Daily Archives: October 8, 2021 | LinksMedicus Free Medical News & Perspectives

WHO Guidance: Antigen-detection in the diagnosis of SARS-CoV-2 infection.

8 Oct, 2021 | 10:47h | UTC

Antigen-detection in the diagnosis of SARS-CoV-2 infection – World Health Organization

Related infographics:

Use of antigen detection rapid diagnostic testing – World Health Organization

Diagnostic testing for SARS-CoV-2 infection – World Health Organization

Commentary on Twitter (thread – click for more)

Testing remains a critical component to the strategy to end the #COVID19 pandemic, and testing needs to be reliable, accessible, affordable, fast and linked to public health action.

So many around ? have worked hard to increase testing capacities @WHO https://t.co/VDPdU0VK4g

— Maria Van Kerkhove (@mvankerkhove) October 7, 2021

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

8 Oct, 2021 | 10:45h | UTC

A clinical case definition of post COVID-19 condition by a Delphi consensus, 6 October 2021 – World Health Organization

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

Commentary on Twitter (thread – click for more)

? WHO clinical case definition for post #COVID19 condition, also called 'long COVID' https://t.co/WoiLcwsgJX pic.twitter.com/Z0olrHlWPC

— World Health Organization (WHO) (@WHO) October 7, 2021

WHO Launches Strategy to Achieve Global Covid-19 Vaccination by mid-2022.

8 Oct, 2021 | 10:41h | UTC

Strategy to Achieve Global Covid-19 Vaccination by mid-2022 – World Health Organization

News release: WHO, UN set out steps to meet world COVID vaccination targets – World Health Organization

Commentaries:

WHO Believes 70% Vaccination Target is Possible – But Only if Wealthy Countries Make Way for COVAX and Africa – Health Policy Watch

WHO launches global COVID vaccination strategy – CIDRAP

Study shows an increased risk of Guillain-Barré Syndrome with the J&J vaccine; the estimated observed to expected rate ratio was 4.18 for the 42-day window.

8 Oct, 2021 | 10:40h | UTC

Association of Receipt of the Ad26.COV2.S COVID-19 Vaccine With Presumptive Guillain-Barré Syndrome, February-July 2021 – JAMA

Commentary on Twitter

Study suggests a potential small but statistically significant safety concern for #GuillainBarré syndrome following receipt of the @JanssenUS #COVID19 vaccine; findings considered preliminary pending analysis of medical records to establish a definitive Dx https://t.co/yZjJVkp6BA

— JAMA (@JAMA_current) October 7, 2021

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination.

8 Oct, 2021 | 10:29h | UTC

Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination, March−June 2021, England – Eurosurveillance

RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.

Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.

Heterologous Oxford–AstraZeneca and Moderna Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

Heterologous Oxford–AstraZeneca and BioNTech/Pfizer Vaccination induce increased levels of neutralizing antibody compared to 2 doses of Oxford–AstraZeneca.

[Preprint] Mixing Covid jabs has good immune response, study finds – “The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system”.

Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”.

Lab study shows heterologous AstraZeneca/Pfizer vaccination produces strong immune response against SARS-CoV-2 Delta variant.

Lab study shows a heterologous AstraZeneca + Pfizer immunization strategy provides stronger immunogenicity against Covid compared to homologous AZ + AZ or Pfizer + Pfizer strategies.

RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.

Commentary on Twitter

As more & more countries consider adding a 3rd #COVID19 vaccine dose into their national immunisation programmes, vaccine reactogenicity will become important, especially if 3rd dose is different to first 2 doses. We need more mix-n-match booster studies ?https://t.co/G57i9Ej7Nd

— Shamez Ladhani (@ShamezLadhani) October 7, 2021

Ivermectin: How false science created a Covid ‘miracle’ drug.

8 Oct, 2021 | 10:24h | UTC

Ivermectin: How false science created a Covid ‘miracle’ drug – BBC

Commentary on Twitter

Scientists evaluating ivermectin data for #COVID19
"had not found 'a single clinical trial' claiming to show that ivermectin prevented Covid deaths that did not contain 'either obvious signs of fabrication or errors so critical they invalidate the study'." https://t.co/Xndr6Q5LaS

— Isaac Bogoch (@BogochIsaac) October 7, 2021

How the risk of Covid-19 for kids compares to other dangers.

