Daily Archives: September 9, 2021
[Preprint] Ineffective neutralization of the SARS-CoV-2 Mu variant by convalescent and vaccine sera.
9 Sep, 2021 | 10:02h | UTCIneffective neutralization of the SARS-CoV-2 Mu variant by convalescent and vaccine sera – bioRxiv
Related: United States boosts tracking of coronavirus strains as Mu variant draws scrutiny – Science
Commentary on Twitter (thread – click for more)
?Bad news on #MuVariant—Japanese scientists: "Mu variant is highly resistant to sera from convalescent & [Pfizer]-vaccinated people. Direct comparison of different spike proteins revealed that Mu spike is more resistant…than all other current variants”?https://t.co/Ilf5gh3OGd pic.twitter.com/DbdJVGZTjz
— Eric Feigl-Ding (@DrEricDing) September 8, 2021
Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.
9 Sep, 2021 | 10:04h | UTCStudy 1: Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy – JAMA
Study 2: Receipt of mRNA Covid-19 Vaccines and Risk of Spontaneous Abortion – New England Journal of Medicine
Commentary on Twitter
? NO LINK BETWEEN MISCARRIAGE & COVID VACCINATION
This @JAMA_current study examined 105446 pregnancies, including 13160 miscarriages
Women with pregnancies ending in miscarriage were NOT more likely to have had ? in prior 28 days than those that didnthttps://t.co/7cFELq1oPM
— Ilan Schwartz MD PhD (@GermHunterMD) September 8, 2021
[Preprint] RCT: Additional heterologous vs. homologous booster vaccination in immunosuppressed patients without SARS-CoV-2 antibody seroconversion after primary mRNA vaccination.
9 Sep, 2021 | 09:55h | UTC
Commentary on Twitter (thread – click for more)
Results of 60-person randomized trial of 3rd shot of mRNA or AZ vax in people on rituximab who didn't seroconvert after BNT-Pfizer (most) or Moderna vax. Found dose 3 reduced those with no humoral or cellular response from 31% to 6% …1/2 https://t.co/HIjeDaFy7w Preprint #IC
— Hilda Bastian, PhD (@hildabast) September 8, 2021
AstraZeneca bosses warn against rush for boosters – “giving the most vulnerable, who may not have built up a full immune response from the first two, a third, top-up dose is “sensible”. But any decision to give a third, booster jab “to large swathes of the population”, to extend their protection from the first two, must be based on clinical data”.
9 Sep, 2021 | 09:59h | UTCAstraZeneca bosses warn against rush for boosters – BBC
Commentary on Twitter (thread – click for more)
"Moving too quickly to boost across the entire adult population will deprive us of these insights, leaving this important decision to rest on limited data," Mr Soriot and Sir Mene write.https://t.co/xTAk7yyu5G
— The Sharing Scientist (@ScienceShared) September 8, 2021
WHO appeals for countries to postpone COVID-19 vaccine boosters until 2022 to prioritize vaccinating the most at-risk people around the world who are yet to receive their first dose.
9 Sep, 2021 | 10:00h | UTCSee also:
WHO chief urges halt to booster shots for rest of the year – Associated Press
WHO extends moratorium on booster COVID vaccine doses – CIDRAP
Perspective | The plan to stop every respiratory virus at once – “The benefits of ventilation reach far beyond the coronavirus. What if we stop taking colds and flus for granted, too?”
9 Sep, 2021 | 09:54h | UTCThe Plan to Stop Every Respiratory Virus at Once – The Atlantic
Related:
Recommendations for ventilation of indoor spaces to reduce COVID-19 transmission.
We studied how to reduce airborne COVID spread in hospitals. Here’s what we learnt.
WHO: Roadmap to improve and ensure good indoor ventilation in the context of COVID-19
CDC releases new ventilation guidelines for indoor environments to reduce Covid-19 risk
Balancing incentives and disincentives for vaccination in a pandemic.
