Daily Archives: January 13, 2022
Observational study in adolescents showed the Pfizer-BioNTech vaccine had an overall effectiveness of 94% against hospitalization and 98% against critical Covid-19.
13 Jan, 2022 | 09:00h | UTCEditorial: Sparing of Severe Covid-19 in Vaccinated Adolescents – New England Journal of Medicine
Study shows COVID-19 vaccines offer lasting protection against hospitalization and death.
13 Jan, 2022 | 09:01h | UTCNews Release: Study shows COVID-19 vaccines offer lasting protection – University of North Carolina at Chapel Hill
An observational study in South Africa estimates the Pfizer vaccine had an effectiveness of 70% against hospitalization for Covid-19 caused by the omicron variant.
13 Jan, 2022 | 08:56h | UTCCommentary: BNT162b2 still effective, but less so, against Omicron – HealthDay
The COVID generation: how is the pandemic affecting kids’ brains?
13 Jan, 2022 | 08:53h | UTCThe COVID generation: how is the pandemic affecting kids’ brains? – Nature
Omicron Infection Curve ‘Staggering’ – 36 Countries Have Vaccinated Less than 10% of Citizens.
13 Jan, 2022 | 08:49h | UTC
RCT: Early Remdesivir in outpatients can prevent progression to severe Covid-19.
13 Jan, 2022 | 08:54h | UTCEditorial: The Goldilocks Time for Remdesivir — Is Any Indication Just Right?
Commentary: Three days of remdesivir cuts risk for severe COVID-19 in outpatients – MedicalXpress
Commentary on Twitter
Among nonhospitalized patients with Covid-19–related symptoms, a 3-day course of remdesivir resulted in an 87% lower risk of hospitalization or death than placebo. #COVID19 #IDTwitter https://t.co/YFflw5nBxB pic.twitter.com/4NCD9AcnYH
— NEJM (@NEJM) December 22, 2021
Another study showed neutralizing monoclonal antibody therapies are not effective when given after the patient is already hospitalized.
13 Jan, 2022 | 08:48h | UTCInvited Commentary: Time to knock monoclonal antibodies off the platform for patients hospitalised with COVID-19
‘Killer’ immune cells still recognize Omicron variant.
13 Jan, 2022 | 08:51h | UTC‘Killer’ immune cells still recognize Omicron variant – Nature
See also: T-cells: the superheroes in the battle against omicron – The Conversation
RCT: A single dose of a novel adenovirus type 5 vectored SARS-CoV-2 vaccine was safe and had 57.5% efficacy against symptomatic Covid-19 and 91.7% efficacy against severe disease in adults.
13 Jan, 2022 | 08:44h | UTCCommentaries:
Efficacy of an adenovirus type 5 vectored SARS-CoV-2 vaccine – The Lancet
A clinical case definition of post-COVID-19 condition by a Delphi consensus.
13 Jan, 2022 | 08:45h | UTC
Commentary on Twitter
New Review: A clinical case definition of post-#COVID19 condition by a Delphi consensus https://t.co/AoWBgCeMq5 pic.twitter.com/kAW1YY6kgr
— The Lancet Infectious Diseases (@TheLancetInfDis) December 22, 2021
RCT: Pancreatoduodenectomy with or without prophylactic falciform ligament wrap around the hepatic artery for prevention of postpancreatectomy haemorrhage.
13 Jan, 2022 | 08:35h | UTCPancreatoduodenectomy with or without prophylactic falciform ligament wrap around the hepatic artery for prevention of postpancreatectomy haemorrhage: randomized clinical trial (PANDA trial) – British Journal of Surgery (link to abstract – $ for full-text)
Commentary on Twitter
In Jan's BJS: Pancreatoduodenectomy with/without prophylactic falciform ligament wrap around hepatic artery: PANDA trial https://t.co/itf6rQsxMP @AmyLightnerMD @bplwijn @des_winter @ksoreide @MalinASund @evanscolorectal @nfmkok @robhinchliffe1 @young_bjs pic.twitter.com/YpBocbplUn
— BJS (@BJSurgery) January 11, 2022
Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.
