Daily Archives: September 7, 2021
Spread of Delta SARS-CoV-2 variant driven by a combination of immune escape and increased infectivity.
7 Sep, 2021 | 21:49h | UTCOriginal article: SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion – Nature
Cochrane review: evidence is insufficient to draw meaningful conclusions if SARS‐CoV‐2-specific monoclonal antibodies are effective in the treatment of COVID-19.
7 Sep, 2021 | 21:51h | UTCOriginal review: SARS‐CoV‐2‐neutralising monoclonal antibodies for treatment of COVID‐19 – Cochrane Library
Chile authorizes Sinovac vaccine for kids of 6 and older.
7 Sep, 2021 | 21:45h | UTCChile authorizes Sinovac vaccine for kids of 6 and older – Associated Press
Kids and COVID: why young immune systems are still on top.
7 Sep, 2021 | 21:46h | UTCKids and COVID: why young immune systems are still on top – Nature
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
7 Sep, 2021 | 21:48h | UTCEffectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy – Nature Medicine
Commentaries on Twitter
NEW: Estimated vaccine effectiveness in #pregnancy from 7 through to 56 d after second dose was 96% (95% CI; 89–100%) for any documented infection, 97% (91–100%) for infections with documented symptoms & 89% (43–100%) for #COVID19-related hospitalization. https://t.co/bm950wUWGL
— All Source Pregnancy (@PregnancyAll) September 7, 2021
The Pfizer-BioNTech mRNA COVID-19 vaccine was estimated to have high vaccine effectiveness in pregnant women, which is similar to the effectiveness estimated in the general population, according to a @NatureMedicine paper. https://t.co/oz5zn7zNdq pic.twitter.com/9IP5ocxzXs
— Nature Portfolio (@NaturePortfolio) September 7, 2021
Recent cannabis use linked to increased risk of myocardial infarction in young adults: a cross-sectional study.
7 Sep, 2021 | 21:38h | UTCNews release: Recent cannabis use linked to heart attack risk in younger adults – Canadian Medical Association Journal
Commentary: Young adult cannabis consumers nearly twice as likely to suffer from a heart attack, research shows – CNN
[Preprint] M-A of 12.011.447 individuals finds individuals previously infected with SARS-CoV-2 had an 81% reduction in odds of a reinfection.
7 Sep, 2021 | 21:42h | UTC
Commentary on Twitter
A new systematic review of over 12 million people from 54 studies at up to 8 months following Covid. >90% prevalence of IgG antibodies, reinfection 0.2% (an 81% risk reduction) https://t.co/ljir4DV1zU ("did not examine evidence for immunity against the new variants") pic.twitter.com/pT7A2KA9FV
— Eric Topol (@EricTopol) September 7, 2021
AAP flu recommendations allow for coadministration with COVID-19 vaccine.
7 Sep, 2021 | 21:44h | UTCNews release: AAP flu recommendations allow for coadministration with COVID-19 vaccine – American Academy of Pediatrics
Technical report: Recommendations for Prevention and Control of Influenza in Children, 2021–2022 – American Academy of Pediatrics
Commentary on Twitter
The 2021-’22 @AmerAcadPeds flu policy emphasizes the importance of flu vaccination during the SARS-CoV-2 pandemic, allows for coadministration with COVID-19 vaccine. https://t.co/usLaO276Ku pic.twitter.com/EaL5vocxMm
— AAP News (@AAPNews) September 7, 2021
Supplement: Current Issues in Venous Thromboembolism.
7 Sep, 2021 | 21:36h | UTCHomepage: Current Issues in Venous Thromboembolism – Postgraduate Medicine
Editorial: Current issues in venous thromboembolism
A review of upper extremity deep vein thrombosis
Outpatient treatment of emergency department patients diagnosed with venous thromboembolism
Venous thromboembolism prophylaxis in high-risk orthopedic and cancer surgery
Prophylaxis and treatment of COVID-19 related venous thromboembolism
Challenges in the diagnostic approach of suspected pulmonary embolism in COVID-19 patients
Post-hospital discharge venous thromboembolism prophylaxis in medically ill patients
Radiologic mimics of pulmonary embolism
A comprehensive review of DOACs for cancer associated VTE prophylaxis or treatment
The Lancet Series: Interstitial Lung Disease 2021.
