Daily Archives: March 11, 2022
RCT: Methenamine Hippurate (a non-antibiotic preventive treatment) is noninferior to prophylactic antibiotics for treating recurrent urinary tract infections in women.
11 Mar, 2022 | 10:21h | UTCNews Release: Antiseptic drug as good as antibiotics for preventing recurrent urinary tract infections – BMJ Newsroom
Editorial: Methenamine hippurate for recurrent urinary tract infections – The BMJ
Commentaries:
Trial supports antibiotic alternative for recurrent urinary infections – CIDRAP
Nonantibiotic Prophylaxis Noninferior for Recurrent UTI – HealthDay
Commentary on Twitter
The antiseptic drug methenamine hippurate is as good as antibiotics for preventing recurrent urinary tract infections in women, finds this trial
Includes a visual abstract displaying the findings #BMJInfographic https://t.co/LJNx2OEKhO @chrisharding123 pic.twitter.com/CjxWtjao6r
— The BMJ (@bmj_latest) March 10, 2022
Systematic Review: Inhaled corticosteroids for the treatment of COVID‐19.
11 Mar, 2022 | 10:18h | UTCInhaled corticosteroids for the treatment of COVID‐19 – Cochrane Library
Related:
[Preprint] M-A: Inhaled corticosteroids in COVID-19 outpatients.
Position Paper: Recommendations for the use of topical inhalant budesonide in COVID-19.
RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19
Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19
Commentary on Twitter (thread – click for more)
Are inhaled #corticosteroids an effective treatment for people with mild #COVID19?
New #systematicreview from @CochraneAirways looks at using this well established treatment for asthma & COPD as a #COVIDtreatment https://t.co/dxUtudHLiW 1/4 pic.twitter.com/4nUs56Xfsg— The Cochrane Library (@CochraneLibrary) March 9, 2022
WHO Guidance: Use of SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing.
11 Mar, 2022 | 10:20h | UTC
Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21.
11 Mar, 2022 | 10:16h | UTCCommentaries:
COVID’s true death toll: far higher than official records – Nature
Covid deaths probably three times higher than records say – BBC
Related:
Editorial: “Excess deaths” is the best metric for tracking the pandemic.
The pandemic’s true death toll: millions more than official counts.
Global Covid-19 deaths surpass five million.
Under-reporting of deaths limits our understanding of true burden of covid-19.
Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.
Just how do deaths due to COVID-19 stack up?
Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.
COVID-19 has caused 6.9 million deaths globally, more than double what official reports show
Commentary on Twitter
? @TheLancet
This week it was widely announced we surpassed 6 million global Covid deaths.
The real number is likely more than 18 million, as determined by excess mortality at the end of 2021.https://t.co/VGHm5MID9i pic.twitter.com/DyYk6fLmWX— Eric Topol (@EricTopol) March 10, 2022
COVID pandemic 2nd anniversary: 3 things we got wrong, and 3 things to watch out for.
11 Mar, 2022 | 10:07h | UTC
Misinformation: susceptibility, spread, and interventions to immunize the public.
11 Mar, 2022 | 10:03h | UTCMisinformation: susceptibility, spread, and interventions to immunize the public – Nature Medicine
See also: An epidemic of uncertainty: rumors, conspiracy theories and vaccine hesitancy – Nature Medicine
Another study suggests that a third vaccine dose is necessary to protect populations against the omicron variant.
11 Mar, 2022 | 10:14h | UTCNews Release: Third vaccine dose critical for protecting populations against omicron variant – BMJ Newsroom
Commentary on Twitter
mRNA vaccines are highly effective in preventing covid-19 associated hospital admissions related to the alpha, delta, and omicron variants. But three doses are needed to achieve a similar level of protection against omicron, finds a large US study: https://t.co/YMm176gmby
— The BMJ (@bmj_latest) March 10, 2022
Retrospective Cohort Study: Frequency and outcomes of MRI-detected axillary adenopathy following COVID-19 vaccination.
11 Mar, 2022 | 10:05h | UTCRelated:
2 Case Series and Guidance | Lymphadenopathy in COVID-19 Vaccine Recipients
RCT: Effect of offering care management or online dialectical behavior therapy skills training vs. usual care on self-harm among adult outpatients with suicidal ideation (important negative study).
11 Mar, 2022 | 10:01h | UTCEffect of Offering Care Management or Online Dialectical Behavior Therapy Skills Training vs Usual Care on Self-harm Among Adult Outpatients With Suicidal Ideation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: Low-Intensity Care Options Flop for Self-Harm Prevention— In randomized trial, two therapeutic interventions failed to help people with suicidal thoughts – MedPage Today (free registration required)
See also: Visual Abstract
Commentary on Twitter
1/ Let's see if I understand this. You take people who are in so much pain, they want to die. They're likely feeling that no one really cares about them. And you provide "interventions… delivered primarily through electronic health record online messaging." What could go wrong? https://t.co/865QyJp7Dg
— Jonathan Shedler (@JonathanShedler) February 16, 2022
Optimizing hospital electronic prescribing systems: a systematic scoping review.
11 Mar, 2022 | 10:02h | UTC
SHEA neonatal intensive care unit (NICU) white paper series: Practical approaches for preventing central line-associated bloodstream infections.