8 Oct, 2021 | 10:26h | UTC

How the risk of Covid-19 for kids compares to other dangers – Vox

Bioethics | People who want organ transplants must get the COVID-19 vaccine, a hospital says.

8 Oct, 2021 | 10:21h | UTC

People who want organ transplants must get the COVID-19 vaccine, a hospital say – NPR

Japanese evidence-based clinical practice guidelines for Liver Cirrhosis.

8 Oct, 2021 | 10:14h | UTC

Evidence-based clinical practice guidelines for Liver Cirrhosis 2020 – Journal of Gastroenterology

The German Guidelines for the treatment of anxiety disorders.

8 Oct, 2021 | 10:16h | UTC

The German Guidelines for the treatment of anxiety disorders: first revision – European Archives of Psychiatry and Clinical Neuroscience

Opinion | Covid-19 keeps delivering lessons about health care worker burnout. Will we learn them?

8 Oct, 2021 | 10:18h | UTC

Covid-19 keeps delivering lessons about health care worker burnout. Will we learn them? – STAT

Commentary on Twitter

Opinion: Delaying the important work of addressing burnout under the guise of "let's just get through this first" does a disservice to health care workers who need support and relief now. https://t.co/21s5NRvhdk

— STAT (@statnews) October 7, 2021

U.S. Data: Drug-resistant Infections led to $1.9 billion in health care costs, more than 10,000 deaths among older adults in one year.

8 Oct, 2021 | 10:11h | UTC

News release: Drug-resistant Infections Led to $1.9 Billion in Health Care Costs, More Than 10,000 Deaths Among Older Adults in One Year – Infectious Diseases Society of America

Original study: Mortality, Length of Stay, and Healthcare Costs Associated With Multidrug-Resistant Bacterial Infections Among Elderly Hospitalized Patients in the United States – Clinical Infectious Diseases

Commentaries:

Urgent, Comprehensive Federal Action Needed To Stem Mortality and Medicare Costs Associated With Antimicrobial Resistance – Clinical Infectious Diseases

Study highlights impact of antibiotic resistance on older Americans – CIDRAP

Position statement on percutaneous ablation of non-small cell lung cancer and metastatic disease to the lungs.

8 Oct, 2021 | 10:12h | UTC

Society of Interventional Radiology Multidisciplinary Position Statement on Percutaneous Ablation of Non-small Cell Lung Cancer and Metastatic Disease to the Lungs – Journal of Vascular and Interventional Radiology

Commentary: Society of Interventional Radiology issues guidance for minimally invasive lung cancer treatments – Health Imaging

Study suggests a 30-second interval between automated office blood pressure measurements is as accurate and reliable as a 60-second interval.

8 Oct, 2021 | 10:09h | UTC

Impact of 30- Versus 60-Second Time Intervals Between Automated Office Blood Pressure Measurements on Measured Blood Pressure – Hypertension (link to abstract – $ for full-text)

Commentary on Twitter

Guidelines recommend a 60-sec pause between automated office BP measures. This study indicates a 30-sec interval not only saves time but is just as accurate and reliable. @spjuraschek @therealaishak @TimAndersonMD @jenniferlcluett https://t.co/A77bvhatZq pic.twitter.com/wdrUqZDWs4

— Hypertension (@HyperAHA) October 7, 2021

State of the Art Review: Advances in acute myeloid leukemia.

8 Oct, 2021 | 10:05h | UTC

Advances in acute myeloid leukemia – The BMJ

Commentary on Twitter

Acute myeloid leukemia is an uncommon but potentially catastrophic diagnosis.

This review looks at new updates in our understanding of the biology of acute myeloid leukemia, its genetic and environmental risk factors, and new treatment options https://t.co/ugaCeYkqSH

— The BMJ (@bmj_latest) October 6, 2021

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines.

8 Oct, 2021 | 10:07h | UTC

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Cohort Study: Explanatory diagnoses following hospitalization for a brief resolved unexplained event.

8 Oct, 2021 | 10:03h | UTC

Explanatory Diagnoses Following Hospitalization for a Brief Resolved Unexplained Event – Pediatrics

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