7 Sep, 2021 | 21:37h | UTCHomepage: Interstitial Lung Disease 2021 (free registration required for all articles)
Early diagnosis of fibrotic interstitial lung disease: challenges and opportunities
Treatment of fibrotic interstitial lung disease: current approaches and future directions
Interstitial lung diseases: quo vadis?
Moving beyond usual interstitial pneumonia to define progressive fibrotic interstitial lung disease
Commentary on Twitter (thread – click for more)
? The term interstitial lung disease (ILD) refers to a diverse group of inflammatory & fibrotic conditions—with fibrotic ILD being a disease subset that constitutes a major global health problem.
Read the new @TheLancet & @LancetRespirMed Series. https://t.co/zV2Vw2l4rV pic.twitter.com/AqAe4GUlmr
— The Lancet (@TheLancet) September 7, 2021
Isn’t it time to abandon ARDS? The COVID-19 lesson.
7 Sep, 2021 | 21:34h | UTCIsn’t it time to abandon ARDS? The COVID-19 lesson – Critical Care
Commentary on Twitter
#CritCare #OA #Gattinoni & #Marini: Keeping or abandoning #ARDS?
▶️ pros
▶️ conshttps://t.co/tIhusXT2S7#FOAMed #FOAMcc #BMC #COVID19 #Rx #RCT #PEEP #respiratory_failure #Personalized pic.twitter.com/M6aoiSAn3m— Critical Care (@Crit_Care) September 7, 2021
Extended intervals and extra doses of the AstraZeneca vaccine are associated with increased immunogenicity.
7 Sep, 2021 | 10:56h | UTCInvited commentary: Longer intervals and extra doses of ChAdOx1 nCoV-19 vaccine
Commentaries on Twitter
(thread – click for more)
Substudy suggests extended interval (up to 45 wks) before 2nd dose of ChAdOx1 nCoV-19 leads to increased antibody titres, offering more flexibility in vaccine schedules.
Extended interval before 3rd dose resulted in further increase in immune responses. https://t.co/J3xOwSSYMN pic.twitter.com/8GotDI4ctS
— The Lancet (@TheLancet) September 2, 2021
(thread – click for more)
New @TheLancet
The heightened immune response to longer spacing @AstraZeneca 1st -> 2nd vaccine doses and the response 3rd booster dose, with high neutralizing antibodies and T cellshttps://t.co/A2UcPVIFYP pic.twitter.com/zfYaW0T8Yf— Eric Topol (@EricTopol) September 1, 2021
Opinion | Liquid biopsy: misplaced faith in early cancer detection?
7 Sep, 2021 | 21:30h | UTCLiquid biopsy: misplaced faith in early cancer detection? – STAT
Commentary on Twitter
Opinion: "The real money isn’t in testing the relatively few people with advanced cancer, it’s in testing everyone else: those not known to have cancer." Screening liquid biopsies could become standard care before we know if they save lives https://t.co/1IAo5Kb0vm via @statnews
— Gideon Gil (@GideonGil) August 31, 2021
Defining pediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement.
7 Sep, 2021 | 21:26h | UTCDefining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement – The Lancet Gastroenterology & Hepatology (free registration required)
Commentary on Twitter
New Viewpoint – Eslam et al – Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statementhttps://t.co/YIW0DL7u5O#NAFLD #MAFLD #fattyliver #LiverTwitter @eslamm1222 pic.twitter.com/2AIHksqIgj
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) August 6, 2021
Antibiotics use is linked to increased risk of subsequent colorectal cancer.
