Daily Archives: March 10, 2022
RCT: In patients with refractory out-of-hospital cardiac arrest, a strategy of intra-arrest transport, extracorporeal cardiopulmonary resuscitation, and immediate invasive assessment did not significantly improve survival with a favorable neurological outcome (OR 1.63; 95% CI 0.93 to 2.85; P = .09).
10 Mar, 2022 | 10:57h | UTCEffect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: Early Invasive Therapy for Out-of-Hospital Cardiac Arrest – American College of Cardiology
Commentary on Twitter
In this randomized clinical trial, early intra-arrest transport, extracorporeal CPR, and invasive assessment and treatment did not significantly improve survival with neurologically favorable outcome at 180 days compared with standard resuscitation. https://t.co/qSqWSFFpOF pic.twitter.com/SLu0bGHhq8
— JAMA (@JAMA_current) February 22, 2022
RCT: In patients with low-risk thyroid cancer, thyroidectomy without ablation radioiodine was noninferior to thyroidectomy with ablation radioiodine at 3 years.
10 Mar, 2022 | 10:59h | UTCThyroidectomy without Radioiodine in Patients with Low-Risk Thyroid Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: New research casts doubt on a cornerstone of thyroid cancer treatment – STAT
Commentary on Twitter
In RCT involving patients with low-risk differentiated thyroid cancer undergoing thyroidectomy, a follow-up strategy that did not involve the use of radioiodine was noninferior to the use of radioiodine in the response to treatment at 3 years. https://t.co/RaJL3tdE4T pic.twitter.com/8nIPw50nkg
— NEJM (@NEJM) March 9, 2022
RCT: In children with nonsevere, drug-susceptible tuberculosis, treatment for 4 months is noninferior to treatment for 6 months.
10 Mar, 2022 | 11:03h | UTCNews Release: Treatment length reduced for children with tuberculosis – University College London
Commentary on Twitter
Completing 6 months of treatment for tuberculosis in children is a challenge. In this open-label trial involving 1204 children in sub-Saharan Africa and India, 4 months of antituberculosis therapy was noninferior to 6 months of therapy. https://t.co/zkD4URWMru pic.twitter.com/LFR6ZzTKgs
— NEJM (@NEJM) March 9, 2022
Meta-analysis of randomized trials: benefits and harms of direct oral anticoagulation and low molecular weight heparin for thromboprophylaxis in patients undergoing non-cardiac surgery.
10 Mar, 2022 | 10:48h | UTC
Commentary on Twitter
Led by Maura Marcucci, network meta-analysis of of 68 surgery #RCT's (45,445 patients; mainly #ortho) found that #DOAC's & #LMWH reduce #VTE but probably increase major bleeding to a similar extent. DOACs probably prevent symptomatic VTE more than #LMWH. https://t.co/7vrgVpfD3s pic.twitter.com/H5Fuq7p1hi
— Kari Tikkinen (@KariTikkinen) March 9, 2022
M-A: Comparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia.
10 Mar, 2022 | 10:54h | UTCComparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia: a systematic review and network meta-analysis – The Lancet (link to abstract – $ for full-text)
Perspective: Once viewed as a promising COVID-19 treatment, convalescent plasma falls out of favor.
10 Mar, 2022 | 10:47h | UTCOnce Viewed as a Promising COVID-19 Treatment, Convalescent Plasma Falls Out of Favor – JAMA
Perspective: What do we know about Covid’s impact on the brain?
10 Mar, 2022 | 10:46h | UTCWhat do we know about Covid’s impact on the brain? – The Guardian
Related: SARS-CoV-2 is associated with changes in brain structure in UK Biobank.
New WHO/ILO guide urges greater safeguards to protect health workers.
10 Mar, 2022 | 10:42h | UTCNew WHO/ILO guide urges greater safeguards to protect health workers – World Health Organization
Executive Summary: Caring for those who care: Guide for the development and implementation of occupational health and safety programmes for health workers – World Health Organization
Updated guideline summary introduces new recommendations for use of medications around total hip and knee replacement.
10 Mar, 2022 | 10:45h | UTCGuideline Summary (full guideline not available yet): 2022 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients with Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty – American College of Rheumatology
Recommendations for diagnosis and prevention of Cytomegalovirus-associated necrotizing enterocolitis in breast-fed preterm infants.
10 Mar, 2022 | 10:37h | UTC
Guideline: Implementing advance care plans in the peri-operative period, including plans for cardiopulmonary resuscitation.
10 Mar, 2022 | 10:40h | UTC
AAP Technical Report | Telehealth: Opportunities to improve access, quality, and cost in pediatric care.
