Daily Archives: January 21, 2022
Opinion: COVID-19 will continue but the end of the pandemic is near.
21 Jan, 2022 | 10:16h | UTCCOVID-19 will continue but the end of the pandemic is near – The Lancet
Commentary on Twitter
.@IHME_UW's Chris Murray predicting the end of the pandemic is nigh
"More than 50% of the world will have been infected with omicron …[by] the end of March, 2022"
"After the omicron wave, COVID-19 will return but the pandemic will not."https://t.co/9NSw8lZuUe @TheLancet— Eric Topol (@EricTopol) January 20, 2022
RCT: Immunogenicity and reactogenicity of different vaccine boosters after a first J&J vaccine.
21 Jan, 2022 | 10:12h | UTC
Commentary on Twitter
Trial examined effects of boosting with one of the three approved #COVI19 vaccines — AD26.COV2.S, mRNA-1273, or BNT162b2 — 3 mos after the primary vaccination. All increased neutralizing-antibody levels & T-cell responses; mRNA vaccines were higher. https://t.co/qkpQFvNliJ pic.twitter.com/MUfa1OEsLP
— NEJM (@NEJM) January 19, 2022
Opinion: Now that science has defanged Covid, it’s time to get on with our lives.
21 Jan, 2022 | 10:14h | UTCNow that science has defanged Covid, it’s time to get on with our lives – The Guardian
See also: A National Strategy for the “New Normal” of Life With COVID – JAMA
Perspective: Nervous system consequences of COVID-19.
21 Jan, 2022 | 10:10h | UTCNervous system consequences of COVID-19 – Science
Related:
Review: Counting the neurological cost of COVID-19.
Neurological Effects of COVID-19 in Children.
International Registry: Ischemic and hemorrhagic stroke among critically ill patients with Covid-19.
Short review: Neurological complications of COVID-19.
2 new meta-analysis detail neurologic and psychiatric conditions in COVID-19.
M-A: Encephalitis as Neurological Complication of COVID‐19.
Large study finds 1 in 3 Covid-19 survivors have subsequent mental health and neurological conditionsEight out of ten people hospitalized with COVID-19 develop neurological problems – the most common self-reported symptoms included headache (37%) and anosmia or ageusia (26%).
Commentary on Twitter
A new #SciencePerspective discusses the neurological symptoms that accompany #COVID19 and the possible mechanisms that cause them. Read more: https://t.co/WKZpnWlbNc pic.twitter.com/U4ohecaVQd
— Science Magazine (@ScienceMagazine) January 20, 2022
Review: Postdischarge Evaluation for Individuals Hospitalized with COVID-19.
21 Jan, 2022 | 10:08h | UTCPostdischarge Evaluation for Individuals Hospitalized with COVID-19 – Southern Medical Journal
Europe considers new COVID-19 strategy: Accepting the virus.
21 Jan, 2022 | 10:13h | UTCEurope considers new COVID-19 strategy: Accepting the virus – Associated Press
[Preprint] COVID infection severity in children under 5 years old before and after Omicron emergence in the US.
21 Jan, 2022 | 10:04h | UTCCommentary: SARS-CoV-2 Omicron infections milder in children compared to Delta – News Medical
Editorial | Covid-19 vaccines and treatments: we must have raw data, now.
21 Jan, 2022 | 10:00h | UTCCovid-19 vaccines and treatments: we must have raw data, now – The BMJ
News Release: Editors call for covid-19 vaccine and treatment data to be available for public scrutiny – The BMJ
WHO’s Emergencies expert group re-asserts stance against covid ‘vaccine passports’ for international travel.
21 Jan, 2022 | 10:02h | UTC
Editorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.
21 Jan, 2022 | 09:58h | UTCLong covid in children and adolescents – The BMJ
Related:
Review: Long COVID symptoms in children rarely persist beyond three months.
Cohort study: Risk factors for long covid in previously hospitalized children.
M-A: More than 50 long-term effects of COVID-19.
Commentary on Twitter
"As SARS-CoV-2 remains predominantly a mild infection in the paediatric population, the incidence of long covid is a critical factor in the risk-benefit equation for policy and parental decisions on covid-19 vaccines for children," says Editorialhttps://t.co/POidCyS2RZ
— The BMJ (@bmj_latest) January 20, 2022
Perioperative guidelines on antiplatelet and anticoagulant agents: 2022 Update.
21 Jan, 2022 | 09:53h | UTC
RCT: Metal pins no better than traditional plaster cast for a broken wrist.
21 Jan, 2022 | 09:51h | UTCNews Release: Metal pins no better than traditional plaster cast for a broken wrist – BMJ
Original Study: Surgical fixation with K-wires versus casting in adults with fracture of distal radius: DRAFFT2 multicentre randomised clinical trial – The BMJ
Commentary: Wrist fractures: study compares casting to surgical fixation – MedicalResearch.com
Commentary on Twitter
Fascinating to read the results of #DRAFFT2 in the BMJ. Lots to think about: No difference in wrist function at 12 months but higher reoperation rate for loss of position in cast-only group (13% v 0.4%) #orthotwitter https://t.co/QJO43XBdB6 pic.twitter.com/IMCpcsoiSh
— Tom Lewis (@thomasllewis) January 20, 2022
ATS Guideline: Outpatient respiratory management of infants, children, and adolescents with post-prematurity respiratory disease.
