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Daily Archives: December 8, 2021

[Preprint] Risk of Hospitalization, severe disease, and mortality due to COVID-19 in children with SARS-CoV-2 infection in Germany – “overall hospitalization rate associated with SARS-CoV-2 infection was 35.9 per 10,000 children, ICU admission rate was 1.7 per 10,000 and case fatality was 0.09 per 10,000”.

8 Dec, 2021 | 10:18h | UTC

Risk of Hospitalization, severe disease, and mortality due to COVID-19 and PIMS-TS in children with SARS-CoV-2 infection in Germany – medRxiv

Related:

Editorial: COVID-19 vaccines for children – “Although it is true that most children experience asymptomatic or mild disease, some will get quite sick, and a small number will die. It’s why children are vaccinated against influenza, meningitis, chickenpox, and hepatitis”.

Review: Should children under 12 years of age be vaccinated against COVID-19?

Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic year – “In total, 99.995% of children and young people with a positive SARS-CoV-2 test survived”.

 

WHO recommends against the use of convalescent plasma to treat COVID-19.

8 Dec, 2021 | 10:24h | UTC

News Release: WHO recommends against the use of convalescent plasma to treat COVID-19 – World Health Organization

See Guidance: WHO’s living guidelines on COVID-19 therapeutics

Infographic: A living WHO guideline on drugs for covid-19 – The BMJ

 

Commentary on Twitter (thread – click for more)

 

A first, small study suggests Omicron is a larger threat to Covid-19 immunity than other variants.

8 Dec, 2021 | 10:22h | UTC

A first, small study suggests Omicron is a larger threat to Covid-19 immunity than other variants – STAT

Original Study: SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection – medRxiv

 

Commentary from the author on Twitter (thread – click for more)

See also (thread – click for more)

 

RCT: In patients with severe Covid-19, high-flow oxygen therapy reduced the likelihood of invasive mechanical ventilation and decreased the time to clinical recovery compared to conventional oxygen therapy.

8 Dec, 2021 | 10:15h | UTC

Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19: A Randomized Clinical Trial – JAMA

Related:

Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research – “The two randomized controlled trials indicate superiority of non-invasive ventilation over high-flow nasal oxygen in reducing the need for intubation”.

[Preprint] RCT: non-invasive respiratory strategies in acute respiratory failure in patients with COVID-19 – CPAP reduced the composite outcome of intubation or death within 30 days; high-flow nasal oxygenation was not associated with better outcomes.

 

Phase 2 RCT: Immunogenicity and safety of a third dose of CoronaVac, and immune persistence of a two-dose schedule.

8 Dec, 2021 | 10:12h | UTC

Immunogenicity and safety of a third dose of CoronaVac, and immune persistence of a two-dose schedule, in healthy adults: interim results from two single-centre, double-blind, randomised, placebo-controlled phase 2 clinical trials – The Lancet Infectious Diseases

Invited Commentary: Booster doses for inactivated COVID-19 vaccines: if, when, and for whom – The Lancet Infectious Diseases

 

Video | COVID-19 Update: Omicron Variant.

8 Dec, 2021 | 10:09h | UTC

COVID-19 Update: Omicron Variant – JAMA

 

Beyond Omicron: what’s next for COVID’s viral evolution.

8 Dec, 2021 | 10:06h | UTC

Beyond Omicron: what’s next for COVID’s viral evolution – Nature

 

AAN Practice Advisory: Antiseizure medication withdrawal in patients who are seizure-free.

8 Dec, 2021 | 09:59h | UTC

Antiseizure Medication Withdrawal in Seizure-Free Patients: Practice Advisory Update Summary: Report of the AAN Guideline Subcommittee – Neurology

 

Prevention and management of hyperkalemia in patients treated with renin–angiotensin–aldosterone system inhibitors.

8 Dec, 2021 | 09:58h | UTC

Prevention and management of hyperkalemia in patients treated with renin–angiotensin–aldosterone system inhibitors – Canadian Medical Association Journal

 

Editorial: Omicron is bad, but the global response is worse – “The pandemic will not end while vaccine equity keeps getting pushed to the margins”.

8 Dec, 2021 | 10:07h | UTC

Omicron is bad but the global response is worse – Nature

 

ESC Position Paper: Optimal follow-up after acute pulmonary embolism.

8 Dec, 2021 | 10:02h | UTC

Optimal follow-up after acute pulmonary embolism: a position paper of the European Society of Cardiology Working Group on Pulmonary Circulation and Right Ventricular Function, in collaboration with the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology, endorsed by the European Respiratory Society – European Heart Journal

 

Commentary on Twitter

 

Bronchiolitis: evidence and guidance for practice.

8 Dec, 2021 | 09:55h | UTC

Bronchiolitis: evidence and guidance for practice – Evidently Cochrane

 

Review: Perioperative pain management issues unique to older adults undergoing surgery.

8 Dec, 2021 | 09:52h | UTC

Perioperative Pain Management Issues Unique to Older Adults Undergoing Surgery: A Narrative Review – Annals of Surgery Open

 

What Is of Recent Interest in Cardiac Imaging?: Insights From the JACC Family of Journals.

8 Dec, 2021 | 09:54h | UTC

What Is of Recent Interest in Cardiac Imaging?: Insights From the JACC Family of Journals – Journal of the American College of Cardiology

 

Raising awareness for time-limited trial discussion upon ICU triage and admission.

8 Dec, 2021 | 09:57h | UTC

Raising awareness for time-limited trial discussion upon ICU triage and admission – Intensive Care Medicine (if the link is paywalled, try this one)

 

Commentary on Twitter

 

M-A: Efficacy and safety associated with immune checkpoint inhibitors in unresectable hepatocellular carcinoma.

8 Dec, 2021 | 09:48h | UTC

Efficacy and Safety Associated With Immune Checkpoint Inhibitors in Unresectable Hepatocellular Carcinoma: A Meta-analysis – JAMA Network Open

 

Commentary on Twitter

 

Evaluation and management of pelvic organ prolapse.

8 Dec, 2021 | 09:50h | UTC

Evaluation and Management of Pelvic Organ Prolapse – Mayo Clinic Proceedings

 

ESMO Clinical Practice Guideline update on the use of immunotherapy in early stage and advanced renal cell carcinoma.

8 Dec, 2021 | 09:45h | UTC

ESMO Clinical Practice Guideline update on the use of immunotherapy in early stage and advanced renal cell carcinoma – Annals of Oncology

 

Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

8 Dec, 2021 | 09:47h | UTC

Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up – Annals of Oncology

 

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