Daily Archives: October 3, 2021
[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.
3 Oct, 2021 | 23:02h | UTCCommentaries:
Expert reaction to interim analysis of oral antiviral molnupiravir – Science Media Centre
Covid antiviral pill can halve risk of hospitalization – BBC
Why Merck’s Covid-19 pill molnupiravir could be so important – Vox
Commentaries on Twitter
.@DrEricDing convinced many that stopping the #molnupiravir trial early for benefit was a good idea
But it was NOT
Large body of evidence suggests that stopping early for benefit biases the results: overestimates the benefits of the treatment #EBM https://t.co/b3tHEtliO0 https://t.co/LwuCgqcY0C pic.twitter.com/vyPWc0nd37
— Kari Tikkinen (@KariTikkinen) October 2, 2021
(thread – click for more)
?BREAKING—New oral anti-viral drug *molnupiravir* cuts risk of #COVID19 hospitalization and death **in HALF** in a randomized trial. Results so astounding that the trial is being stopped early, and Merck plans to apply for emergency authorization ASAP. ? https://t.co/g8JGNzvuRg pic.twitter.com/K1SwC3QFXS
— Eric Feigl-Ding (@DrEricDing) October 1, 2021
Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance.
3 Oct, 2021 | 22:59h | UTCVaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance – The BMJ
Original Guidance: NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.
Related:
Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.
Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.
Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)
[Preprint] Assessing the Burden of COVID-19 in Developing Countries: Systematic Review, Meta-Analysis, and Public Policy Implications.
3 Oct, 2021 | 22:56h | UTC
Commentary on Twitter
Our big new study on the infection fatality rate of COVID-19 in developing countries is out
The news is pretty grim ?https://t.co/woX4ijWOQy
— Health Nerd (@GidMK) October 2, 2021
Will the pandemic fade into an ordinary disease like the flu? The world is watching Denmark for clues.
3 Oct, 2021 | 22:58h | UTC
New analysis shows benefits of offering two doses of COVID-19 vaccine to children aged 12-17 clearly outweigh risks.
3 Oct, 2021 | 22:52h | UTCOriginal report: Vaccinating adolescents against SARS-CoV-2 in England: a risk-benefit analysis
Related: Covid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors.
Editorial | Clinical ethics: consent for vaccination in children.
3 Oct, 2021 | 22:53h | UTCClinical ethics: consent for vaccination in children – Archives of Disease in Childhood
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.
3 Oct, 2021 | 22:41h | UTC
Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.
3 Oct, 2021 | 22:49h | UTCCovid-19 vaccination: evidence of waning immunity is overstated – The BMJ
Related:
COVID vaccine effects wane over time but still prevent death and severe illness.
Perspective | What we actually know about waning immunity.
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Studies: COVID vaccine protection waning against infection but not hospitalization.
Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.
WHO prioritizes access to diabetes and cancer treatments in new Essential Medicines Lists.
3 Oct, 2021 | 22:46h | UTCNews Release: WHO prioritizes access to diabetes and cancer treatments in new Essential Medicines Lists – World Health Organization
Report: WHO model list of essential medicines – 22nd list, 2021 – World Health Organization
Commentary: For the first time, WHO committee recommends action on high-priced essential medicines – STAT
Commentary on Twitter (thread – click for more)
? WHO 2021 Essential Medicines Lists have 20 new medicines for adults & 17 for children, incl. insulin analogues, new oral medicines for diabetes & medicines for cancer treatment https://t.co/LfWwHEZtuM pic.twitter.com/HMFOP8ioBf
— World Health Organization (WHO) (@WHO) October 1, 2021
Systematic Review: Is exercise an effective therapy to treat long-lasting low back pain?