13 Jan, 2022 | 08:42h | UTCInvited Commentary: The true global disease burden of mental illness: still elusive – The Lancet Psychiatry (free registration required)
Review: Diagnosis and treatment of sexually transmitted infections.
13 Jan, 2022 | 08:38h | UTCDiagnosis and Treatment of Sexually Transmitted Infections: A Review – JAMA (free for a limited period)
Cohort Study: Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis – the presence of an appendicolith was associated with a nearly 2-fold increased risk of undergoing appendectomy within 30 days.
13 Jan, 2022 | 08:39h | UTCPatient Factors Associated With Appendectomy Within 30 Days of Initiating Antibiotic Treatment for Appendicitis – JAMA Surgery (free for a limited period)
Invited commentary: Appendicoliths, Antibiotic Treatment Failure, and Appendectomy—Is the Glass Half Full or Half Empty? – JAMA Surgery
Review: Bowel decontamination before colonic and rectal surgery.
13 Jan, 2022 | 08:36h | UTCBowel decontamination before colonic and rectal surgery – British Journal of Surgery
The year in cardiovascular medicine 2021: valvular heart disease.
13 Jan, 2022 | 08:34h | UTCThe year in cardiovascular medicine 2021: valvular heart disease – European Heart Journal
The year in cardiovascular medicine 2021: diabetes and metabolic disorders.
13 Jan, 2022 | 08:33h | UTCThe year in cardiovascular medicine 2021: diabetes and metabolic disorders – European Heart Journal
Year in cardiovascular medicine: cardio-oncology 2020–21.
13 Jan, 2022 | 08:28h | UTCYear in cardiovascular medicine: cardio-oncology 2020–21 – European Heart Journal
The year in cardiovascular medicine 2021: heart failure and cardiomyopathies.
13 Jan, 2022 | 08:32h | UTC
The year in cardiovascular medicine 2021: dyslipidemia.
13 Jan, 2022 | 08:30h | UTCThe year in cardiovascular medicine 2021: dyslipidemia – European Heart Journal
The year in cardiovascular medicine 2021: digital health and innovation.
13 Jan, 2022 | 08:27h | UTCThe year in cardiovascular medicine 2021: digital health and innovation – European Heart Journal
ASCO Guideline Update: Adjuvant Therapy for Stage II Colon Cancer.
13 Jan, 2022 | 08:19h | UTCAdjuvant Therapy for Stage II Colon Cancer: ASCO Guideline Update – Journal of Clinical Oncology
M-A: Intermittent Fasting and Obesity-Related Health Outcomes.
13 Jan, 2022 | 08:22h | UTC
Systematic Review: Chemotherapy for the treatment of oral cavity and oropharyngeal cancer.
13 Jan, 2022 | 08:14h | UTCSummary: Chemotherapy for mouth and throat cancer – Cochrane Library
RCT: In full-term and near-term neonates, drug treatment of all clinically and electrographically detected seizures was not associated with reduced death rates or disability at 2 years compared with the treatment of only the clinically detected seizures.
13 Jan, 2022 | 08:24h | UTCCommentaries:
Should we treat electrographic seizures? – Neonatal Research
Subclinical Electrographic Seizures in the Newborn—Is More Treatment Better? – JAMA Network Open
Neonatal Seizures: Little Difference Between EEG/Clinical Treatment – Physician’s Weekly
Commentary on Twitter
NEST trial in @JAMANetworkOpen by @rodwhunt explores if treatment of EEG + clinical seizures compared with only treating clinical seizures in encephalopathic infants decreased odds of severe disability at 2 years of age. https://t.co/s3yYi6R3fV #EBNEOalerts #neoEBM #neotwitter pic.twitter.com/xoxVKC2a5z
— Evidence-Based Neo (@EBNEO) December 29, 2021