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Daily Archives: April 5, 2022

Billions of people still breathe unhealthy air: new WHO data.

5 Apr, 2022 | 09:59h | UTC

News Release: Billions of people still breathe unhealthy air: new WHO data – World Health Organization

Report: WHO Air quality Database 2022

Commentaries:

South-East Asia, Africa and Middle East are World’s Air Pollution Hot Spots in WHO’s Largest-Ever Data Release – Health Policy Watch

WHO says 99% of world’s population breathes poor-quality air – Associated Press

Related: New WHO Global Air Quality Guidelines aim to save millions of lives from air pollution.

 

Commentary on Twitter (thread – click for more)

 

Systematic Review: Videolaryngoscopy vs. direct laryngoscopy for adults undergoing tracheal intubation.

5 Apr, 2022 | 09:52h | UTC

Videolaryngoscopy versus direct laryngoscopy for adults undergoing tracheal intubation – Cochrane Library

 

Commentary from the author on Twitter (thread – click for more)

 

#ACC22 – RCT: In patients undergoing non-cardiac surgery, a strategy of aggressive intraoperative warming (target core temperature of 37°C) did not reduce major complications compared to routine thermal management (target of 35·5°C).

5 Apr, 2022 | 09:57h | UTC

Aggressive intraoperative warming versus routine thermal management during non-cardiac surgery (PROTECT): a multicentre, parallel group, superiority trial – The Lancet (free registration required)

Commentary: PROTECT: Aggressive Warming During Surgery Does Not Reduce Major Complications – American College of Cardiology

 

Consensus Statement: Definition, diagnosis, and management of COVID-19-associated pulmonary mucormycosis.

5 Apr, 2022 | 09:54h | UTC

Definition, diagnosis, and management of COVID-19-associated pulmonary mucormycosis: Delphi consensus statement from the Fungal Infection Study Forum and Academy of Pulmonary Sciences, India – The Lancet Infectious Diseases

 

Perspective: The evidence on 4th doses of covid vaccines & the thorny question of age thresholds.

5 Apr, 2022 | 09:46h | UTC

The Evidence On 4th Doses of Covid Vaccines & the Thorny Question of Age Thresholds – Absolutely Maybe Blog, by Hilda Bastian

Related:

U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.

[Preprint] Retrospective cohort study: second booster vaccine and Covid-19 mortality in adults 60 to 100 years old.

Among health care workers, a fourth dose vaccine effectiveness against any SARS-CoV-2 Omicron variant infection was 30% for the Pfizer–BioNTech and 11% for the Moderna.

[Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.

Covid-19: Fourth vaccine doses—who needs them and why?

[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.

 

Commentary on Twitter

 

Seminar: Acute coronary syndromes.

5 Apr, 2022 | 09:48h | UTC

Acute coronary syndromes – The Lancet (free for a limited period)

 

Commentary on Twitter

 

Opinion | Medicinal cannabis for chronic pain: the Bermuda triangle of low-quality studies, countless meta-analyses and conflicting recommendations.

5 Apr, 2022 | 08:52h | UTC

Medicinal Cannabis for Chronic Pain: The Bermuda Triangle of Low Quality Studies, Countless Meta-analyses and Conflicting Recommendations – European Journal of Pain

Related:

RCT: Effect of medical marijuana card ownership on pain, insomnia, and affective disorder symptoms in adults.

Cohort Study: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife.

AHA Scientific Statement | How does cannabis use affect brain health? Caution advised, more research needed.

M-A: Birth outcomes of neonates exposed to marijuana in utero.

Cannabis-related allergies: an international overview and consensus recommendations.

Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions.

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain.

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use.

Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.

Guideline: Medical cannabis or cannabinoids for chronic pain.

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

Review: Considerations for cannabinoids in perioperative care by anesthesiologists.

