Commentary on Twitter
? New review on #COVID: virology, variants and vaccines by Megan Young, Harry Crook, Janet Scott and Paul Edison from @ImperialMed
➡️ Read it now! https://t.co/hYrCQYVvNr#BMJMedicine #MedTwitter pic.twitter.com/aGA0DsX38K— BMJMedicine (@BMJMedicine) April 14, 2022
Household transmission of SARS-CoV-2 from unvaccinated asymptomatic and symptomatic household members with confirmed SARS-CoV-2 infection: an antibody-surveillance study.
18 Apr, 2022 | 10:52h | UTCCommentary: COVID-19 household transmission is high, with children being a significant source of spread: study – CHEO
Commentary on Twitter (thread – click for more)
This new study on household transmission of #COVID19 from Canada is pretty interesting
-Children made up less than half index cases
-Adults odds of transmitting more than double vs children
-Mask use in household didn't reduce transmission— Alasdair Munro (@apsmunro) April 14, 2022
Analysis: Changing the assortment of available food and drink for leaner, greener diets.
18 Apr, 2022 | 10:39h | UTCChanging the assortment of available food and drink for leaner, greener diets – The BMJ
News Release: Changing products on offer in shops and restaurants can lead to leaner, greener diets – BMJ
EBM Analysis: Factors influencing estimated effectiveness of COVID-19 vaccines in non-randomized studies.
18 Apr, 2022 | 10:48h | UTC
Commentary on Twitter
Factors influencing estimated effectiveness of COVID-19 vaccines in non-randomised studies – by John P A Ioannidis#OpenAccess
▶️ https://t.co/ddc2xF4hdg pic.twitter.com/okUAdQwb85— BMJ Evidence-Based Medicine (@BMJ_EBM) April 15, 2022
RCT: A 12-months oral itraconazole regimen is superior to 6-months of treatment to prevent relapses of chronic pulmonary aspergillosis.
18 Apr, 2022 | 10:36h | UTCEfficacy of 12-months oral itraconazole versus 6-months oral itraconazole to prevent relapses of chronic pulmonary aspergillosis: an open-label, randomised controlled trial in India – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Cohort Study: Changes in the incidence of retinal vascular occlusions after COVID-19 diagnosis.
18 Apr, 2022 | 10:34h | UTCCommentaries:
COVID-19 Diagnosis and Incidence of Retinal Thromboembolism – JAMA Ophthalmology
Threatening Eye Condition Rare After COVID Infection – HealthDay
M-A: Myopericarditis following COVID-19 vaccination and non-COVID-19 vaccination.
18 Apr, 2022 | 10:32h | UTCCommentaries:
Myopericarditis following COVID-19 vaccination is rare, finds international study – The Lancet
Study explores myopericarditis incidence and COVID-19 vaccination – News Medical
Commentary on Twitter
NEW—Myopericarditis following #COVID19 vaccination is rare, finds international study published in @LancetRespirMed: https://t.co/d3ZRvTWrGB pic.twitter.com/6sHiRyEbTk
— The Lancet (@TheLancet) April 11, 2022
AHA Scientific Statement: Nonalcoholic fatty liver disease and cardiovascular risk.
18 Apr, 2022 | 10:37h | UTCNews Releases:
Fatty liver disease not caused by alcohol is common – and often missed – American Heart Association
Diarrhea during critical illness: a multicenter cohort study.
18 Apr, 2022 | 10:20h | UTCDiarrhea during critical illness: a multicenter cohort study – Intensive Care Medicine
Commentary on Twitter
Diarrhea in #ICU
➡️common but variable incidence (definition applied)
➡️rarely caused by Clostridioides difficile
➡️modifiable predictors include EN/duration of ABs exposure
➡️associated with longer time to discharge but not increased mortality#FOAMcc
? https://t.co/Wx0T7RWukV pic.twitter.com/CvhWgTEwJb— Intensive Care Medicine (@yourICM) April 14, 2022
Commentary: Loneliness and health.
18 Apr, 2022 | 10:16h | UTCLoneliness and health – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Related:
The prevalence of loneliness across 113 countries: systematic review and meta-analysis – The BMJ
Social Isolation and Loneliness – World Health Organization
Psychological Distress and Loneliness Reported by US Adults in 2018 and April 2020 – JAMA
Commentary on Twitter
In this Comment, Louise Hawkley discusses associations of #Loneliness with increased mortality and disease risk, and that a multi-level approach including individuals, community organizations and society is needed to reduce loneliness.@NORCNewshttps://t.co/CzP5fR6G0n pic.twitter.com/X3use2Aybe
— Nature Reviews Disease Primers (@DiseasePrimers) April 14, 2022
Guidelines for therapeutic drug monitoring of vancomycin in the framework of model-informed precision dosing.
18 Apr, 2022 | 10:26h | UTCRelated Guideline:
Commentary on Twitter
?Rings Cowbell?
New Vancomycin guidelines drop from Japan.This is the most written about the need for #PrecisionDosing that I have seen.
Give patients the dose they need because #OneSizeFitsNone@SIDPharm @ABsteward @IDstewardship https://t.co/wlwgkqZmXu
— Marc H. Scheetz (@IDPharmacometrx) April 13, 2022
RCT: Mitapivat vs. placebo for Pyruvate Kinase Deficiency.
18 Apr, 2022 | 10:13h | UTCMitapivat versus Placebo for Pyruvate Kinase Deficiency – New England Journal of Medicine
An observational study in patients with chronic kidney disease suggests the optimum range of water intake is around 1–2 L/day.
