Daily Archives: February 13, 2022 | LinksMedicus Free Medical News & Perspectives

In November 2021 WHO designated omicron a variant of concern. With its sublineage BA.2 now widespread, @emahase_ looks at what science has found out about the variant and its three (so far) variations https://t.co/HjBZSwCATW

— The BMJ (@bmj_latest) February 13, 2022

Conflicting reports raise questions about whether any monoclonals work against Omicron’s sister variant.

13 Feb, 2022 | 22:49h | UTC

Conflicting reports raise questions about whether any monoclonals work against Omicron’s sister variant – STAT

FDA halts use of antibody drugs that don’t work vs. Omicron.

Lab study shows new antiviral pills maintain efficacy against Omicron, but antibody drugs are substantially less effective.

ERS statement on Long COVID-19 follow-up.

13 Feb, 2022 | 22:48h | UTC

European Respiratory Society Statement on Long COVID-19 Follow-Up – European Respiratory Review

First research definition for ‘Long COVID’ in kids and young people formally agreed.

13 Feb, 2022 | 22:45h | UTC

News Release: First research definition for ‘Long COVID’ in kids and young people formally agreed – BMJ

Original Article (preprint): Long COVID (Post-COVID-19 condition) in Children: a modified Delphi Process – Archives of Disease in Childhood

Commentaries:

Expert reaction to Delphi consensus study on a long-COVID definition in children – Science Media Centre

Long covid: “Holistic” approach is best, given range of symptoms, say researchers – The BMJ

Cohort Study: Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England.

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

E ditorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Special Issue: Evidence-based strategies for better antibiotic prescribing in primary care.

13 Feb, 2022 | 22:40h | UTC

Editorial: Antibiotic stewardship – Australian Journal of General Practice

Antibiotic stewardship: A review of successful, evidence-based primary care strategies – Australian Journal of General Practice

Evidence-based strategies for better antibiotic prescribing – Australian Journal of General Practice

How can general practitioners reduce antibiotic prescribing in collaboration with their patients? – Australian Journal of General Practice

RCT: Effects of a 6-month, low-carbohydrate diet on glycemic control, body composition, and cardiovascular risk factors in patients with type 2 diabetes.

13 Feb, 2022 | 22:35h | UTC

Effects of a 6-month, low-carbohydrate diet on glycaemic control, body composition, and cardiovascular risk factors in patients with type 2 diabetes: An open-label randomized controlled trial – Diabetes, Obesity and Metabolism

RCT: Primary Norfloxacin prophylaxis prevents bacterial infections in patients with acute-on-chronic liver failure.

13 Feb, 2022 | 22:37h | UTC

Primary Norfloxacin Prophylaxis for APASL-Defined Acute-on-Chronic Liver Failure: A Placebo-Controlled Double-Blind Randomized Trial – The American Journal of Gastroenterology (link to abstract – $ for full-text)

WHO Guideline: Hypertension pharmacological treatment in adults.

13 Feb, 2022 | 22:23h | UTC

Hypertension Pharmacological Treatment in Adults: A World Health Organization Guideline Executive Summary – Hypertension

2022 SCCM Guidelines on prevention and management of pain, agitation, neuromuscular blockade, and delirium in critically ill pediatric patients with consideration of the ICU environment and early mobility.

13 Feb, 2022 | 22:19h | UTC

2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients With Consideration of the ICU Environment and Early Mobility – Pediatric Critical Care Medicine

Commentary on Twitter

New in #PANDEM guidelines for infants & children: guidance on nonpharmacological interventions that can lead to better outcomes:
✅ Music
✅ Physical
✅ Occupational
✅ Child life
What interventions have worked well for you?
Guidelines: https://t.co/lMfFsiEPeV #SCCMSoMe #PedsICU pic.twitter.com/BLksVV0pNo

— SCCM (@SCCM) February 4, 2022

AAST Consensus: Rhabdomyolysis.

13 Feb, 2022 | 22:21h | UTC

Rhabdomyolysis: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document – Trauma Surgery & Acute Care Open

FIMS / EFSMA Joint position statement on the International Olympic Committee framework on fairness, inclusion and non-discrimination based on gender identity and sex variations.

13 Feb, 2022 | 22:17h | UTC

Joint position statement of the International Federation of Sports Medicine (FIMS) and European Federation of Sports Medicine Associations (EFSMA) on the IOC framework on fairness, inclusion and non-discrimination based on gender identity and sex variations – BMJ Open Sport & Exercise Medicine

Original Guidance: IOC Framework on fairness, inclusion and non-discrimination on the basis of gender identity and sex variations – International Olympic Committee

Commentary: International Olympic Committee transgender guidance criticised by medical experts – BBC

Commentary on Twitter

You do not have to agree with all content in this position statement. But surely we can agree that we need further debate and discussion (and consultation with all stakeholders) to protect the rights of all athletes. #OpenAccess ➡️ https://t.co/xIfnsyk7FV #Diversity #Inclusion pic.twitter.com/2c9S8lGCoa

— BMJ Open Sport & Exercise Medicine (@BMJOpenSEM) January 20, 2022

RCT: In patients with cardiogenic shock receiving VA-ECMO, moderate hypothermia did not significantly reduce 30-day mortality. 42% of patients in the moderate hypothermia group died vs. 51% in the normothermia group (adjusted odds ratio, 0.71 [95% CI, 0.45 to 1.13], P = .15).