21 Jan, 2022 | 09:55h | UTC
RCT: Lenvatinib plus pembrolizumab improve outcomes compared to chemotherapy in patients with advanced endometrial cancer.
21 Jan, 2022 | 09:46h | UTCLenvatinib plus Pembrolizumab for Advanced Endometrial Cancer – New England Journal of Medicine
Commentary on Twitter
In women with advanced endometrial cancer, the median progression-free survival was 7.2 months with lenvatinib plus pembrolizumab and 3.8 months with chemotherapy; the median overall survival was 18.3 months and 11.4 months, respectively. https://t.co/lzqFDnhAQn pic.twitter.com/Tm2BJZuh1D
— NEJM (@NEJM) January 19, 2022
Review: Diagnostic evaluation of gastric motor and sensory disorders.
21 Jan, 2022 | 09:42h | UTCDiagnostic Evaluation of Gastric Motor and Sensory Disorders – American Journal of Gastroenterology
Cohort Study: Among patients with resolved Hepatitis B infections and concomitant autoimmune disease, exposure to prednisone doses greater than 20 mg/day were associated with a high risk for HBV reactivation or hepatitis flare.
21 Jan, 2022 | 09:39h | UTCAverage corticosteroid dose and risk for HBV reactivation and hepatitis flare in patients with resolved hepatitis B infection – Annals of Rheumatic Disease (link to abstract – $ for full-text)
Commentary on Twitter
Patients with time-weighted average prednisone dose greater than 20 mg/day would be classified as the high risk for HBV reactivation or hepatitis flare. Prophylactic Anti-HBV therapy may be needed for these high-risk patientshttps://t.co/qLuirdyXDK pic.twitter.com/yDJ4c072qm
— ARD & RMD Open (@ARD_BMJ) December 23, 2021
Systematic Review: In people with Alzheimer’s disease and vascular dementia with agitation and psychosis, atypical antipsychotics probably reduce agitation slightly (moderate‐certainty evidence) but probably have a negligible effect on psychosis or risk of any adverse event.
21 Jan, 2022 | 09:50h | UTC
Sleeping on the LEFT side seems to be associated with reduced nocturnal acid exposure compared with supine and right lateral decubitus positions.
21 Jan, 2022 | 09:45h | UTCAssociations Between Sleep Position and Nocturnal Gastroesophageal Reflux: A Study Using Concurrent Monitoring of Sleep Position and Esophageal pH and Impedance – American Journal of Gastroenterology (link to abstract – $ for full-text)
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
21 Jan, 2022 | 09:36h | UTCTreatment for Brain Metastases: ASCO-SNO-ASTRO Guideline – Journal of Clinical Oncology
15th Report on Carcinogens now includes 256 listings of substances that are known or reasonably anticipated to cause cancer in humans.
21 Jan, 2022 | 09:34h | UTC15th Report on Carcinogens – National Toxicology Program
Commentary on Twitter
8 substances have been added to the 15th report on Carcinogens, bringing the total list to 256 substances that are known, or reasonably anticipated, to cause cancer in humanshttps://t.co/r1e9Bv8hIU pic.twitter.com/BVGt809g2T
— K Pavithran (@drkpavithran) December 23, 2021
Is precision public health the future — or a contradiction?
21 Jan, 2022 | 09:31h | UTCIs precision public health the future — or a contradiction? – Nature
M-A: No difference in outcomes with Beta-lactam monotherapy vs. combination therapy for bloodstream infections or pneumonia due to P. aeruginosa.
21 Jan, 2022 | 09:37h | UTCBeta-lactam monotherapy or combination therapy for bloodstream infections or pneumonia due to P. aeruginosa: a meta-analysis – International Journal of Antimicrobial Agents (link to abstract – $ for full-text)
The validity of progression-free survival 2 as a surrogate trial end point for overall survival.
21 Jan, 2022 | 09:31h | UTCThe validity of progression-free survival 2 as a surrogate trial end point for overall survival – Cancer (link to abstract – $ for full-text)
M-A: In patients with acute coronary syndrome, a guided approach (i.e., platelet function or genetic testing) to P2Y12 inhibiting therapy may reduce major adverse cardiovascular events without increased risk of bleeding.
21 Jan, 2022 | 09:33h | UTCComparative effects of guided vs. potent P2Y12 inhibitor therapy in acute coronary syndrome: a network meta-analysis of 61 898 patients from 15 randomized trials – European Heart Journal (link to abstract – $ for full-text)
Commentary: Another Win for Guided P2Y12 Therapy in ACS: Meta-analysis – TCTMD
Commentary on Twitter
Comparative effects of guided vs. potent P2Y12 inhibitor therapy in acute coronary syndrome: a network meta-analysis of 61 898 patients from 15 randomized trials: read more in EHJ!https://t.co/oAehSfPVdt#cardiotwitter @ESC_Journals @escardio pic.twitter.com/AEuH7V6IkR
— EHJ Editor-in-Chief (@ehj_ed) December 23, 2021
RCT: In patients with previously untreated Diffuse Large B-Cell Lymphoma, a modified regimen of R-CHOP (pola-R-CHP), in which vincristine was replaced with polatuzumab, was associated with improved outcomes compared to standard R-CHOP treatment.
21 Jan, 2022 | 09:28h | UTCPolatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma – New England Journal of Medicine (link to abstract – $ for full-text)