18 Apr, 2022 | 10:12h | UTC
A preliminary study showed prolonged viral suppression is feasible with anti-HIV-1 antibody therapy.
18 Apr, 2022 | 10:06h | UTCProlonged viral suppression with anti-HIV-1 antibody therapy – Nature
Commentary on Twitter
Still in disbelief but our paper is now out in @nature!
We show that immunotherapy with two broadly neutralizing anti-HIV-1 antibodies maintains virologic suppression for several months in people living with HIV in the absence of anti-retroviral therapy.https://t.co/eVem5yDE0C
— Christian Gaebler (@c_gaebler) April 14, 2022
A randomized controlled trial explored the safety and tolerability of Sulthiame in sleep apnea.
18 Apr, 2022 | 10:08h | UTCNews Release: Drug reduced frequency of breathing pauses in sleep apnea – University of Gothenburg
Commentary on Twitter
In a four-week trial of patients with OSA not tolerating PAP therapy, researchers found that the carbonic anhydrase inhibitor sulthiame reduced OSA by more than 20 events per hour, one of the strongest reductions reported in a drug trial in OSA. https://t.co/EizlbFbvFm pic.twitter.com/DxylRQR4Pa
— American Academy of Sleep Medicine (@AASMorg) February 28, 2022
The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates.
18 Apr, 2022 | 10:03h | UTCNews Release: Global estimates of headaches suggest disorder impacts over 50 percent of the population – BMC
Review: Management challenges and therapeutic advances in congenital adrenal hyperplasia.
18 Apr, 2022 | 10:10h | UTCManagement challenges and therapeutic advances in congenital adrenal hyperplasia – Nature Reviews Endocrinology (if the link is paywalled, try this one)
Commentary on Twitter
New content online: Management challenges and therapeutic advances in congenital adrenal hyperplasia https://t.co/RCH4mRmvYe pic.twitter.com/76Jm00ISV1
— Nature Reviews Endocrinology (@NatureRevEndo) April 11, 2022
RCT: Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people.
18 Apr, 2022 | 10:01h | UTCEditorial: Pointing a FINGER at the contribution of lifestyle to cardiovascular events and dementia
Commentary on Twitter
Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial https://t.co/fkUJQQ9MyZ @escardio #EHJ #ESCYoung #cardiotwitter @ehj_ed @rladeiraslopes pic.twitter.com/sU0LVF8agJ
— European Society of Cardiology Journals (@ESC_Journals) February 1, 2022
Prospective validation of a rapid host gene expression test to discriminate bacterial from viral respiratory infection.
18 Apr, 2022 | 09:58h | UTC
Commentary on Twitter
In this diagnostic study, a new host gene expression test identified patients unlikely to have bacterial infection in only 45 minutes, a potential new tool for antibiotic stewardship. https://t.co/3JiYl2N4b0
— JAMA Network Open (@JAMANetworkOpen) April 14, 2022
RCT: Among patients waiting for total knee arthroplasty with a BMI above 35, bariatric surgery before the procedure was associated with reduced risk of complications.
18 Apr, 2022 | 09:52h | UTCCommentary: Bariatric Surgery Before TKA Cuts Complications in Obese Patients – HealthDay
Commentary on Twitter
In this RCT, bariatric surgery before knee replacement (TKA) reduced the risk of complications in TKA in adults <65y with class II obesity scheduled to undergo TKA; 30% had sufficient symptom improvement to decline TKA altogether. https://t.co/qyhl0eIV2o
— JAMA Network Open (@JAMANetworkOpen) April 14, 2022
Incidence of electric scooter–associated injuries in Finland from 2019 to 2021.
18 Apr, 2022 | 09:54h | UTCIncidence of Electric Scooter–Associated Injuries in Finland From 2019 to 2021 – JAMA Network Open
Commentary on Twitter
This cross-sectional study found that actual incidence of any injury and major trauma was 18/100k and 5.9/100k trips taken with rental e-scooters in Finland. https://t.co/ZKz1j219vQ
— JAMA Network Open (@JAMANetworkOpen) April 14, 2022
RCT: Long-term efficacy and safety of up to 108 weeks of Ixekizumab in pediatric patients with moderate to severe plaque psoriasis.
18 Apr, 2022 | 09:49h | UTC
Commentary on Twitter
In this RCT, by 108 weeks of use of ixekizumab for pediatric psoriasis, PASI 75/90/100 were achieved in 92%/79%/55%, respectively, of children, with clearance of nails in 68%, scalp in 76%, genital lesions in 88%, and palm/sole involvement in 90%. https://t.co/vk73Z3MKi4
— JAMA Dermatology (@JAMADerm) April 13, 2022
Cross-sectional study: evaluating prediction models of sleep apnea from smartphone-recorded sleep breathing sounds.
18 Apr, 2022 | 09:44h | UTCEvaluating Prediction Models of Sleep Apnea From Smartphone-Recorded Sleep Breathing Sounds – JAMA Otolaryngology-Head & Neck Surgery (link to abstract – for full-text)
Commentary on Twitter
Study found, smartphone-recorded #sleep breathing sounds may be used to create prediction models for obstructive sleep apnea, but additional verification of real-life recordings using various smartphone devices should be conducted. #OSA https://t.co/3ESRYefsyj
— JAMA Otolaryngology – Head & Neck Surgery (@JAMAOto) April 14, 2022