13 Feb, 2022 | 22:11h | UTC

Effect of Moderate Hypothermia vs Normothermia on 30-Day Mortality in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: Hypothermia vs. Normothermia for Cardiogenic Shock Patients on VA-ECMO – American College of Cardiology

Commentary on Twitter

In this RCT, for patients with cardiogenic shock receiving venoarterial ECMO, moderate hypothermia for 24 hours compared with normothermia did not significantly decrease 30-day mortality. https://t.co/0LKYJ1bNB3 pic.twitter.com/KmXPAlvqh9

— JAMA (@JAMA_current) February 2, 2022

RCT: In patients with contaminated ventral hernias undergoing repair, synthetic Mesh reduced hernia recurrence risk compared with biologic Mesh.

13 Feb, 2022 | 22:05h | UTC

Biologic vs Synthetic Mesh for Single-stage Repair of Contaminated Ventral Hernias: A Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)

Commentary on Twitter

Multicenter randomized clinical trial found synthetic mesh demonstrated significantly lower hernia recurrence risk than biologic mesh in patients undergoing single-stage repair of clean-contaminated and contaminated ventral hernias. https://t.co/CADZPSYGBc

— JAMA Surgery (@JAMASurgery) January 19, 2022

Opinion | There’s no autism epidemic. But there is an autism diagnosis epidemic.

13 Feb, 2022 | 22:02h | UTC

There’s no autism epidemic. But there is an autism diagnosis epidemic – STAT

Opinion: Time to retire the concept of Transient Ischemic Attack.

13 Feb, 2022 | 22:01h | UTC

Time to Retire the Concept of Transient Ischemic Attack – JAMA (free for a limited period)

Commentary on Twitter

After spending my entire career studying TIAs, Don Easton and I are recommending we retire the term. It isn't clear that TIAs ever existed, at least as they were conceptualized. Rise up Acute Ischemic Cerebrovascular Event/Syndrome. https://t.co/FeG31pPHey

— Clay Johnston (@ClayJohnstonMD) February 11, 2022

Sleep assessment in critically ill adults: established methods and emerging strategies.

13 Feb, 2022 | 21:55h | UTC

Sleep Assessment in Critically Ill Adults: Established Methods and Emerging Strategies – Critical Care Explorations

Commentary on Twitter

#CritCareExplore @SCCM Critically ill patients sleep poorly while in the ICU with potential implications for several important outcomes. This review summarizes both current methods and new strategies to measure sleep in these challenging environments. https://t.co/2jtpHe4MKp pic.twitter.com/c5jnqwR3Mh

— Critical Care Explorations (@CritCareExplore) February 12, 2022

Study shows a lack of association of Group A Streptococcal infections and onset of tics.

13 Feb, 2022 | 22:04h | UTC

Lack of Association of Group A Streptococcal Infections and Onset of Tics: European Multicenter Tics in Children Study – Neurology (link to abstract – $ for full-text)

News Release: Does strep throat lead to the development of tics? – American Academy of Neurology

Commentaries:

Strep Does Not Lead to Tics, Study Finds – NeurologyToday

Group A Strep Infection Not Tied to Tics in Children With Family History – HealthDay

Commentary on Twitter

Very important study to further remove us away from Group-A streptococcal infections and tics in families with primary tic disorders! https://t.co/HwHVrxNSqJ

— Christos Ganos (@ChristosGanos) February 9, 2022

Review: Management of venous thromboembolism in pregnancy.

13 Feb, 2022 | 21:57h | UTC

Management of venous thromboembolism in pregnancy – Thrombosis Research

Management of high-risk pulmonary embolism in pregnancy.

Study: Diagnosis of Pulmonary Embolism During Pregnancy

Imaging is the only way to diagnose blood clots in pregnancy

Prevention and Treatment of Pregnancy-Associated Venous Thromboembolism: Critical Appraisal of International Guidelines

ED management of the post-laryngectomy patient.

13 Feb, 2022 | 21:44h | UTC

ED Management of the Post-Laryngectomy Patient – emDocs

Review: Global accessibility of therapeutics for diabetes mellitus.

13 Feb, 2022 | 21:51h | UTC

Global accessibility of therapeutics for diabetes mellitus – Nature Reviews Endocrinology (if the link is paywalled, try this one)

New WHO report maps barriers to insulin availability and suggests actions to promote universal access – “100 years after its discovery, insulin still out of reach for many living with diabetes”.

Editorial | Insulin for all: a hope yet to be realized.

One hundred years of insulin therapy.

The state of diabetes treatment coverage in 55 low-income and middle-income countries – fewer than one in ten people with diabetes in LMICs receive comprehensive care such as low-cost medicines to reduce blood sugar, blood pressure and cholesterol levels, in addition to counseling on diet, exercise and weight.

Betibeglogene Autotemcel gene therapy for Non–beta0/beta0 Genotype beta-thalassemia.

13 Feb, 2022 | 21:46h | UTC

Betibeglogene Autotemcel Gene Therapy for Non–β⁰/β⁰ Genotype β-Thalassemia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary on Twitter

Visual Abstract: Betibeglogene Autotemcel Gene Therapy for Non–β0/β0 Genotype β-Thalassemia. https://t.co/2GOCGxrruv pic.twitter.com/zLvuuuByXN

— NEJM (@NEJM) February 8, 2022