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Daily Archives: October 10, 2021

Kids are losing school days to quarantines. Here’s a way to keep them in classrooms – “Test-to-stay could dramatically reduce close contact quarantines”.

10 Oct, 2021 | 21:52h | UTC

Kids are losing school days to quarantines. Here’s a way to keep them in classrooms – NPR

Related study: Cluster RCT: Daily contact testing of school-based contacts was non-inferior to self-isolation for control of COVID-19 transmission.

 


New Global Burden of Disease analyses show depression and anxiety among the top causes of health burden worldwide, and a significant increase due to the COVID-19 pandemic.

10 Oct, 2021 | 21:57h | UTC

News release: New Global Burden of Disease analyses show depression and anxiety among the top causes of health burden worldwide, and a significant increase due to the COVID-19 pandemic – Institute for Health Metrics and Evaluation

Original study: Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic – The Lancet

Commentaries:

Depression and anxiety disorders during the COVID-19 pandemic: knowns and unknowns – The Lancet

COVID-19 pandemic led to stark rise in depressive and anxiety disorders globally in 2020: study – The Lancet

Covid crisis dramatically worsened global mental health, study finds – The Guardian

 

Commentary on Twitter (thread – click for more)

 


RCT: Therapeutic-dose heparin superior to standard prophylactic or intermediate-dose heparins for thromboprophylaxis in high-risk hospitalized patients with COVID-19.

10 Oct, 2021 | 21:53h | UTC

Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19: The HEP-COVID Randomized Clinical Trial – JAMA Internal Medicine

Invited commentary: Anticoagulant Therapy in Patients Hospitalized With COVID-19 – JAMA Internal Medicine

Related studies (some conflicting results)

Another meta-analysis suggests standard-dose prophylactic anticoagulation is the best option for patients hospitalized with Covid-19.

M-A: Safety and efficacy of different prophylactic anticoagulation dosing regimens in critically and non-critically ill patients with COVID-19 – According to this analysis, standard-dose prophylactic anticoagulation should be the standard of care for hospitalized patients with COVID-19 who do not have an indication for therapeutic anticoagulation, irrespective of disease severity.

RCT: In noncritically ill patients hospitalized with Covid-19, therapeutic-dose anticoagulation with heparin increased the probability of survival to hospital discharge compared with usual-care thromboprophylaxis.

RCT: In critically ill patients with Covid-19, therapeutic anticoagulation with heparin did not result in improved outcomes compared to usual-care pharmacologic thromboprophylaxis.

RCT: In patients hospitalized with Covid-19 with elevated D-Dimer, a full-dose anticoagulation strategy based on rivaroxaban (full-dose heparins in unstable patients) + rivaroxaban to day 30 was not better than prophylactic anticoagulation and increased bleeding risk.

 

Commentary on Twitter

 


Heart-inflammation risk from Pfizer COVID vaccine is very low.

10 Oct, 2021 | 21:42h | UTC

Heart-inflammation risk from Pfizer COVID vaccine is very low – Nature

Original studies:

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

 


[Preprint] COVID-19 in children due to SARS-CoV-2 Delta strain resembles illness due to the Alpha variant, with short duration and similar symptom burden.

10 Oct, 2021 | 21:44h | UTC

Illness characteristics of COVID-19 in children infected with the SARS-CoV-2 Delta variant – medRxiv

 

Commentary on Twitter

 


Bioethics | The Trolley Problem and Vaccinating Young People Against COVID-19.

10 Oct, 2021 | 21:50h | UTC

The Trolley Problem and Vaccinating Young People Against COVID-19 – Science-Based Medicine

 


WHO report highlights global shortfall in investment in mental health.

10 Oct, 2021 | 21:39h | UTC

WHO report highlights global shortfall in investment in mental health – World Health Organization

Report: Mental Health ATLAS 2020 – World Health Organization

See also: World Mental Health Day 2021: Mental health care for all: let’s make it a reality – World Health Organization

 

Commentary on Twitter (thread – click for more)

 


World Mental Health Day: prioritize social justice, not only access to care.

10 Oct, 2021 | 21:37h | UTC

World Mental Health Day: prioritise social justice, not only access to care – The Lancet (free registration required)

 

Commentary on Twitter

 


M-A: Accuracy of the Patient Health Questionnaire-9 for screening to detect major depression.

10 Oct, 2021 | 21:34h | UTC

Accuracy of the Patient Health Questionnaire-9 for screening to detect major depression: updated systematic review and individual participant data meta-analysis – The BMJ

See calculator: PHQ-9 (Patient Health Questionnaire-9)

 

Commentary on Twitter

 


Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies.

10 Oct, 2021 | 21:31h | UTC

Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies – Molecular Psychiatry

Commentary: Age at onset of mental disorders: global meta-analysis provides data for targeting effective interventions – The Mental Elf

 


ACG Clinical Guidelines: Management of Benign Anorectal Disorders

10 Oct, 2021 | 21:29h | UTC

ACG Clinical Guidelines: Management of Benign Anorectal Disorders – The American Journal of Gastroenterology

 

Commentary on Twitter

 


Editorial: Brain health and its social determinants.

10 Oct, 2021 | 21:35h | UTC

Brain health and its social determinants – The Lancet

 

Commentary on Twitter

 


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