7 Sep, 2021 | 21:25h | UTCCommentaries:
Antibiotics linked to increased risk of colon cancer – Umea University
Study links antibiotics use and increased subsequent risk of colorectal cancer – MedicalResearch.com
[Preprint] Large cohort study in Brazil showed AstraZeneca vaccine had high overall effectiveness against severe disease to individuals up to 89 years of age. In comparison, CoronaVac had high overall effectiveness against severe disease in individuals up to 79 years.
7 Sep, 2021 | 10:54h | UTC
Annual Update in Intensive Care and Emergency Medicine 2021 – Covid articles.
7 Sep, 2021 | 10:50h | UTCSecondary infections in critically ill patients with COVID-19
Tracheostomy for COVID-19: evolving best practice
See also: Non-Covid articles
Case series: COVID-19 mRNA vaccination leading to CNS inflammation.
7 Sep, 2021 | 10:49h | UTCCOVID-19 mRNA vaccination leading to CNS inflammation: a case series – Journal of Neurology
Opinion | Video: Immunity is the only way through a pandemic (w/Dr. Monica Gandhi).
7 Sep, 2021 | 10:45h | UTCImmunity Is The Only Way Through A Pandemic (w/Dr. Monica Gandhi) – ZDoggMD
CDC report: Hospitalization rates for Covid-19 were 10 times higher among unvaccinated than among fully vaccinated adolescents.
7 Sep, 2021 | 10:52h | UTCCommentaries:
More kids hospitalized with Covid-19 in states with lower vaccination rates, CDC report finds – CNN
Child COVID hospital cases up in low-vaccination states – CIDRAP
Commentary on Twitter
From late June to mid-August, there was a 10x increase in the rate of hospitalizations among children ages 0-4 with #COVID19 while the #DeltaVariant was widely circulating. It is critical for children to #maskup and get vaccinated if eligible. Learn more: https://t.co/aHC1vYdKVG. pic.twitter.com/uUeNPG6d5r
— CDC (@CDCgov) September 3, 2021
[Not published yet] Sinovac booster shot reverses drop in antibody activities against Delta-study.
7 Sep, 2021 | 10:47h | UTCSinovac booster shot reverses drop in antibody activities against Delta-study – Reuters
Commentary on Twitter
A booster dose of Sinovac Biotech's COVID-19 vaccine reversed a decline in antibody activities against the Delta variant, a study showed, easing some concerns about its longer-term immune response to the highly contagious strain of the virus. https://t.co/QdmMYVBrvl
— Reuters Health (@Reuters_Health) September 6, 2021
Medical, ethical, and legal aspects of end-of-life dilemmas in the intensive care unit.
7 Sep, 2021 | 10:37h | UTC
Cohort study: Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest.
7 Sep, 2021 | 10:41h | UTC
Commentary on Twitter
Established/novel blood brain injury markers early predict good neuro-outcome/absence of pathological prognostic findings post CA
?NSE/S100B may prevent premature WLST
?NFL highest predictive capacity
Here visual abstract, full results #FOAMcc @yourICM https://t.co/3klcew33bD pic.twitter.com/1agsFCw6RF— Intens Care Med (@yourICM) September 4, 2021
Tube feeding for people with severe dementia: making decisions.
7 Sep, 2021 | 10:39h | UTCTube feeding for people with severe dementia: making decisions – Evidently Cochrane
Annual Update in Intensive Care and Emergency Medicine 2021 – Non-Covid articles.
7 Sep, 2021 | 10:43h | UTCAdvanced management of intermediate-high risk pulmonary embolism
Pathophysiology and clinical implications of the veno-arterial PCO2 gap
To prone or not to prone ARDS patients on ECMO
Management of acute metabolic acidosis in the ICU: sodium bicarbonate and renal replacement therapy
Acute kidney injury in ECMO patients
Still a place for aortic counterpulsation in cardiac surgery and patients with cardiogenic shock?
See also: Covid articles