3 Oct, 2021 | 22:32h | UTCSummary: Is exercise an effective therapy to treat long-lasting low back pain? – Cochrane Library
Original Study: Exercise therapy for chronic low back pain – Cochrane Library
Commentary on Twitter
New @CochraneBack Cochrane review – 249 RCTs – ~25,000 participants – consistent, moderately strong evidence that #exercise treatment was more effective than no treatment or usual care for the management of chronic #backpain ? #systematicreview: https://t.co/X10rUtnNNb pic.twitter.com/O0AtZK2gZq
— Cochrane UK (@CochraneUK) October 2, 2021
Intensive care triage under exceptional resource scarcity.
3 Oct, 2021 | 22:48h | UTCIntensive care triage under exceptional resource scarcity – Swiss Medical Weekly
ADA Consensus Report: The Management of Type 1 Diabetes in Adults.
3 Oct, 2021 | 22:38h | UTCRelated: Guideline: ADA 2021 Standards of Medical Care in Diabetes
Commentary on Twitter
What a fantastic symposium on the management of #T1D at #EASD2021! Read the full ADA–EASD consensus report here https://t.co/8cEm8N0Enr pic.twitter.com/uMj2R64CkK
— Diabetologia (@DiabetologiaJnl) October 1, 2021
Physician Well-being 2.0: Where Are We and Where Are We Going?
3 Oct, 2021 | 22:36h | UTCPhysician Well-being 2.0: Where Are We and Where Are We Going? – Mayo Clinic Proceedings
Related:
[Abstract Only] Assessment of Risk Factors for Suicide Among US Health Care Professionals
Beyond Burnout: Docs Decry ‘Moral Injury’ From Financial Pressures of Health Care
Perspective: Hospital Administration Response to Physician Stress and Burnout
Opinion: It’s Time to Talk About Physician Burnout and Moral Injury
Systematic Review: Effect of Organization-Directed Workplace Interventions on Physician Burnout
Perspective: The 3 Causes Of Physician Burnout (And Why There’s No Simple Solution)
Physician Burnout: A Global Crisis (several resources on the subject)
Systematic Review: Does testing for cancer in people with unprovoked blood clots in the legs and lungs reduce cancer- and blood clot-related death and illness?
3 Oct, 2021 | 22:33h | UTCOriginal article: Effect of testing for cancer on cancer‐ or venous thromboembolism (VTE)‐related mortality and morbidity in people with unprovoked VTE – Cochrane Library
RCT: Early computed tomography coronary angiography in patients with suspected acute coronary syndrome did not improve one year clinical outcomes.
3 Oct, 2021 | 22:35h | UTC
Commentary on Twitter
In this RCT, early CT coronary angiography in the emergency department for patients with suspected / provisional diagnosis of acute coronary syndrome had no effect on rate of death or subsequent non-fatal #heartattack at 1 year.@bmj_latest #Wondrmedicalhttps://t.co/usNKEGPDa4
— Prof Chris P Gale (@cpgale3) October 1, 2021
Coronary microvascular dysfunction: Considerations for diagnosis and treatment.
3 Oct, 2021 | 22:29h | UTCRelated:
Cohort study: Clinical characteristics and prognosis of patients with microvascular angina.
Position Paper on ‘Coronary Microvascular Dysfunction in Cardiovascular Disease’
Guide to Statistics and Methods: Interim Analyses During Group Sequential Clinical Trials.
3 Oct, 2021 | 22:30h | UTCInterim Analyses During Group Sequential Clinical Trials – JAMA (free for a limited period)
A new surgical robot is smaller, nimbler, and cheaper, its maker claims. But will it be better for patients?
3 Oct, 2021 | 22:26h | UTC
Oral health care for the critically ill: a narrative review.
3 Oct, 2021 | 22:25h | UTCOral health care for the critically ill: a narrative review – Critical Care
Ketogenic diets in the management of type 1 diabetes: Safe or safety concern?
3 Oct, 2021 | 22:28h | UTC
Review | Chronic hypertension and superimposed preeclampsia: screening and diagnosis.
3 Oct, 2021 | 22:23h | UTC