Review: Cannabis-based Medicines and the Perioperative Physician

Study: Cannabis Use Disorder May Increase the Risk of Cardiovascular Events in Major Elective Surgeries

Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know

Perioperative Care of Cannabis Users: A Comprehensive Review of Pharmacological and Anesthetic Considerations

 

Cohort study: Increased middle age serum sodium levels (may correlate with low water ingestion) are linked to increased risk of left ventricular hypertrophy and heart failure after 25 years of follow up.

5 Apr, 2022 | 09:44h | UTC

Middle age serum sodium levels in the upper part of normal range and risk of heart failure – European Heart journal (link to abstract – $ for full-text)

News Release: Good hydration may reduce long-term risks for heart failure – Serum sodium levels may help identify adults with a greater chance of experiencing heart disease. – National Institutes of Health

 

Cohort Study: Change in heart disease and stroke mortality before and during the Covid-19 pandemic.

5 Apr, 2022 | 08:47h | UTC

Age-Adjusted Mortality Rates and Age and Risk–Associated Contributions to Change in Heart Disease and Stroke Mortality, 2011-2019 and 2019-2020 – JAMA Network Open

Commentaries:

Several-Fold Increase in Stroke and Heart Disease Deaths During COVID-19 Pandemic – NeurologyToday

2019 to 2020 Saw Risk-Linked Deaths From Heart Disease, Stroke Up – HealthDay

 

Commentary from the author on Twitter (thread – click for more). Article and images under CC-BY License

 

#ACC22 – RCT: Edoxaban vs. dual antiplatelet therapy for preventing leaflet thrombosis and cerebral thromboembolism after TAVR.

5 Apr, 2022 | 08:45h | UTC

Edoxaban versus Dual Antiplatelet Therapy for Leaflet Thrombosis and Cerebral Thromboembolism after TAVR: The ADAPT-TAVR Randomized Clinical Trial – Circulation

Commentary:

No reduction in stroke, mini strokes, blood clotting or changes in cognitive function with edoxaban after TAVR – American College of Cardiology

ADAPT-TAVR: Edoxaban vs. DAPT in Reducing SLT and Cerebral Thromboembolism After TAVR – American College of Cardiology

Related:

M-A: Single antiplatelet therapy should be used after transcatheter aortic valve implantation in patients without indication for anticoagulation.

M-A: Aspirin alone better than dual antiplatelet therapy after transcatheter aortic valve implantation

#ESCCongress – [Abstract Only] Randomized trial: aspirin with or without clopidogrel after transcatheter aortic-valve implantation

#ACC21 – [Not published yet] RCT: Among patients undergoing TAVR, full-dose apixaban is not superior to standard of care (vitamin K antagonist if indication for oral anticoagulation; antiplatelet therapy if no indication).

#AHA19 – [Abstract Only] Randomized Trial: An Antiplatelet-based Strategy is Associated with Better Outcomes vs. Anticoagulation After Transcatheter Aortic-Valve Replacement

 

Commentary on Twitter

 

EHRA consensus on prevention and management of interference due to medical procedures in patients with cardiac implantable electronic devices.

5 Apr, 2022 | 08:39h | UTC

EHRA consensus on prevention and management of interference due to medical procedures in patients with cardiac implantable electronic devices – EP Europace

News Release: Advice to prevent consequences of interference in cardiac device patients published today – European Society of Cardiology

 

RCT: Efficacy, safety, and immunogenicity of the DNA SARS-CoV-2 vaccine (ZyCoV-D).

5 Apr, 2022 | 08:50h | UTC

Efficacy, safety, and immunogenicity of the DNA SARS-CoV-2 vaccine (ZyCoV-D): the interim efficacy results of a phase 3, randomised, double-blind, placebo-controlled study in India – The Lancet

Invited Commentary: DNA vaccines join the fight against COVID-19 – The Lancet

 

Commentary on Twitter

 

EHRA practical guide: How to use digital devices to detect and manage arrhythmias.

