Daily Archives: December 15, 2021
M-A: Global percentage of asymptomatic SARS-CoV-2 infections around 40%.
15 Dec, 2021 | 08:47h | UTCCommentary: ~40 Percent With Confirmed COVID-19 Are Asymptomatic – HealthDay
Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.
15 Dec, 2021 | 08:43h | UTCNews release: COVID-19 infection, more likely than vaccines, to cause rare cardiovascular complications – University of Oxford
Commentaries on Twitter
Hugely important work from @JuliaHCox and colleagues:
In people <40, Pfizer carries a much lower risk of myocarditis than either Moderna **or SARS-CoV-2 infection** (annotations added)https://t.co/wqRts3ALqy pic.twitter.com/fnn1T39h1b
— David Juurlink (@DavidJuurlink) December 14, 2021
A case series published in @NatureMedicine shows an increased risk of myocarditis after receiving the Astra-Zeneca-Oxford, Pfizer-BioNTech and the Moderna COVID-19 vaccines, but SARS-CoV-2 infection carried a greater risk of myocarditis. https://t.co/6y7pZlJN70 pic.twitter.com/cBlKz9sUkg
— Nature Portfolio (@NaturePortfolio) December 14, 2021
Just published @NatureMedicine
The most comprehensive assessment of the rare events of myocarditis, pericarditis, arrhythmias after COVID and AZ, mRNA vaccineshttps://t.co/0bEdMJSLXg pic.twitter.com/eC5JOx0CmG— Eric Topol (@EricTopol) December 14, 2021
[Press release – not published yet] Pfizer’s Covid pill remains 89% effective for reducing the risk of hospitalization or death in final analysis.
15 Dec, 2021 | 08:46h | UTCCommentaries:
Pfizer’s Covid pill remains 89% effective in final analysis, company says – STAT
Pfizer confirms COVID pill’s results, potency versus omicron – Associated Press
Related:
8 lingering questions about the new Covid pills from Merck and Pfizer.
Commentary on Twitter (thread – click for more)
@pfizer releases more nirmatrelvir (#Paxlovid) data on #COVID19 final outcomes. Data are consistent, slightly better thant interim analysis. #IDTwitter
▪️ 88% overall hospitalization <=5days
▪️ No deaths in High Risk Trial (EPIC-HR)
▪️ Stopping drug 2.1%https://t.co/1D2LKan7tM— David Boulware, MD MPH (@boulware_dr) December 14, 2021
Rapidly spreading Omicron is now in 77 countries and WHO warns against assuming its effects are mild.
15 Dec, 2021 | 08:39h | UTC
Study suggests COVID-19 certificates may boost vaccine uptake in countries with below average coverage.
15 Dec, 2021 | 08:41h | UTCNews Release: COVID-19 certificates may boost vaccine uptake in countries with below average coverage – University of Oxford
Original Study: The effect of mandatory COVID-19 certificates on vaccine uptake: synthetic-control modelling of six countries – The Lancet Public Health
Commentary on Twitter
In our paper @TheLancetPH, @melindacmills and I found that mandatory vaccine passports are effective in increasing vaccine uptake! Already between announcement and introduction, France, Israel and Italy had strong uptick in vaccinations, esp young people: https://t.co/K0xnPdc4o1 https://t.co/WGvhpZjhyo pic.twitter.com/KGCNFmFgVD
— Tobias Rüttenauer (@ruettenauer) December 14, 2021
COVID-19 in 2022: controlling the pandemic is within our grasp.
15 Dec, 2021 | 08:36h | UTCCOVID-19 in 2022: controlling the pandemic is within our grasp – Nature Medicine
Commentaries on Twitter
What will the COVID-19 pandemic look like in 2022?
Who better to ask than @mvankerkhove, one of the busiest people in the world right now, who took the time to write this thoughtful World View for @NatureMedicine.https://t.co/jgodgPIDrK
— Ben Johnson ?? (@drbenjohnson) December 14, 2021
Vaccine inequity, inconsistent public health measures and new variants such as Omicron are prolonging the COVID-19 pandemic, but controlling the virus remains possible.
Worldview from @mvankerkhove @WHOhttps://t.co/vLmASqI8i7
— Nature Medicine (@NatureMedicine) December 14, 2021
Expert consensus and practical guidance: A global perspective on improving patient care in uncomplicated urinary tract infection.
15 Dec, 2021 | 08:33h | UTC
[Not published yet] Initial data from South Africa showed vaccine protection vs. Omicron infection may drop to 30% but does cut severe disease.
15 Dec, 2021 | 08:38h | UTCVaccine protection vs. omicron infection may drop to 30% but does cut severe disease – NPR
See also: South Africa Omicron study finds drop in vaccine protection, fewer hospitalized – CIDRAP
Position Paper: Diagnosis, management, and prevention of button battery ingestion in childhood.
15 Dec, 2021 | 08:32h | UTCVisual summary: Diagnosis, Management, and Prevention of Button Battery Ingestion in Childhood
Commentary on Twitter (thread – click for more)
Button battery ingestion in children⚠️: Important? guidelines for diagnosis and management from @ESPGHANSociety #GITwitter https://t.co/TQ1rfjQOpShttps://t.co/fxzzCEl2F2
— ESGE (@ESGE_news) December 14, 2021
Review: Diagnosis and management of acute appendicitis in adults.
15 Dec, 2021 | 08:28h | UTCDiagnosis and Management of Acute Appendicitis in Adults: A Review – JAMA (free for a limited period)
Author Interview: Current Management of Acute Appendicitis: Antibiotics or Surgical Intervention
Commentary: Antibiotics can be first-line therapy for uncomplicated appendicitis cases – Duke University Medical Center
M-A: Pharmacotherapy for adults with overweight and obesity – “phentermine–topiramate and GLP-1 receptor agonists proved the best drugs in reducing weight”.
15 Dec, 2021 | 08:30h | UTCPharmacotherapy for adults with overweight and obesity: a systematic review and network meta-analysis of randomised controlled trials – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
Pharmacotherapy for adults with overweight and #obesity – NEW systematic review and network meta-analysis of RCTs summarises the latest evidence for the benefits and harms of weight-lowering drugs. https://t.co/92fK1cKcww pic.twitter.com/INUe2plSQB
— The Lancet (@TheLancet) December 9, 2021
RCT: In preterm infants with respiratory distress syndrome, surfactant administration via a thin catheter did not improve outcomes.
15 Dec, 2021 | 08:26h | UTCEffect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome: The OPTIMIST-A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Minimally Invasive Surfactant Therapy to Prevent Bronchopulmonary Dysplasia in Extremely Preterm Infants – JAMA (free for a limited period)
Randomized crossover trial of metoprolol in patients with obstructive hypertrophic cardiomyopathy.
15 Dec, 2021 | 08:23h | UTCRandomized Trial of Metoprolol in Patients With Obstructive Hypertrophic Cardiomyopathy – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Early hospital discharge feasible following PCI for patients with STEMI.
15 Dec, 2021 | 08:24h | UTCEarly Hospital Discharge Following PCI for Patients With STEMI – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Infectious diseases learning pearls from inpatient ID consults.
15 Dec, 2021 | 08:22h | UTCID Learning Units from Inpatient ID Consults – HIV and ID Observations