Daily Archives: February 2, 2022 | LinksMedicus Free Medical News & Perspectives

Outpatient Therapies for COVID-19: How do we choose?

2 Feb, 2022 | 08:53h | UTC

Outpatient Therapies for COVID-19: How do we choose? – Open Forum Infectious Diseases

WHO Report: Global analysis of health care waste in the context of COVID-19.

2 Feb, 2022 | 08:54h | UTC

Global analysis of health care waste in the context of COVID-19 – World Health Organization

News Release: Tonnes of COVID-19 health care waste expose urgent need to improve waste management systems – World Health Organization

Commentaries:

Covid-19: Pandemic waste threatens human and environmental health, says WHO – The BMJ

Amid Mountains of COVID Waste, WHO Urges Sustainable Solutions – Health Policy Watch

Commentary on Twitter (thread – click for more)

The #COVID19 pandemic has generated extra tonnes of waste & exposed cracks in waste management, everywhere.
Waste must be reduced & managed safely, for the health of both people & the environment https://t.co/JsYeqvl7G6 pic.twitter.com/UfI0GRjBD1

— World Health Organization (WHO) (@WHO) February 1, 2022

Updated NIH COVID-19 Treatment Guidelines: Therapeutic management of nonhospitalized adults with COVID-19.

2 Feb, 2022 | 08:50h | UTC

Therapeutic Management of Nonhospitalized Adults With COVID-19 – NIH COVID-19 Treatment Guidelines

Commentary on Twitter

NIH update??
Therapeutic Management of Nonhospitalized Adults With #COVID19 #TwitteRx #medtwitter #TwitteRx #MedEd https://t.co/QpKsVJArUj pic.twitter.com/HKb81dB5b8

— Antibiotic Stewa®️x? Bassam Ghanem (@ABsteward) February 1, 2022

Editorial: Menstruation and Covid-19 vaccination.

2 Feb, 2022 | 08:46h | UTC

Menstruation and covid-19 vaccination – The BMJ

News Release: New studies provide reassuring data on menstrual changes after covid-19 vaccination – BMJ

Commentary on Twitter

The findings from two new studies are reassuring: "changes to the menstrual cycle do occur following vaccination, but they are small compared with natural variation and quickly reverse"https://t.co/QFZ4I1U6yd

— The BMJ (@bmj_latest) January 28, 2022

Ten billion COVID vaccinations: world hits new milestone.

2 Feb, 2022 | 08:48h | UTC

Ten billion COVID vaccinations: world hits new milestone – Nature

Commentary on Twitter

10 billion doses given, <1 billion were boosters
1 continent nearly left outhttps://t.co/DrCqQ4b7tJ
and @OurWorldInData

“It is a huge scientific achievement that ten billion doses of vaccines to a new pathogen were developed in two years from its identification”—@doctorsoumya pic.twitter.com/pyLXlvI22Q

— Eric Topol (@EricTopol) February 1, 2022

As Denmark scraps COVID restrictions, WHO urges caution.

2 Feb, 2022 | 08:47h | UTC

As Denmark Scraps COVID Restrictions, WHO Urges Caution – Health Policy Watch

M-A: Impact of Ketamine on analgosedative consumption in critically ill patients.

2 Feb, 2022 | 08:44h | UTC

Impact of Ketamine on Analgosedative Consumption in Critically Ill Patients: A Systematic Review and Meta-Analysis – Annals of Pharmacotherapy

RCT: Fentanyl vs. placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department.

RCT: In patients undergoing emergency endotracheal intubation, 7-day survival was significantly lower with etomidate vs. ketamine (77.3% versus 85.1%), but 28 survival rates were not significantly different (etomidate 64.1% vs. ketamine 66.8%, p = 0.294).

Perspective: Avoidance of β-blockers in patients who use stimulants is not supported by good evidence.

2 Feb, 2022 | 08:39h | UTC

Avoidance of β-blockers in patients who use stimulants is not supported by good evidence – Canadian Medical Association Journal

Perspective: The ongoing saga of normal saline vs. balanced fluids.

2 Feb, 2022 | 08:43h | UTC

The ongoing saga of normal saline versus balanced fluids – First10EM

Original studies:

RCT: In critically ill adults, using a balanced multielectrolyte solution did not lower the risk of death or acute kidney injury compared to standard saline.

Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis – NEJM Evidence

BaSICS RCT: Among critically ill patients requiring fluid therapy, treatment with a balanced solution did not lead to reduced mortality compared to a 0.9% saline solution.

BaSICS RCT: Among critically ill patients requiring fluid therapy, there was no difference in mortality with slower (333 mL/h) vs. faster (999 mL/h) intravenous fluid bolus rates.

Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline

Using melatonin for sleep is on the rise, study says, despite potential health harms.

2 Feb, 2022 | 08:41h | UTC

Using melatonin for sleep is on the rise, study says, despite potential health harms – CNN

Original Study: Trends in Use of Melatonin Supplements Among US Adults, 1999-2018 – JAMA (free for a limited period)

Cohort Study: Association of posttraumatic epilepsy with 1-year outcomes after traumatic brain injury.

2 Feb, 2022 | 08:36h | UTC

Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury – JAMA Network Open

Commentary on Twitter

In this cohort study, the incidence of self-reported posttraumatic #epilepsy after traumatic brain injury (TBI) was associated with unfavorable outcomes, highlighting the need to find effective antiepileptogenic therapies after #TBI. #PTE #TRACKTBI https://t.co/mxfd7oVQFN

— JAMA Network Open (@JAMANetworkOpen) December 29, 2021

Cluster Randomized Trial: In older patients undergoing elective surgical procedures, a multimodal nonpharmacological prevention program reduced postoperative delirium occurrence and days with delirium.