5 Apr, 2022 | 08:41h | UTC

How to use digital devices to detect and manage arrhythmias: an EHRA practical guide – EP Europace

News Release: Advice on how to use digital devices to detect and manage arrhythmias published today – European Society of Cardiology

 

Review: Antiplatelet therapy after percutaneous coronary intervention.

5 Apr, 2022 | 08:38h | UTC

Antiplatelet therapy after percutaneous coronary intervention – EuroIntervention

 

Commentary on Twitter

 

M-A: Efficacy of interventions to reduce long term opioid treatment for chronic non-cancer pain.

5 Apr, 2022 | 08:29h | UTC

Efficacy of interventions to reduce long term opioid treatment for chronic non-cancer pain: systematic review and meta-analysis – The BMJ

 

Expert Consensus Statement on the state of genetic testing for cardiac diseases.

5 Apr, 2022 | 08:31h | UTC

European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) Expert Consensus Statement on the state of genetic testing for cardiac diseases

News Release: Recommendations on genetic testing for inherited cardiac diseases published today – European Society of Cardiology

 

Commentary on Twitter

 

Cohort Study: Childhood cardiovascular risk factors and adult cardiovascular events.

5 Apr, 2022 | 08:23h | UTC

Childhood Cardiovascular Risk Factors and Adult Cardiovascular Events – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT: Efficacy and safety of Daprodustat (oral drug) for treating anemia of chronic kidney disease in incident dialysis patients.

5 Apr, 2022 | 08:34h | UTC

Efficacy and Safety of Daprodustat for Treatment of Anemia of Chronic Kidney Disease in Incident Dialysis Patients: A Randomized Clinical Trial – JAMA Internal Medicine

Related:

RCT: In patients with chronic kidney diseases and anemia undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa to increase hemoglobin levels and regarding cardiovascular outcomes.

RCT: In patients with chronic kidney diseases and anemia not undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa in increasing hemoglobin levels and regarding cardiovascular outcomes.

 

Commentary on Twitter

 

Review: The intensivist’s perspective of shock, volume management, and hemodynamic monitoring.

5 Apr, 2022 | 08:20h | UTC

The Intensivist’s Perspective of Shock, Volume Management, and Hemodynamic Monitoring – Clinical Journal of the American Society of Nephrology

 

Commentary on Twitter

 

Podcast: Acute pancreatitis pearls.

5 Apr, 2022 | 08:26h | UTC

#327 Acute Pancreatitis – The Curbsiders

 

Review: Patient-centered approaches for the management of unpleasant symptoms in kidney disease.

5 Apr, 2022 | 08:16h | UTC

Patient-centred approaches for the management of unpleasant symptoms in kidney disease – Nature Reviews Nephrology

 

Commentary on Twitter

 

Pericardial effusion and cardiac tamponade: pearls and pitfalls.

5 Apr, 2022 | 08:13h | UTC

Pericardial Effusion and Cardiac Tamponade: Pearls and Pitfalls – emDocs

 

Systematic Review: Prostatic arterial embolization for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia.

5 Apr, 2022 | 08:10h | UTC

Prostatic arterial embolization for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia – Cochrane Library

Summary: Prostatic arterial embolization for treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia – Cochrane Library

 

Systematic Review: Endovascular vs. conventional open surgical repair for thoracoabdominal aortic aneurysms.

5 Apr, 2022 | 08:11h | UTC

Endovascular versus conventional open surgical repair for thoracoabdominal aortic aneurysms – Cochrane Library

Summary: Are patient outcomes superior after endovascular or open surgical repair of thoracoabdominal aortic aneurysms? – Cochrane Library

 

Commentary on Twitter

 

Systematic Review: Timing of antibiotic administration, wound debridement, and the stages of reconstructive surgery for open long bone fractures of the upper and lower limbs.

5 Apr, 2022 | 08:08h | UTC

Timing of antibiotic administration, wound debridement, and the stages of reconstructive surgery for open long bone fractures of the upper and lower limbs – Cochrane Library

Summary: The timing of treatment for broken bones in the legs and arms that also have open wounds – Cochrane Library

 

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