11 Mar, 2022 | 09:53h | UTC
Report: Measuring sex, gender identity, and sexual orientation.
11 Mar, 2022 | 09:55h | UTCCommentary: NIH-funded study offers recommendations for measuring gender, sexual orientation – Healthcare IT News
WHO issues new guidelines on abortion to help countries deliver lifesaving care.
11 Mar, 2022 | 09:56h | UTCNews Release: WHO issues new guidelines on abortion to help countries deliver lifesaving care – World Health Organization
See Guidance: Abortion care guideline – World Health Organization
Commentary: New WHO Abortion Guidelines Include Telemedicine for First Time – Health Policy Watch
Commentary on Twitter (thread – click for more)
NEW: WHO releases consolidated guidelines on quality abortion care, aiming to help protect the health of women and girls, and prevent the 25 million unsafe abortions that occur each year https://t.co/GqVOgUEZPl pic.twitter.com/63RTUGUalr
— World Health Organization (WHO) (@WHO) March 9, 2022
RCT: Safety and efficacy of three enteral feeding strategies in patients with severe stroke.
11 Mar, 2022 | 09:51h | UTCSafety and efficacy of three enteral feeding strategies in patients with severe stroke in China (OPENS): a multicentre, prospective, randomised, open-label, blinded-endpoint trial – The Lancet Neurology (link to abstract – $ for full-text)
Methods primer: Data linkage in medical research.
11 Mar, 2022 | 09:44h | UTCData linkage in medical research – BMJ Medicine
Commentary on Twitter
“Methods to quantify, interpret and account for errors are needed, alongside guidelines for transparent reporting.” @Klharron.
Read more ➡️ https://t.co/ctrowLbqD9 #MedTwitter #BMJMedicine @ich_ppp @Richard_D_Riley @rafaoxford pic.twitter.com/QXl0HcE8nh— BMJMedicine (@BMJMedicine) March 7, 2022
Efficacy and safety of non-operative management of uncomplicated acute appendicitis compared to appendectomy: an umbrella review of systematic reviews and meta-analyses.
11 Mar, 2022 | 09:49h | UTCRelated:
Review: Diagnosis of uncomplicated and complicated appendicitis in adults.
A Randomized trial comparing antibiotics with appendectomy for appendicitis
RCT: Overall survival with Ribociclib plus Letrozole in advanced breast cancer.
11 Mar, 2022 | 09:47h | UTCOverall Survival with Ribociclib plus Letrozole in Advanced Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Adding Ribociclib to Letrozole Prolongs Survival in Advanced Breast Cancer – HealthDay
Review: Hypertensive eye disease.
11 Mar, 2022 | 09:42h | UTCHypertensive eye disease – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Infographic: Hypertensive eye disease (if the link is paywalled, try this one)
Commentary on Twitter
Get Primed on Hypertensive Eye Disease with our NEW PrimeView! FREE to download this week!#Hypertensionhttps://t.co/yL0WSHIJiH pic.twitter.com/HKPdssJGNR
— Nature Reviews Disease Primers (@DiseasePrimers) March 10, 2022
Association between statin use and daptomycin-related musculoskeletal adverse events: A mixed approach combining a meta-analysis and a disproportionality analysis.
11 Mar, 2022 | 09:39h | UTC
Systematic Review: Antiplatelet agents for chronic kidney disease.
11 Mar, 2022 | 09:35h | UTCAntiplatelet agents for chronic kidney disease – Cochrane Library
Review: Acute cholecystitis.
11 Mar, 2022 | 09:40h | UTCAcute Cholecystitis: A Review – JAMA (free for a limited period)
Author Interview: Acute Cholecystitis
RCT: In pediatric ICUs, a bundled intervention that emphasized a physiologically focused cardiopulmonary resuscitation training did not improve outcomes in cardiac arrest.
11 Mar, 2022 | 09:37h | UTCEffect of Physiologic Point-of-Care Cardiopulmonary Resuscitation Training on Survival With Favorable Neurologic Outcome in Cardiac Arrest in Pediatric ICUs: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: CPR Intervention Failed to Improve Survival in Kids With Cardiac Arrest — Physiologically focused CPR training did not lead to difference in survival to discharge – MedPage Today (free registration required)
Commentary on Twitter
Among patients in pediatric ICUs, a bundled intervention that emphasized physiologically focused CPR training and structured clinical event debriefing did not significantly improve patient survival to hospital discharge with favorable neurologic outcome. https://t.co/MbmmSM0Xrt
— JAMA (@JAMA_current) March 8, 2022
Nationwide analysis of persistent type II endoleak and late outcomes of endovascular abdominal aortic aneurysm repair in Japan: a propensity-matched analysis.
11 Mar, 2022 | 09:32h | UTCCommentary: Type II Endoleak and EVAR Outcomes for Abdominal Aortic Aneurysm – American College of Cardiology
Expert Analysis: Clinical practice algorithm for the follow-up of unrepaired and repaired secundum atrial septal defects.
11 Mar, 2022 | 09:31h | UTC
Comparing bowel lengthening procedures: which, when, and why?
11 Mar, 2022 | 09:33h | UTC