10 Mar, 2022 | 10:41h | UTCTelehealth: Opportunities to Improve Access, Quality, and Cost in Pediatric Care – Pediatrics
News Release: New AAP report reviews telehealth’s potential to transform pediatric care – AAP News
GEC ESTRO ACROP consensus recommendations for contact brachytherapy for rectal cancer.
10 Mar, 2022 | 10:35h | UTC
Systematic Review: Pharmacotherapy for post-traumatic stress disorder.
10 Mar, 2022 | 10:30h | UTCPharmacotherapy for post traumatic stress disorder (PTSD) – Cochrane Library
Evidence-based clinical practice guidelines for gastroesophageal reflux disease.
10 Mar, 2022 | 10:34h | UTCRelated:
ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease.
SAGES guidelines for the surgical treatment of gastroesophageal reflux.
Guideline on Screening for Esophageal Adenocarcinoma in Patients with Chronic GERD
NICE Guideline: Gastro-esophageal Reflux Disease and Dyspepsia in Adults
NICE Guideline: Gastroesophageal Reflux Disease in Children and Young People
Review article: current and emerging therapies for the management of cirrhosis and its complications.
10 Mar, 2022 | 10:33h | UTC
Breast cancer risk evaluation for the primary care physician.
10 Mar, 2022 | 10:30h | UTCBreast cancer risk evaluation for the primary care physician – Cleveland Clinic Journal of Medicine
M-A: Outcomes of people living with HIV after hospital discharge.
10 Mar, 2022 | 10:26h | UTC
Commentary on Twitter (thread – click for more)
New: Outcomes of people living with HIV after hospital discharge: a systematic review and meta-analysis by Nathan Ford and colleagues https://t.co/5xurY4Sxm0 #openaccess
— The Lancet HIV (@TheLancetHIV) March 3, 2022
RCT: Comparing methotrexate monotherapy with methotrexate plus leflunomide combination therapy in psoriatic arthritis.
10 Mar, 2022 | 10:27h | UTCComparing methotrexate monotherapy with methotrexate plus leflunomide combination therapy in psoriatic arthritis (COMPLETE-PsA): a double-blind, placebo-controlled, randomised, trial – The Lancet Rheumatology (link to abstract – $ for full-text)
Commentary: COMPLETE-PsA: Adding leflunomide to methotrexate may improve outcomes – medwireNews
Commentary on Twitter
NEW RESEARCH—A double-blind, placebo-controlled, randomised, trial comparing #methotrexate monotherapy with methotrexate plus #leflunomide combination therapy in psoriatic arthritis (COMPLETE-PsA) https://t.co/Fln7RlNl36 #LancetRheumatology pic.twitter.com/EqWSeHZQA2
— The Lancet Rheumatology (@TheLancetRheum) March 3, 2022
Medication-taking for secondary prevention of acute myocardial infarction: a thematic meta-synthesis of patient experiences.
10 Mar, 2022 | 10:24h | UTC
Glycated hemoglobin and the risk of postoperative complications in people without diabetes: a prospective population-based study in UK Biobank.
10 Mar, 2022 | 10:22h | UTC
Feasibility of discharge within 72 hours of major colorectal surgery: lessons learned after 5 years of institutional experience with the ERAS protocol.
10 Mar, 2022 | 10:21h | UTCRelated:
ERAS Guidelines for Perioperative Care in Elective Colorectal Surgery
Review: Enhanced Recovery After Surgery in Emergency Colorectal Surgery
Commentary on Twitter
A five year #retrospective #cohort study explored link between early post-op discharge and #ERAS (n=965)
-> adherence to >80% ERAS components associated with early discharge. Long operations, drains, and complications assoc w/longer stays.https://t.co/2nXBrKbg5D#SoMe4Surgery pic.twitter.com/h5P4YFC8zh
— BJS Open (@BjsOpen) March 2, 2022
M-A: Ketorolac administration after colorectal surgery may increase anastomotic leak rate.
10 Mar, 2022 | 10:19h | UTC
Mapping systematic reviews of breast cancer survivorship interventions.
10 Mar, 2022 | 10:16h | UTC
Commentary on Twitter
? Despite vast volume, review-level #BreastCancer #survivorship research is unevenly distributed and siloed. Strategic planning of future research, in consultation with survivors, is needed. ➡️ https://t.co/pxMp5XK8B8 #JCO #BCSM @EmmaBKemp1 #survonc pic.twitter.com/TRjOEJQbrw
— Journal of Clinical Oncology (@JCO_ASCO) March 5, 2022
Perspective: The time toxicity of cancer treatment.
10 Mar, 2022 | 10:15h | UTCThe Time Toxicity of Cancer Treatment – Journal of Clinical Oncology