9 Sep, 2021 | 09:52h | UTCBalancing incentives and disincentives for vaccination in a pandemic – Nature Medicine
A large observational study suggests eating a plant-rich diet could reduce the risk of developing severe COVID-19.
9 Sep, 2021 | 09:51h | UTCEating a plant rich diet reduces risk of developing COVID-19 – King’s College London
Original study: Diet quality and risk and severity of COVID-19: a prospective cohort study – Gut
Emoji are proposed as a powerful way for patients and doctors to communicate.
9 Sep, 2021 | 09:06h | UTCOriginal article: Emoji for the Medical Community—Challenges and Opportunities – JAMA (free for a limited period)
Commentary on Twitter (thread – click for more)
1/ Our @JAMA_current paper is out today describing the need for Emojis in Medicine.
A thread.
It might seem silly at first, but here’s why it's important. At the core of what we do as doctors is listen to patients, so we can care and treat for them. https://t.co/I1zEBsPcWv— Shuhan He (@ShuhanHeMD) September 7, 2021
The Lancet Series: Out-of-hospital cardiac arrest 2021.
9 Sep, 2021 | 09:07h | UTCHomepage: Out-of-hospital cardiac arrest 2021 (free registration required for both articles)
Cardiopulmonary resuscitation in special circumstances
Brain injury after cardiac arrest
Commentary on Twitter (thread – click for more)
Early recognition and response to cardiac arrest are crucial.
This Series of two papers extends previous reviews published in The Lancet. Out-of-hospital cardiac arrest 2021: https://t.co/AdZsriZFxx pic.twitter.com/mlwyCzayPn
— The Lancet (@TheLancet) September 8, 2021
RCT: A Seven-days course of antibiotics for the treatment of bloodstream infections by Enterobacterales was noninferior to a 14-days course.
9 Sep, 2021 | 09:03h | UTC
Commentary on Twitter
SHORTEN RCT ???@CMIJournal
Seven versus 14-days course of antibiotics for the treatment of bloodstream infections by Enterobacterales
7-day course of antibiotics as the preferential treatment for eBSI, as long as the source is properly controlled https://t.co/pyaOMl52us pic.twitter.com/wK1sgeMe36— Antibiotic Steward ??? Bassam Ghanem (@ABsteward) September 8, 2021
Editorial | Anticholinergic drugs and dementia: time for transparency in the face of uncertainty.
9 Sep, 2021 | 08:57h | UTCSystematic review: Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome – Cochrane Library
Commentary on Twitter
Anticholinergic drugs may double the risk of developing dementia. What should we be doing right now?
Editorial with @JenMStevenson for @CochraneLibrary published todayhttps://t.co/808wSGPUtm— Henry Woodford (@woodford_henry) September 8, 2021
RCT: No benefit from Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis.
9 Sep, 2021 | 08:59h | UTCCyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Review: Management of severe traumatic brain injury in regions with limited resources.
9 Sep, 2021 | 08:56h | UTCManagement of severe traumatic brain injury in regions with limited resources – Brain Injury
Perspective | Rethinking medication adherence.
9 Sep, 2021 | 08:55h | UTCRethinking Medication Adherence – Therapeutics Initiative
Review: Heart failure with mid-range or mildly reduced ejection fraction.
9 Sep, 2021 | 08:52h | UTCHeart failure with mid-range or mildly reduced ejection fraction – Nature Reviews Cardiology (free for a limited period)
Commentary on Twitter
In a new Review, Lars Lund et al. discuss the epidemiology, clinical profile, prognosis and potential treatment of patients with #HeartFailure with mid-range or mildly reduced ejection fraction (HFmrEF) https://t.co/npDGByESCj pic.twitter.com/dWcRZLJGHW
— Nature Reviews Cardiology (@NatRevCardiol) September 8, 2021
Radiation‐induced cardiovascular disease: review of an underrecognized pathology.
9 Sep, 2021 | 08:54h | UTC
Pancreatic Cancer: A Review.
9 Sep, 2021 | 08:51h | UTCPancreatic Cancer: A Review – JAMA (free for a limited period)