2 Feb, 2022 | 08:38h | UTC

Outcomes of a Delirium Prevention Program in Older Persons After Elective Surgery: A Stepped-Wedge Cluster Randomized Clinical Trial – JAMA Surgery

Author Interview: Effective Delirium Prevention in Older Persons After Elective Surgery

Commentary on Twitter

Study suggests implementing a multifaceted multidisciplinary prevention intervention will improve care and outcomes in older patients undergoing elective general and orthopedic procedures https://t.co/lHU59ca5m5 pic.twitter.com/oj76KiV4It

— JAMA Surgery (@JAMASurgery) December 15, 2021

RCT: Safety and efficacy of agomelatine in children and adolescents with major depressive disorder receiving psychosocial counselling.

2 Feb, 2022 | 08:34h | UTC

Safety and efficacy of agomelatine in children and adolescents with major depressive disorder receiving psychosocial counselling: a double-blind, randomised, controlled, phase 3 trial in nine countries – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentary on Twitter

RCT: 10 to 25 mg/day agomelatine resulted in an improvement versus placebo in CDRS-R raw score of 4·22 (0·63–7·82) at 12 weeks in C&A with MDD, with a similar effect for fluoxetine. The overall effect was confirmed in adolescents, but not in children https://t.co/keecz57fQw

— PfOL (@psychopharmacol) December 23, 2021

NCCN Guideline: Kidney Cancer.

2 Feb, 2022 | 08:30h | UTC

Kidney Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network

Review: Primary and metastatic peritoneal surface malignancies.

2 Feb, 2022 | 08:33h | UTC

Primary and metastatic peritoneal surface malignancies – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Primary and metastatic peritoneal surface malignancies – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Commentary on Twitter

Treatment modalities for #peritoneal surface malignancies can be combined or used sequentially according to underlying #tumour type, disease extent and patients' condition and preference.https://t.co/cIkVAJRSaj pic.twitter.com/PUP1BtoTxE

— Nature Reviews Disease Primers (@DiseasePrimers) December 21, 2021

Takotsubo Syndrome: A review of presentation, diagnosis and management.

2 Feb, 2022 | 08:25h | UTC

Takotsubo Syndrome: A Review of Presentation, Diagnosis and Management – Clinical Medicine Insights: Cardiology

Middle-aged and older women are being diagnosed with Takotsubo Syndrome more frequently, up to 10 times more often, than younger women or men of any age.

International Expert Consensus Document on Takotsubo Syndrome

International Registry: 16.6% of Patients with Takotsubo Syndrome Have Underlying Malignancy

Systematic Review: Long-Term Prognosis and Outcome Predictors in Takotsubo Syndrome

Cohort Study: Hospital Readmission Following Takotsubo Syndrome

RCT: 2 L polyethylene glycol plus ascorbic acid may provide similar efficacy and better tolerability as 4 L polyethylene glycol for bowel cleansing in elderly patients aged 60–79.

2 Feb, 2022 | 08:29h | UTC

Comparison of 2 L Polyethylene Glycol Plus Ascorbic Acid and 4 L Polyethylene Glycol in Elderly Patients Aged 60–79: A Prospective Randomized Study – Digestive Diseases and Sciences (link to abstract – $ for full-text)

Related Guidelines:

Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2019 – Endoscopy

Bowel preparation before colonoscopy – Gastrointestinal Endoscopy

DIC in Pregnancy: Pathophysiology, clinical characteristics, diagnostic scores, and treatments.

2 Feb, 2022 | 08:27h | UTC

DIC in Pregnancy – Pathophysiology, Clinical Characteristics, Diagnostic Scores, and Treatments – Journal of Blood Medicine

RCT: Efficacy and safety of Risankizumab for active psoriatic arthritis.

2 Feb, 2022 | 08:23h | UTC

Efficacy and safety of risankizumab for active psoriatic arthritis: 24-week results from the randomised, double-blind, phase 3 KEEPsAKE 1 trial – Annals of Rheumatic Diseases

Residual cancer burden after neoadjuvant chemotherapy and long-term survival outcomes in breast cancer: a multicenter pooled analysis of 5161 patients.

2 Feb, 2022 | 08:22h | UTC

Residual cancer burden after neoadjuvant chemotherapy and long-term survival outcomes in breast cancer: a multicentre pooled analysis of 5161 patients – The Lancet Oncology

Commentary: Long-Term Outcomes According to Residual Cancer Burden After Neoadjuvant Chemotherapy for Breast Cancer – The ASCO Post

Short Review | Hypersensitivity reactions to vaccines in children: from measles to SARS-CoV-2.

2 Feb, 2022 | 08:13h | UTC

Hypersensitivity reactions to vaccines in children: from measles to SARS-CoV-2 – Pediatric Allergy and Immunology

Commentary: Vaccine hypersensitivity in children – News Medical

M-A: Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis.

2 Feb, 2022 | 08:20h | UTC

Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: Review finds upadacitinib most effective for moderate to severe ulcerative colitis remission – ACP Gastroenterology

M-A: Birth outcomes of neonates exposed to marijuana in utero.

2 Feb, 2022 | 08:19h | UTC

Birth Outcomes of Neonates Exposed to Marijuana in Utero: A Systematic Review and Meta-analysis – JAMA Network Open

Invited commentary: Reexamining Risks of Prenatal Cannabis Use—Mounting Evidence and a Call to Action – JAMA Network Open

Commentary on Twitter

This systematic review and meta-analysis found that prenatal marijuana exposure is associated with increases in many adverse neonatal outcomes, including lower birth weight and preterm delivery. @MarchandSurgery @tmcaznews https://t.co/qvWOWu4Dkc

— JAMA Network Open (@JAMANetworkOpen) January 27, 2022